Channel:  Harvard Program in Therapeutic Sciences

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

114 Articles

Inferring reaction network structure from single-cell, multiplex data, using toric systems theory
Wang, S., Lin, J.-r., Sontag, E. D., Sorger, P. K.
10.1101/731018 — Posted: 2019-08-09
Rapid heuristic inference of antibiotic resistance and susceptibility by genomic neighbor typing
Brinda, K., Callendrello, A., Ma, K. C., MacFadden, D. R., Charalampous, T., Lee, R. S., Cowley, L., Wadsworth, C. B., Grad, Y. H., Kucherov, G., O'Grady, J., Baym, M., Hanage, W. P.
10.1101/403204 — Posted: 2019-08-07
Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma
Jerby, L., Neftel, C., Shore, M. E., McBride, M. J., Haas, B., Izar, B., Weissman, H. R., Volorio, A., Boulay, G., Cironi, L., Richman, A. R., Broye, L. C., Gurski, J. M., Luo, C. C., Mylvaganam, R., Nguyen, L., Mei, S., Melms, J. c., Georgescu, C., Cohen, O., Buendia-Buendia, J. E., Cuoco, M. S., Labes, D., Zollinger, D. R., Beechem, J. M., Nielsen, P., Chebib, I., Cote, G., Choy, E., Letovanec, I., Cherix, S., Wagle, N., Sorger, P. K., Haynes, A. B., Mullen, J. T., Stamenkovic, I., Rivera, M. N., Kadoch, C., Rozenblatt-Rosen, O., Suva, M. L., Riggi, N., Regev, A.
10.1101/724302 — Posted: 2019-08-04
Facetto: Combining Unsupervised and Supervised Learning for Hierarchical Phenotype Analysis in Multi-Channel Image Data
Krueger, R., Beyer, J., Jang, W.-D., Kim, N. W., Sokolov, A., Sorger, P. K., Pfister, H.
10.1101/722918 — Posted: 2019-08-02
Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer
Rashid, R., Gaglia, G., Chen, Y.-A., Lin, J.-R., Du, Z., Maliga, Z., Schapiro, D., Yapp, C., Muhlich, J., Sokolov, A., Sorger, P., Santagata, S.
10.1101/704114 — Posted: 2019-07-17
Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
Chopra, S. S., Jenney, A., Palmer, A., Niepel, M., Chung, M., Mills, C., Sivakumaren, S. C., Liu, Q., Chen, J.-Y., Yapp, C., Asara, J., Gray, N. S., Sorger, P. K.
10.1101/700625 — Posted: 2019-07-12
A curative combination therapy for lymphomas achieves high fractional cell killing through low cross-resistance and drug additivity but not synergy
Palmer, A. C., Chidley, C., Sorger, P. K.
10.1101/462184 — Posted: 2019-07-12
Crosstalk and Ultrasensitivity in Protein Degradation Pathways
Mallela, A., Nariya, M. K., Deeds, E. J.
10.1101/594085 — Posted: 2019-03-30
Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity
Hafner, M., Mills, C. E., Subramanian, K., Chen, C., Chung, M., Boswell, S. A., Everley, R. A., Liu, C., Walmsley, C. S., Juric, D., Sorger, P.
10.1101/211680 — Posted: 2019-03-19
Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming
Wang, H., Sheehan, R. P., Palmer, A. C., Everley, R. A., Boswell, S. A., Ron-Harel, N., Ringel, A. E., Holton, K. M., Jacobson, C. A., Erickson, A. R., Maliszewski, L., Haigis, M. C., Sorger, P. K.
10.1101/365841 — Posted: 2019-03-12

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