Channel:  Harvard Program in Therapeutic Sciences

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

103 Articles

Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
Mills, C. E., Subramanian, K., Hafner, M., Niepel, M., Gerosa, L., Chung, M., Victor, C., Gaudio, B., Yapp, C., Nirmal, A. J., Clark, N., Sorger, P. K.
10.1101/2021.08.27.457854 — Posted: 2022-07-08
Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma
Coy, S., Wang, S., Stopka, S. A., Lin, J.-R., Rashid, R., Yapp, C., Ritch, C. C., Khadka, P., Regan, M., Hwang, J., Wen, P. Y., Bandopadhayay, P., Ligon, K. L., Agar, N. Y., Sorger, P. K., Touat, M., Santagata, S.
10.1101/2022.01.12.475925 — Posted: 2022-01-12
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Froehlich, F., Gerosa, L., Muhlich, J. L., Sorger, P. K.
10.1101/2022.02.17.480899 — Posted: 2022-02-18
Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data
Warchol, S., Krueger, R., Nirmal, A. J., Gaglia, G., Jessup, J., Ritch, C. C., Hoffer, J., Muhlich, J. L., Burger, M., Jacks, T. L., Santagata, S., Sorger, P. K., Pfister, H.
10.1101/2022.05.09.490039 — Posted: 2022-08-11
Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks
Lakrisenko, P., Stapor, P., Grein, S., Paszkowski, Łukasz, Pathirana, D., Fröhlich, F., Lines, G. T., Weindl, D., Hasenauer, J.
10.1101/2022.08.08.503176 — Posted: 2022-08-11
KINOMO: A non-negative matrix factorization framework for recovering intra- and inter-tumoral heterogeneity from single-cell RNA-seq data
Tagore, S., Wang, Y., Biermann, J., Rabadan, R., Azizi, E., Izar, B.
10.1101/2022.05.02.490362 — Posted: 2022-05-04
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Chidley, C., Darnell, A. M., Gaudio, B. L., Lien, E. C., Barbeau, A. M., Vander Heiden, M. G., Sorger, P. K.
10.1101/2023.01.26.525375 — Posted: 2023-01-26
Cell Spotter (CSPOT): A machine-learning approach to automated cell spotting and quantification of highly multiplexed tissue images
Nirmal, A. J., Yapp, C., Santagata, S., Sorger, P.
10.1101/2023.11.15.567196 — Posted: 2023-11-17
Multiplexed 3D Analysis of Immune States and Niches in Human Tissue
Yapp, C., Nirmal, A. J., Zhou, F. Y., Maliga, Z., Tefft, J., Montero Llopis, P., Murphy, G. F., Lian, C., Danuser, G., Santagata, S., Sorger, P. K.
10.1101/2023.11.10.566670 — Posted: 2024-03-28
SpatialCells: Automated Profiling of Tumor Microenvironments with Spatially Resolved Multiplexed Single-Cell Data
Wan, G., Maliga, Z., Yan, B., Vallius, T., Shi, Y., Khattab, S., Chang, C., Nirmal, A. J., Yu, K.-H., Liu, D., Lian, C. G., DeSimone, M. S., Sorger, P. K., Semenov, Y. R.
10.1101/2023.11.10.566378 — Posted: 2023-11-14

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