COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,082 Articles (22,658 medRxiv, 8,424 bioRxiv)

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Preferential boosting of SARS-CoV-2 Omicron lineage-specific immune responses by monovalent XBB.1.5 vaccination
Geers, D., Aguilar-Bretones, M., Zaeck, L. M., Gill, P. A., Gonzalez-Lopez, C., Handrejk, K., Tan, N. H., den Hartog, Y., Gommers, L., Bogers, S., Mykytyn, A. Z., Sablerolles, R. S. G., Goorhuis, A., Postma, D. F., Visser, L. G., Dalm, V. A. S. H., Lafeber, M., Kootstra, N. A., van Baarle, D., Haagmans, B. L., Koopmans, M. P. G., GeurtsvanKessel, C. H., van der Kuy, P. H. M., van Nierop, G. P., van Zelm, M. C., de Vries, R. D.
10.1101/2025.10.30.25339006 — Posted: 2025-11-02
Psycho-social and behavioral trends in Type 2 Diabetes self-management amongst medically underserved patients during the COVID-19 pandemic in an mHealth intervention
Campbell, E., Jia, H., Cassells, A., Lin, T., Cortez Lainez, J., Tobin, J. N., Smaldone, A., Desai, P., Hripcsak, G., Mamykina, L.
10.1101/2025.10.28.25338894 — Posted: 2025-11-02
Refined fully automated RT-qPCR assay for simultaneous detection of SARS-CoV-2, Influenza A/B, and RSV with target optimization for improved variant resilience
Pfefferle, S., Giersch, K., Noerz, D. S., Grunwald, M., Tang, H. T., Pflueger, L. S., Luetgehetmann, M.
10.1101/2025.10.29.25339068 — Posted: 2025-10-31
Fine-tuned Protein Language Model Identifies Antigen-specific B Cell Receptors from Immune Repertoires
Paco, K., Mendivil, M. P., Zhang, Z., Zebardast, S., Davila, C., Mooney, R. M., Olatoyinbo, P., Yang, T., Bassi, S., Gonzales, V., Chen, E., Ashraf, F. B., Roman, I. C., Felix, J. R., Alam, R. M., Lay, J. A., Johal, M. S., Le Roch, K. G., Tolstorukov, I., Hernandez, J. B., da Silva, F. L. B., Lonardi, S., Sazinsky, M. H., Ray, A.
10.1101/2025.10.30.685465 — Posted: 2025-10-31
Mechanism of substrate binding by the SARS-CoV-2 NiRAN domain and modulation of its activities during replication
Uday, A., Navas, M., Sivaprasad, P. S., Bhat, U., Saikrishnan, K.
10.1101/2025.10.31.685727 — Posted: 2025-10-31
Multimodal single-cell analysis following SARS-CoV-2 breakthrough infection reveals distinct B cell populations
Graus, L. T. M., Guerra, D., Chrysostomou, A., Kerster, G., van der Straten, K., van Rijswijk, J., Tejjani, K., Beaumont, T., Bree, G. J., Sanders, R. W., van Gils, M. J., Claireaux, M.
10.1101/2025.10.30.685644 — Posted: 2025-10-31
Efficacy and Safety of Vitamin D for COVID-19: A Living Evidence Synthesis Baseline report
Sabalete, T., Blasco, J. A., Rodriguez, R., Rosario, M. P., Rojas Reyes, M. X.
10.1101/2025.10.24.25338314 — Posted: 2025-10-30
Genetic Diversity Drives the Rate and Fitness Jumps of Detectable SARS-CoV-2 Recombination
Smith, K., Gangwar, P., Wertheim, J. O., Turakhia, Y.
10.1101/2025.10.28.25338993 — Posted: 2025-10-30
Persistent Spike antigenemia is not associated with Post-COVID condition
Coppens, L., Gorska, A., Hotterbeekx, A., Canziani, L. M., Mateescu, V. O., Gentilotti, E., Pirici, D., Berkell, M., Orchestra Biomarker Study Group, , Malhotra, S., Tacconelli, E., Kumar-Singh, S.
10.1101/2025.10.24.25338528 — Posted: 2025-10-30
Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site
Wang, L., Joseph, J., Vasquez, S., Wrapp, D., Sheahan, T. P., Dzuvor, C. K. O., Rosen, O., Kirchdoerfer, R., Abiona, O. M., Hammond, C., Shi, W., Moak, S. P., Kong, W.-P., Zhang, Y., Eso, M. R., Brown, A. J., Ward, A., Baric, R. S., McLellan, J. S., Pierson, T. C., Mascola, J., Graham, B. S., Yassine, H., Barnes, C. O., Corbett-Helaire, K. S.
10.1101/2025.10.29.685445 — Posted: 2025-10-30

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).