COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,668 Articles (22,913 medRxiv, 8,755 bioRxiv)

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Localized Rigidification and Allosteric Modulation Mechanisms of SARS-CoV-2 Spike Neutralization by Class 3 and Class 4 Antibodies at Atomic Resolution: An Integrated Computational Study of Binding, Dynamics, and Allostery
Alshahrani, M., Gatlin, W., Ludwick, M., Turano, L., Foley, B., Verkhivker, G.
10.64898/2026.07.12.738055 — Posted: 2026-07-21
A historical cross-border Andes virus lineage reveals the origin of a cruise ship hantavirus pulmonary syndrome outbreak
Ramos, H., Diaz-Gavidia, C., Diaz-Ramirez, D., Fuentes-Luppichini, E., Kuhn, J. H., Bellomo, C. M., Schüller, A., Araya-Secchi, R., International Genomics Consortium Investigating the M/V Hondius Outbreak, , Cisterna, D. M., Fernandez-Bettelli, L., Palacios-Aliggi, S., Martinez, V. P., Ferres, M., Maes, P., Palacios, G., Tischler, N. D., Angulo, J.
10.64898/2026.07.19.739363 — Posted: 2026-07-21
Coronavirus papain-like protease antagonizes innate immunity by cleaving Importin α1 to disrupt nuclear transport
Liao, Y., Wang, J., Xue, W., Sun, Y., Tan, L., Song, C., Qiu, X., Ding, C.
10.64898/2026.07.17.739146 — Posted: 2026-07-20
A human monoclonal antibody from hybrid immunity exhibits exceptional neutralization breadth against antigenically divergent contemporary Omicron JN.1 lineage variants
Rathour, D., Shrivas, S., Kumar, N., Prasad, C., Singh, J., Singh, G., Surendranath, A., Rathi, S., Verma, S., Chauhan, S., Singh, B., Sutar, J., Chattopadhyay, S., Batra, G., Sonar, S., Eckerle, I., Subbissi, L., Mohan, A., Asthana, S., Deshpande, S., BHATTACHARYA, J.
10.64898/2026.07.20.739483 — Posted: 2026-07-20
Variant-specific spike conformational dynamics shape memory B cell selection during recall
Broutin, M., Sokal, A., Dejoux, A., Planas, D., Vanderkerken, M., Fernandez, I., Azzaoui, I., Vandenberghe, A., Charlet, M., Arbabian, A., Megret, J., Toure, L., Planchais, C., Berard, L., Simon, T., Weill, J.-C., Mouquet, H., Schwartz, O., Bruhns, P., Rey, F. A., Launay, O., Mahevas, M., Chappert, P.
10.64898/2026.07.18.739204 — Posted: 2026-07-20
Sustained Delivery of a SARS-CoV-2 Subunit Vaccine in An Adjuvanted Hydrogel Depot Enhances Vaccine Responses in Nonhuman Primates
Ou, B. S., Hu, M., Yan, J., Santagata, J. M., Saouaf, O. M., Eppler, H. B., Lujan, V., Song, Y. E., Grifoni, A., Klich, J., Sette, A., Utz, A., Suthar, M. S., Eckman, N., Feng, Y., Baillet, J., Rogers, K. A., Shirreff, L. M., Aoyagi, G. J., Valdez, A. S., Ravichandran, R., King, N. P., Fontenot, J., Villinger, F., Pulendran, B., Appel, E.
10.64898/2026.07.17.736840 — Posted: 2026-07-20
Direct estimation of genotype fitness from time series
Mohanty, V., Shakhnovich, E.
10.64898/2026.07.18.739367 — Posted: 2026-07-20
Long-term SARS-CoV-2 Persistence in Syrian Hamsters
Melquiades de Lima, T., Capelini Eli Lopes, C. E., Oliveira de Souza, M. V., Rocha do Nascimento, F., Meria Ramos Rodrigues, D., Conde Silva, G., Dias, M., Antonio Nasser Neto, T., Silva, M. L., Macedo de Melo Jorge, D., de Paula Souza, J., Arruda, E.
10.64898/2026.07.19.739454 — Posted: 2026-07-20
Anticipatory discovery of entry inhibitors against emerging viruses guided by viral phylogeny
Arce, R., Andreu-Moreno, I., Dufloo, J., Sanjuan, R.
10.64898/2026.07.17.739150 — Posted: 2026-07-20
Human coronavirus nucleocapsid proteins have disparate innate immune evasion abilities
Sharlin, N., Mulloy, R. P., Day, M., Corcoran, J.
10.64898/2026.07.14.738543 — Posted: 2026-07-16

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Subject Areas
* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).