Channel:  Francis Crick Institute

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

513 Articles

Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity reveals structural factors responsible for differences in amino acid preferences between peptide-based substrates and covalent inhibitors.
de Vries, L. E., Sanchez, M. I., Groborz, K., Kuppens, L., Poreba, M., Lehmann, C., Yuan, F., Arastu-Kapur, S., Horn, M., Mares, M., Bogyo, M., Drag, M., Deu, E.
10.1101/246124 — Posted: 2018-08-10
Target-specific precision of CRISPR-mediated genome editing
Chakrabarti, A. M., Henser-Brownhill, T., Monserrat, J., Poetsch, A. R., Luscombe, N. M., Scaffidi, P.
10.1101/387027 — Posted: 2018-08-09
Mapping the human kinome in response to DNA damage
Owusu, M., Bannauer, P., Mourikis, A., Jones, A., Ferreira da Silva, J., Caldera, M., Wiedner, M., Lardeau, C.-H., Menche, J., Kubicek, S., Ciccarelli, F., Loizou, J.
10.1101/385344 — Posted: 2018-08-06
Nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Agapova, A., Hunt, D. M., Petridis, M., Garza-Garcia, A., Sohaskey, C. D., Carvalho, L. P.
10.1101/385278 — Posted: 2018-08-05
Generative adversarial networks simulate gene expression and predict perturbations in single cells
Ghahramani, A., Watt, F. M., Luscombe, N. M.
10.1101/262501 — Posted: 2018-07-30
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Macpherson, J. A., Theisen, A., Masino, L., Fets, L., Driscoll, P. C., Encheva, V., Snijders, A. P., Martin, S. R., Kleinjung, J., Barran, P. E., Fraternali, F., Anastasiou, D.
10.1101/378133 — Posted: 2018-07-26
Neutral tumor evolution?
Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A. M., Markowetz, F., Spellman, P. T., Morris, Q. D., Lingjaerde, O. C., Wedge, D. C., Van Loo, P., PCAWG Evolution and Heterogeneity Working Group
10.1101/158006 — Posted: 2018-07-23
Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
Carvalho, L. P., Evangelopoulos, D., Prosser, G., Rodgers, A., Dagg, B., Khatri, B., Ho, M. M., Gutierrez, M., Cortes, T.
10.1101/374215 — Posted: 2018-07-23
γ-proteobacteria eject their polar flagella under nutrient depletion, retaining flagellar motor relic structures
Ferreira, J. L., Gao, F. Z., Rossmann, F. M., Nans, A., Brenzinger, S., Hosseini, R., Briegel, A., Thormann, K. M., Rosenthal, P. B., Beeby, M.
10.1101/367458 — Posted: 2018-07-18
Bcl6 promotes neurogenic conversion through transcriptional repression of multiple self-renewal-promoting extrinsic pathways.
Bonnefont, J., Tiberi, L., van den Ameele, J., Potier, D., Gaber, Z., Lin, X., Bilheu, A., Herpoel, A., Velez Bravo, F., Guillemot, F., Aerts, S., Vanderhaeghen, P.
10.1101/370999 — Posted: 2018-07-18

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