Channel:  Francis Crick Institute

1,148 Articles

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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing
Adams, S., Purkiss, A. G., Knowles, P. P., Nans, A., Briggs, D. C., Borg, A., Earl, C. P., Goodman, K. M., Nawrotek, A., Borg, A. J., McIntosh, P. B., Houghton, F. M., Kjaer, S., McDonald, N. Q.
10.1101/2020.09.13.286047 — Posted: 2020-09-13
Telomere-to-telomere assembly of the genome of an individual Oikopleura dioica from Okinawa using Nanopore-based sequencing
Bliznina, A., Masunaga, A., Mansfield, M. J., Tan, Y., Liu, A. W., West, C., Rustagi, T., Chien, H.-C., Kumar, S., Pichon, J., Plessy, C., Luscombe, N. M.
10.1101/2020.09.11.292656 — Posted: 2020-09-12
Acute depletion of METTL3 identifies a role for N6-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome
Wei, G., Almeida, M., Pintacuda, G., Coker, H., Bowness, J. S., Ule, J., Brockdorff, N.
10.1101/2020.09.10.291179 — Posted: 2020-09-11
The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis
Kerloch, T., Farrugia, F., Maitre, M., Terral, G., Koehl, M., Heng, J. I.-T., Blanchard, M., Doat, H., Leste-Lasserre, T., Goron, A., Gonzales, D., Guillemot, F., Abrous, N., Pacary, E.
10.1101/2020.09.10.290866 — Posted: 2020-09-10
Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease.
Virdi, G. S., Choi, M. L., Yao, Z., Evans, J. R., Athauda, D., Melandri, D., Sylantyev, S., Abramov, A. Y., Patani, R., Gandhi, S.
10.1101/2020.09.08.287797 — Posted: 2020-09-08
Generating single-sex litters: development of CRISPR-Cas9 genetic tools to produce all-male offspring
Douglas, C., Maciulyte, V., Zohren, J., Snell, D. M., Ojarikre, O. A., Ellis, P. J., Turner, J. M. A.
10.1101/2020.09.07.285536 — Posted: 2020-09-07
Plasmodium falciparum guanylyl cyclase-alpha and the activity of its appended P4-ATPase domain are essential for cGMP synthesis and blood stage egress
Nofal, S. D., Patel, A., Blackman, M. J., Flueck, C., Baker, D. A.
10.1101/2020.09.07.285734 — Posted: 2020-09-07
Assessing the acoustic behaviour of Anopheles gambiae s.l. dsxF mutants: Implications for Vector Control
Su, M. P., Georgiades, M., Bagi, J., Kyrou, K., Crisanti, A., Albert, J.
10.1101/2020.09.06.284679 — Posted: 2020-09-06
Training a neural network to learn other dimensionality reduction removes data size restrictions in bioinformatics and provides a new route to exploring data representations
Dexter, A., Thomas, S. A., Steven, R. T., Robinson, K. N., Taylor, A. J., Elia, E., Nikula, C., Campbell, A. D., Panina, Y., Najumudeen, A. K., Murta, T., Yan, B., Grabowski, P., Hamm, G., Swales, J., Gilmore, I., Yuneva, M., Goodwin, R. J. A., Barry, S., Sansom, O. J., Takats, Z., Bunch, J.
10.1101/2020.09.03.269555 — Posted: 2020-09-03
A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses
Tan, T. K., Rijal, P., Rahikainen, R., Keeble, A., Schimanski, L., Hussain, S., Harvey, R., Hayes, J., Edwards, J., McLean, R., Martini, V., Pedrera, M., Thakur, N., Conceicao, C., Dietrich, I., Shelton, H., Ludi, A. B., Wilsden, G., Browning, C., Zagrajek, A., Bialy, D., Bhat, S., Stevenson-Leggett, P., Hollinghurst, P., Tully, M., Moffat, K., Chiu, C., Waters, R., Gray, A., Azhar, M., Mioulet, V., Newman, J., Asfor, A. S., Burman, A., Crossley, S., Hammond, J., Tchilian, E., Charleston, B., Bailey, D., Tuthill, T. J., Graham, S., Malinauskas, T., Huo, J., Tree, J., Buttigieg, K., Owens, R.
10.1101/2020.08.31.275701 — Posted: 2020-08-31

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