Channel:  Francis Crick Institute

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Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease
Beale, R., Bertolin, A. P., Canal, B., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438811 — Posted: 2021-04-08
Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization
Brown, A.-L., Wilkins, O. G., Keuss, M. J., Hill, S. E., Zanovello, M., Lee, W. C., Lee, F. C. Y., Masino, L., Qi, Y. A., Bryce-Smith, S., Bampton, A., Gatt, A., Phatnani, H., NYGC ALS Consortium, , Schiavo, G., Fisher, E. M. C., Raj, T., Secrier, M., Lashley, T., Ule, J., Buratti, E., Humphrey, J., Ward, M. E., Fratta, P.
10.1101/2021.04.02.438170 — Posted: 2021-04-04
Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma
East, P., Kelly, G., Biswas, D., Marani, M., Hancock, D. C., Creasy, T., Sachsenmeier, K., Swanton, C., de Carne Trecesson, S., Downward, J.
10.1101/2021.04.02.437896 — Posted: 2021-04-04
Biallelic mutations in cancer genomes reveal local mutational determinants
Demeulemeester, J., Dentro, S. C., Gerstung, M., Van Loo, P.
10.1101/2021.03.29.437407 — Posted: 2021-03-30
Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.
Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Ferrarese, R., Sisti, S., Clementi, N., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Marongiu, L., Facchini, F., Bottazzi, A., Fossali, T., Colombo, R., Clementi, M., Tagliabue, E., Pontiroli, A., Meloni, F., Wack, A., Mancini, N., Zanoni, I.
10.1101/2021.03.30.437173 — Posted: 2021-03-30
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
Mantziou, V., Baillie-Benson, P., Jaklin, M., Kustermann, S., Martinez Arias, A., Moris, N.
10.1101/2021.03.30.437698 — Posted: 2021-03-30
N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers
Lueg, G. A., Faronato, M., Gorelik, A., Goya Grocin, A., Caamano-Gutierrez, E., Falciani, F., Solari, R., Carr, R., Bell, A. S., Bartlett, E., Hutton, J. A., Llorian-Sopena, M., Chakravarty, P., Brzezicha, B., Janz, M., Garnett, M. J., Calado, D. P., Tate, E. W.
10.1101/2021.03.20.436222 — Posted: 2021-03-20
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration
Guedan, A., Donaldson, C. D., Cosnefroy, O., Taylor, I. A., Bishop, K. N.
10.1101/2021.03.18.436028 — Posted: 2021-03-18
Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid
Prior, K. F., Middleton, B., Owolabi, A. T., Westwood, M. L., Holland, J., O'Donnell, A. J., Blackman, M. J., Skene, D. J., Reece, S. E.
10.1101/2020.08.24.264689 — Posted: 2021-03-17
Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation
Modic, M., los Mozos, I. R. d., Steinhauser, S., van Genderen, E., Schirge, S., Bergant, V., Ryan, J., Mulholland, C. B., Lee, F. C. Y., Faraway, R., Klobucar, T., Merl-Pham, J., Hauck, S. M., Drukker, M., Bultmann, S., Leonhardt, H., Lickert, H., Luscombe, N. M., ten Berge, D., Ule, J.
10.1101/2021.03.15.433780 — Posted: 2021-03-16

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