Channel:  Francis Crick Institute

1,157 Articles

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Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of oesophageal cancer
Ganguli, P., Colomina-Basanta, C., Acha-Sagrado, A., Misetic, H., Armero-Pineiro, M., Mendez, A., Zahra, A., Devonshire, G., Kelly, G., Freeman, A., Green, M., Nye, E., Bichisecchi, A., Bonfanti, P., Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, , Rodriguez-Justo, M., Spencer, J., Fitzgerald, R. C., Ciccarelli, F. D.
10.1101/2024.01.24.576991 — Posted: 2024-08-08
Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective Proteostasis
Korbonits, M., Wang, X., Barry, S., Lim, C., Suleyman, O., De-Tito, S., Begum, N., Vignola, M. L., Hall, C., Perna, L., Chapple, P., Henson, S., Morales, V., Bianchi, K., Edvardsson, V. O., Ragnarsson, K. A., Kristinsdottir, V. E., Debeer, A., Sleyp, Y., Zinchenko, R., Anderson, G., Duchen, M., Singh, K., Chung, C.-Y., Yuan, Y., Patel, S., Aksoy, E., Borovikov, A. O., Bjornsson, H. T., Van Esch, H., Czibik, G., Tooze, S., Brennan, C. H., Haworth, O.
10.1101/2024.08.08.604602 — Posted: 2024-08-08
Human-like APOBEC3 gene expression and anti-viral responses following replacement of mouse Apobec3 with the 7-gene human APOBEC3 locus
Kirkwood, N. K., Prosser, H., Yap, M. W., Gibson, J., Cook, R., Reddin, I., Stranger, A., Howes, E., Zainal, N., Periyasamy, M., Conticello, S. G., Thomas, G. J., Scott, J., Bishop, K. N., Ali, S., Bradley, A., Fenton, T. R.
10.1101/2024.07.30.605801 — Posted: 2024-08-01
Protein degradation shapes developmental tempo in mouse and human neural progenitors
Nakanoh, S., Stamataki, D., Garcia-Perez, L., Azzi, C., Carr, H. L., Pokhilko, A., Howell, S., Yu, L., Skehel, M., Oxley, D., Andrews, S., Briscoe, J., Rayon, T.
10.1101/2024.08.01.604391 — Posted: 2024-08-01
Multiscale mechanics drive functional maturation of the vertebrate heart
Andrews, T. G., Cornwall Scoones, J., Ramel, M.-C., Gupta, K., Briscoe, J., Priya, R.
10.1101/2024.07.24.604962 — Posted: 2024-07-30
2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism
Alharbi, A., Sapkota, S., Zhang, Z., Jin, R., Jayasekara, W. S., Rupasinghe, E., Speir, M., Wilkinson-White, L., Gamsjaeger, R., Cubeddu, L., Ellyard, J. I., Wenholz, D., McAllan, A., Rezwan, R., Ying, L., Hosseini Far, H., Bones, J., He, S., Yu, D., Lennox, K., Hertzog, P. J., Vinuesa, C., Behlke, M. A., Ohto, U., Laczka, O., Corry, B., Shimizu, T., Gantier, M. P.
10.1101/2024.07.25.605091 — Posted: 2024-07-25
Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics
Biggs, G. S., Cawood, E. E., Vuorinen, A., McCarthy, W. J., Wilders, H., Riziotis, I. G., van der Zouwen, A. J., Pettinger, J., Nightingale, L., Chen, P., Powell, A. J., House, D., Boulton, S. J., Skehel, J. M., Rittinger, K., Bush, J. T.
10.1101/2024.07.25.605137 — Posted: 2024-07-25
ETV4 and ETV5 Orchestrate FGF-Mediated Lineage Specification and Epiblast Maturation during Early Mouse Development
Simon, C. S., Garg, V., Kuo, Y.-Y., Niakan, K. K., Hadjantonakis, A.-K.
10.1101/2024.07.24.604964 — Posted: 2024-07-24
ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
De Tito, S., Almacellas, E., Yu, D. D., Zhang, W., Millard, E., Hervas, J. H., Pellegrino, E., Panagi, I., Fodge, D., Thurston, T. L. M., Gutierrez, M., Tooze, S.
10.1101/2024.07.23.604321 — Posted: 2024-07-24
Structures of TGF-beta with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling
Wieteska, L., Taylor, A. B., Punch, E., Coleman, J. A., Conway, I. O., Lin, Y.-F., Byeon, C.-H., Hinck, C. S., Krzysiak, T., Ishima, R., Lopez-Casillas, F., Cherepanov, P., Bernard, D. J., Hill, C. S., Hinck, A. P.
10.1101/2024.07.19.604101 — Posted: 2024-07-22

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