Channel:  The Howard Hughes Medical Institute (HHMI)

2,511 Articles

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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
Harjes, S., Kurup, H. M., Rieffer, A. E., Bayarjagal, M., Filitcheva, J., Su, Y., Hale, T. K., Filichev, V. V., Harjes, E., Harris, R. S., Jameson, G. B.
10.1101/2023.02.17.528918 — Posted: 2023-02-17
Regulated assembly and neurosteroid modulation constrain GABAA receptor pharmacology in vivo
Sun, C., Zhu, H., Clark, S. A., Gouaux, E.
10.1101/2023.02.16.528867 — Posted: 2023-02-16
Redox Regulation of m6A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Gaffrey, M. J., Kahraman, S., Wei, J., Hu, J., Basile, G., Xiao, L., Rana, T. M., Mathews, C. E., Powers, A. C., Atkinson, M. A., Eizirik, D. L., Dhe-Paganon, S., Parent, A. V., Qian, W.-J., He, C., Kulkarni, R. N.
10.1101/2023.02.16.528701 — Posted: 2023-02-16
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Li, Y.-D., Ma, M. W., Hassan, M. M., Hunkeler, M., Teng, M., Puvar, K., Lumpkin, R., Sandoval, B., Jin, C. Y., Ficarro, S. B., Wang, M. Y., Xu, S., Groendyke, B. J., Sigua, L. H., Tavares, I., Zou, C., Tsai, J. M., Park, P. M. C., Yoon, H., Majewski, F. C., Marto, J. A., Qi, J., Nowak, R. P., Donovan, K. A., Slabicki, M., Gray, N. S., Fischer, E. S., Ebert, B. L.
10.1101/2023.02.14.528208 — Posted: 2023-02-15
Transmembrane protein CD69 acts as an S1PR1 agonist
Chen, H., Qin, Y., Chou, M., Cyster, J. G., Li, X.
10.1101/2023.02.13.528406 — Posted: 2023-02-15
Ormdl3 regulation of specific ceramides is dispensable for β-cell function and glucose homeostasis under obesogenic conditions
Hurley, L. D., Lee, H., Wade, G., Simcox, J., Engin, F.
10.1101/2023.02.11.528130 — Posted: 2023-02-11
Effects of Antibiotic Interaction on Antimicrobial Resistance Development in Wastewater
Sutradhar, I., Ching, C., Desai, D., Heins, Z., Khalil, A. S., Zaman, M. H.
10.1101/2023.02.10.528009 — Posted: 2023-02-10
RNA-catalyzed RNA Ligation within Prebiotically Plausible Model Protocells
DasGupta, S., Zhang, S. J., Smela, M. P., Szostak, J. W.
10.1101/2023.02.09.527907 — Posted: 2023-02-09
Multiplicity of Agrobacterium infection of Nicotiana benthamiana for transient DNA delivery
Carlson, E., Rajniak, J., Sattely, E.
10.1101/2023.02.07.527564 — Posted: 2023-02-08
Selection of a de novo gene that can promote survival of E. coli by modulating protein homeostasis pathways
Frumkin, I., Laub, M. T.
10.1101/2023.02.07.527531 — Posted: 2023-02-07

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