Channel:  The Howard Hughes Medical Institute (HHMI)

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Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases
Durfee, C., Temiz, N. A., Levin-Klein, R., Argyris, P., Alsoe, L., Carracedo, S., Alonso, A., Proehl, J., Holzhauer, A., Seeman, Z., Lin, Y.-H. T., Vogel, R. I., Sotillo, R., Nilsen, H., Harris, R.
10.1101/2023.02.24.529970 — Posted: 2023-02-25
O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations
Huynh, D. T., Hu, J., Schneider, J. R., Tsolova, K. N., Soderblom, E. J., Watson, A. J., Chi, J.-T. A., Evans, C. S., Boyce, M.
10.1101/2023.02.22.529563 — Posted: 2023-02-22
Enterovirus Evolution Reveals the Mechanism of an RNA-Targeted Antiviral and Determinants of Viral Replication
Davila-Calderon, J., Li, M.-L., Penumutchu, S., Haddad, C., Malcolm, L., Hargrove, A. E., Brewer, G., Tolbert, B. S.
10.1101/2023.02.20.529064 — Posted: 2023-02-20
Marginal specificity in protein interactions constrains evolution
Ghose, D. A., Przydzial, K. E., Mahoney, E. M., Keating, A. E., Laub, M. T.
10.1101/2023.02.18.529082 — Posted: 2023-02-19
Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening
Fiorin, G., Forrest, L. R., Faraldo-Gomez, J. D.
10.1101/2023.02.02.525347 — Posted: 2023-02-17
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
Harjes, S., Kurup, H. M., Rieffer, A. E., Bayarjagal, M., Filitcheva, J., Su, Y., Hale, T. K., Filichev, V. V., Harjes, E., Harris, R. S., Jameson, G. B.
10.1101/2023.02.17.528918 — Posted: 2023-02-17
Redox Regulation of m6A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Gaffrey, M. J., Kahraman, S., Wei, J., Hu, J., Basile, G., Xiao, L., Rana, T. M., Mathews, C. E., Powers, A. C., Atkinson, M. A., Eizirik, D. L., Dhe-Paganon, S., Parent, A. V., Qian, W.-J., He, C., Kulkarni, R. N.
10.1101/2023.02.16.528701 — Posted: 2023-02-16
Regulated assembly and neurosteroid modulation constrain GABAA receptor pharmacology in vivo
Sun, C., Zhu, H., Clark, S. A., Gouaux, E.
10.1101/2023.02.16.528867 — Posted: 2023-02-16
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Li, Y.-D., Ma, M. W., Hassan, M. M., Hunkeler, M., Teng, M., Puvar, K., Lumpkin, R., Sandoval, B., Jin, C. Y., Ficarro, S. B., Wang, M. Y., Xu, S., Groendyke, B. J., Sigua, L. H., Tavares, I., Zou, C., Tsai, J. M., Park, P. M. C., Yoon, H., Majewski, F. C., Marto, J. A., Qi, J., Nowak, R. P., Donovan, K. A., Slabicki, M., Gray, N. S., Fischer, E. S., Ebert, B. L.
10.1101/2023.02.14.528208 — Posted: 2023-02-15
Transmembrane protein CD69 acts as an S1PR1 agonist
Chen, H., Qin, Y., Chou, M., Cyster, J. G., Li, X.
10.1101/2023.02.13.528406 — Posted: 2023-02-15

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