Channel:  The Howard Hughes Medical Institute (HHMI)

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The Molecular Architecture of the Nuclear Basket
Singh, D., Soni, N., Hutchings, J., Echeverria, I., Shaikh, F., Duquette, M., Suslov, S., Li, Z., van Eeuwen, T., Molloy, K., Shi, Y., Wang, J., Guo, Q., Chait, B. T., Fernandez-Martinez, J., Rout, M. P., Sali, A., Villa, E.
10.1101/2024.03.27.587068 — Posted: 2024-03-28
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders
Jurgens, J. A., Barry, B. J., Chan, W.-M., MacKinnon, S., Whitman, M. C., Matos Ruiz, P. M., Pratt, B. M., England, E. M., Pais, L., Lemire, G., Groopman, E., Glaze, C., Russell, K. A., Singer-Berk, M., Di Gioia, S. A., Lee, A. S., Andrews, C., Shaaban, S., Wirth, M. M., Bekele, S., Toffoloni, M., Bradford, V. R., Foster, E. E., Berube, L., Rivera-Quiles, C., Mensching, F. M., Sanchis-Juan, A., Fu, J. M., Wong, I., Zhao, X., Wilson, M. W., Weisburd, B., Lek, M., Ocular CCDD Phenotyping Consortium, , Brand, H., Talkowski, M. E., MacArthur, D. G., O'Donnell-Luria, A., Robson, C. D., Hunter, D.
10.1101/2024.03.22.24304594 — Posted: 2024-03-26
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan
Jayne, L., Lavin-Peter, A., Roessler, J., Tyshkovskiy, A., Antoszewski, M., Ren, E., Markovski, A., Sun, S., Yao, H., Sankaran, V. G., Gladyshev, V. N., Brooke, R. T., Horvath, S., Griffith, E. C., Hrvatin, S.
10.1101/2024.03.20.585828 — Posted: 2024-03-25
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
Singh, S., Dransfeld, U., Ambaw, Y., Lopez-Scarim, J., Farese, R. V., Walther, T. C.
10.1101/2024.03.21.586175 — Posted: 2024-03-21
CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality
Tien, J. C.-Y., Chang, Y., Zhang, Y., Chou, J., Cheng, Y., Wang, X., Yang, J., Mannan, R., Shah, P., Wang, X.-M., Todd, A. J., Eyunni, S., Cheng, C., Rebernick, R. J., Xiao, L., Bao, Y., Neiswender, J., Brough, R., Pettitt, S. J., Cao, X., Miner, S. J., Zhou, L., Wu, Y.-M., Labanca, E., Wang, Y., Parolia, A., Cieslik, M., Robinson, D. R., Wang, Z., Feng, F. Y., Lord, C. J., Ding, K., Chinnaiyan, A. M.
10.1101/2024.03.20.585990 — Posted: 2024-03-21
Structural and genetic diversity in the secreted mucins, MUC5AC and MUC5B
Plender, E. G., Prodanov, T., Hsieh, P., Nizamis, E., Harvey, W. T., Sulovari, A., Munson, K. M., Kaufman, E., O'Neal, W. K., Valdmanis, P. N., Marschall, T., Eichler, E. E.
10.1101/2024.03.18.585560 — Posted: 2024-03-20
Effects of protein G-quadruplex interactions on phase transitions and protein aggregation
Sahoo, B., Kocman, V., Clark, N., Myers, N., Deng, X., Wong, E. L., Yang, H. J., Kotar, A., Guzman, B. B., Dominguez, D. C., Plavec, J., Bardwell, J. C.
10.1101/2023.09.21.558871 — Posted: 2024-03-20
Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
Xue, Y., Zhou, Y., Cepko, C. L.
10.1101/2023.08.03.551766 — Posted: 2024-03-20
Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer
Lee, E., Zhang, Z., Chen, C.-C., Choi, D., Rivera, A. C. A., Linton, E., Ho, Y.-j., Love, J., LaClair, J., Wongvipat, J., Sawyers, C.
10.1101/2024.03.18.585532 — Posted: 2024-03-20
Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Cheng, C., Hu, J., Mannan, R., Bhattacharyya, R., Rossiter, N. J., Magnuson, B., Wisniewski, J. P., Zheng, Y., Xiao, L., Li, C., Awad, D., He, T., Bao, Y., Zhang, Y., Cao, X., Wang, Z., Mehra, R., Morlacchi, P., Sahai, V., Pasca di Magliano, M., Shah, Y. M., Ding, K., Qiao, Y., Lyssiotis, C. A., Chinnaiyan, A. M.
10.1101/2024.03.18.585580 — Posted: 2024-03-20

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