Channel:  The Howard Hughes Medical Institute (HHMI)

2,325 Articles

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NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis
Parolia, A., Eyunni, S., Verma, B. K., Young, E., Liu, L., George, J., Aras, S., Das, C. K., Mannan, R., ur Rasool, R., Luo, J., Carson, S. E., Mitchell-Velasquez, E., Liu, Y., Xiao, L., Gajjala, P. R., Jaber, M., Wang, X., He, T., Qiao, Y., Pang, M., Zhang, Y., Alhusayan, M., Cao, X., Tavana, O., Hou, C., Wang, Z., Ding, K., Chinnaiyan, A. M., Asangani, I. A.
10.1101/2024.02.22.581560 — Posted: 2024-03-29
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimers disease brain by a strain-relief mechanism
Hou, K., Ge, P., Sawaya, M. R., Dolinsky, J. L., Yang, Y., Jiang, Y. X., Lutter, L., Boyer, D. R., Cheng, X., Pi, J., Zhang, J., Lu, J., Yang, S., Yu, Z., Feigon, J., Eisenberg, D. S.
10.1101/2024.03.25.586668 — Posted: 2024-03-29
The Molecular Architecture of the Nuclear Basket
Singh, D., Soni, N., Hutchings, J., Echeverria, I., Shaikh, F., Duquette, M., Suslov, S., Li, Z., van Eeuwen, T., Molloy, K., Shi, Y., Wang, J., Guo, Q., Chait, B. T., Fernandez-Martinez, J., Rout, M. P., Sali, A., Villa, E.
10.1101/2024.03.27.587068 — Posted: 2024-03-28
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders
Jurgens, J. A., Barry, B. J., Chan, W.-M., MacKinnon, S., Whitman, M. C., Matos Ruiz, P. M., Pratt, B. M., England, E. M., Pais, L., Lemire, G., Groopman, E., Glaze, C., Russell, K. A., Singer-Berk, M., Di Gioia, S. A., Lee, A. S., Andrews, C., Shaaban, S., Wirth, M. M., Bekele, S., Toffoloni, M., Bradford, V. R., Foster, E. E., Berube, L., Rivera-Quiles, C., Mensching, F. M., Sanchis-Juan, A., Fu, J. M., Wong, I., Zhao, X., Wilson, M. W., Weisburd, B., Lek, M., Ocular CCDD Phenotyping Consortium, , Brand, H., Talkowski, M. E., MacArthur, D. G., O'Donnell-Luria, A., Robson, C. D., Hunter, D.
10.1101/2024.03.22.24304594 — Posted: 2024-03-26
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan
Jayne, L., Lavin-Peter, A., Roessler, J., Tyshkovskiy, A., Antoszewski, M., Ren, E., Markovski, A., Sun, S., Yao, H., Sankaran, V. G., Gladyshev, V. N., Brooke, R. T., Horvath, S., Griffith, E. C., Hrvatin, S.
10.1101/2024.03.20.585828 — Posted: 2024-03-25
CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality
Tien, J. C.-Y., Chang, Y., Zhang, Y., Chou, J., Cheng, Y., Wang, X., Yang, J., Mannan, R., Shah, P., Wang, X.-M., Todd, A. J., Eyunni, S., Cheng, C., Rebernick, R. J., Xiao, L., Bao, Y., Neiswender, J., Brough, R., Pettitt, S. J., Cao, X., Miner, S. J., Zhou, L., Wu, Y.-M., Labanca, E., Wang, Y., Parolia, A., Cieslik, M., Robinson, D. R., Wang, Z., Feng, F. Y., Lord, C. J., Ding, K., Chinnaiyan, A. M.
10.1101/2024.03.20.585990 — Posted: 2024-03-21
PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
Singh, S., Dransfeld, U., Ambaw, Y., Lopez-Scarim, J., Farese, R. V., Walther, T. C.
10.1101/2024.03.21.586175 — Posted: 2024-03-21
Structural and genetic diversity in the secreted mucins, MUC5AC and MUC5B
Plender, E. G., Prodanov, T., Hsieh, P., Nizamis, E., Harvey, W. T., Sulovari, A., Munson, K. M., Kaufman, E., O'Neal, W. K., Valdmanis, P. N., Marschall, T., Eichler, E. E.
10.1101/2024.03.18.585560 — Posted: 2024-03-20
Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer
Lee, E., Zhang, Z., Chen, C.-C., Choi, D., Rivera, A. C. A., Linton, E., Ho, Y.-j., Love, J., LaClair, J., Wongvipat, J., Sawyers, C.
10.1101/2024.03.18.585532 — Posted: 2024-03-20
Effects of protein G-quadruplex interactions on phase transitions and protein aggregation
Sahoo, B., Kocman, V., Clark, N., Myers, N., Deng, X., Wong, E. L., Yang, H. J., Kotar, A., Guzman, B. B., Dominguez, D. C., Plavec, J., Bardwell, J. C.
10.1101/2023.09.21.558871 — Posted: 2024-03-20

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