Channel:  Impact of Genomic Variation on Function (IGVF)

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

106 Articles

Reimagining Gene-Environment Interaction Analysis for Human Complex Traits
Miao, J., Song, G., Wu, Y., Hu, J., Wu, Y., Basu, S., Andrews, J. S., Schaumberg, K., Fletcher, J. M., Schmitz, L. L., Lu, Q.
10.1101/2022.12.11.519973 — Posted: 2022-12-14
Leveraging a machine learning derived surrogate phenotype to improve power for genome-wide association studies of partially missing phenotypes in population biobanks
McCaw, Z. R., Gao, J. R., Lin, X., Gronsbell, J.
10.1101/2022.12.12.520180 — Posted: 2023-10-05
Ensembled best subset selection using summary statistics for polygenic risk prediction
Chen, T., Zhang, H., Mazumder, R., Lin, X.
10.1101/2023.09.25.559307 — Posted: 2023-09-27
A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies
Li, X., Chen, H., Selvaraj, M. S., Van Buren, E., Zhou, H., Wang, Y., Sun, R., McCaw, Z. R., Yu, Z., Arnett, D. K., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Brody, J. A., Cade, B. E., Carson, A. P., Carlson, J. C., Chami, N., Chen, Y.-D. I., Curran, J. E., de Vries, P. S., Fornage, M., Franceschini, N., Freedman, B. I., Gu, C., Heard-Costa, N. L., He, J., Hou, L., Hung, Y.-J., Irvin, M. R., Kaplan, R. C., Kardia, S. L. R., Kelly, T., Konigsberg, I., Kooperberg, C., Kral, B. G., Li, C., Loos, R. J. F., Mahaney, M. C., Martin, L. W., Mathias, R. A., Minster, R. L., Mitchell, B. D
10.1101/2023.10.30.564764 — Posted: 2023-11-02
Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-Omics for Precision Medicine (TOPMed) Consortium
Jiang, M.-Z., Gaynor, S. M., Li, X., Van Buren, E., Stilp, A., Buth, E., Wang, F. F., Manansala, R., Gogarten, S. M., Li, Z., Polfus, L. M., Salimi, S., Bis, J. C., Pankratz, N., Yanek, L. R., Durda, P., Tracy, R. P., Rich, S. S., Rotter, J. I., Mitchell, B. D., Lewis, J. P., Psaty, B. M., Pratte, K. A., Silverman, E. K., Kaplan, R. C., Avery, C., North, K., Mathias, R. A., Faraday, N., Lin, H., Wang, B., Carson, A. P., Norwood, A. F., Gibbs, R. A., Kooperberg, C., Lundin, J., Peters, U., Dupuis, J., Hou, L., Fornage, M., Benjamin, E. J., Reiner, A. P., Bowler, R. P., Lin, X., Auer, P. L., Raf
10.1101/2023.09.10.555215 — Posted: 2023-09-12
A new method for multi-ancestry polygenic prediction improves performance across diverse populations
Zhang, H., Zhan, J., Jin, J., Zhang, J., Lu, W., Zhao, R., Ahearn, T. U., Yu, Z., O'Connell, J., Jiang, Y., Chen, T., Okuhara, D., 23andMe Research Team, , Garcia-Closas, M., Lin, X., Koelsch, B. L., Chatterjee, N.
10.1101/2022.03.24.485519 — Posted: 2023-08-17
Accurate and Efficient Estimation of Local Heritability using Summary Statistics and LD Matrix
Li, H., Mazumder, R., Lin, X.
10.1101/2023.02.08.527759 — Posted: 2023-03-22
De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding
Alexandari, A. M., Horton, C. A., Shrikumar, A., Shah, N., Li, E., Weilert, M., Pufall, M. A., Zeitlinger, J., Fordyce, P. M., Kundaje, A.
10.1101/2023.05.11.540401 — Posted: 2023-05-11
5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cells
Wei, A., Zhang, H., Qiu, Q., Fabyanic, E. B., Hu, P., Wu, H.
10.1101/2023.09.26.559662 — Posted: 2023-09-27
A transient dermal niche and dual epidermal programs underlie sweat gland development
Dingwall, H. L., Tomizawa, R. R., Aharoni, A., Hu, P., Qiu, Q., Kokalari, B., Martinez, S. M., Donahue, J. C., Aldea, D., Mendoza, M., Glass, I. A., Birth Defects Research Laboratory, , Wu, H., Kamberov, Y. G.
10.1101/2023.04.15.537037 — Posted: 2023-04-17

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