COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,184 Articles (22,713 medRxiv, 8,471 bioRxiv)

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Long-term N-Acetylcysteine Treatment Accelerates Improvement in Patient-Reported Outcomes for COVID-19 Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
Li, L., zhao, h., Ye, L., He, H., Chai, C., Tong, Y., Zhang, Y.
10.64898/2025.12.10.25342003 — Posted: 2025-12-12
Humoral immunity induced by XEC monovalent vaccines against SARS-CoV-2 variants including XEC, LP.8.1, NB.1.8.1, XFG, and BA.3.2
Uriu, K., Kaku, Y., Kosugi, Y., Chen, L., Itoh, N., Uwamino, Y., Fujiwara, H., Satoh, H., The Genotype to Phenotype Japan (G2P-Japan) Consortium, , Sato, K.
10.64898/2025.12.11.693810 — Posted: 2025-12-12
Estimating Impact of SARS-CoV-2 Infection on Health-Related Quality of Life among Persons Aged 8 years and Older, August 2020-July 2022
Johnson, S., Nguyen, H. Q., Stockwell, M. S., Porucznik, C. A., Karron, R. A., Dawood, F. S., Posser, L. A., Sarakki, A. P., Stanford, J. B., Hetrich, M., Schappell, E., Deloria Knoll, M., Veguilla, V., Mellis, A., Duque, J., Jeddy, Z., Pike, J., Rolfes, M. A.
10.64898/2025.12.10.25341971 — Posted: 2025-12-11
DEMOGRAPHIC & CLINICAL PROFILE OF PATIENTS PRESENTED WITH ACUTE MYOCARDIAL INFARCTION DURING COVID 19 PANDEMIC - A TERTIARY CARE CENTRE STUDY
NORONHA, D., H, H., Kamath, P., Pai, N., Nayak, C. -, Chawla, M., Pahuja, A., Dsouza, R.
10.64898/2025.12.09.25341947 — Posted: 2025-12-11
Lessons for design of digital triage tools from family medicine providers' experiences with COVID-19 self-assessment tools
Austin, L. C., Kfrerer, M. L., Faulds, C., Austin, R. D., Ziebart, C., Pepe, D.
10.64898/2025.12.09.25341895 — Posted: 2025-12-11
Monkeypox Virus Clade IIb Isolate Exhibits Reduced Virulence Relative to Clade IIa Isolates in Multiple Murine Models
Trefry, S. V., Vidal-Freire, S., Awasthi, M., Ordonez, A. D., Eaton, B. P., Raney, C. N., Cregger, A. L., Gonzales, C. A., Enamorado, R. N., Martinez, N. A., Gohegan, D. S., Lackemeyer, M. G., Moulaei, T., Ziolkowska, N. E., Goebel, S. J., Palacios, G. F., Bavari, S., Nasar, F.
10.64898/2025.12.10.693532 — Posted: 2025-12-11
AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies
Yan, Q., Huang, X., Liu, B., Yao, Y., Zheng, H., Song, Y., Wu, F., He, Z., Li, S., Chen, F., Niu, C., Li, Z., Yuan, H., Lin, Y., Chen, L., Zang, N., Xiao, J., Wang, T., Chen, C., Bai, H., Li, J., Wu, M., Zhao, J., Yao, J., Yang, Y., Zhu, A., Zhao, J.
10.64898/2025.12.10.693372 — Posted: 2025-12-10
Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model
Kaiser, F. K., Gallogly, S., Mukesh, R., Ochwoto, M., Yinda, K. C., van Tol, S., Schulz, J., Hawes, K., Bulloch, B., McBain, A., Bushmaker, T., Okumura, A., Prado-Smith, J., Smith, B., Rosenke, K., Saturday, G., Munster, V.
10.64898/2025.12.09.693236 — Posted: 2025-12-09
Conserved phosphorylatable residues in motif G of positive-stranded virus RdRps regulate polymerase activity and suggest targets for drug design.
Duflos, C., Lizcano-Perret, B., Peersen, O., Herinckx, G., Alpizar, Y. A., Vertommen, D., Michiels, T.
10.64898/2025.12.08.692995 — Posted: 2025-12-09
A Secreted Subunit SARS-CoV-2 RBD-CpE Yeast Oral Vaccine Induces an Adaptive Immune Response in BALB/c Mice
Ramos, J. D., Bresnahan, C., Brysgel, T., Kozub, N., Mendoza, G., Murillo, L. C., Devanadera, M. K., Castillo, J., Castillo, D. A., Aguilar, J. P., Rimando, M., Austriaco, N.
10.64898/2025.12.08.692901 — Posted: 2025-12-08

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).