COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,519 Articles (22,870 medRxiv, 8,649 bioRxiv)

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Mechanochemical Decoupling of ATP Hydrolysis and RNA Translocation in SARS-CoV-2 nsp13 by the L405D Mutation
Fazelpour, E., Roy, P., Frederick, K., McCullagh, M.
10.64898/2026.05.18.726016 — Posted: 2026-05-20
Direct serological antibody discovery by integrative proteomics yields potent neutralizers overlooked by single-cell BCR sequencing
Tamara, S., van Rijswijck, D. M. H., van Rijswijk, J., Burger, J. A., Schulte, D., Moreschini, M., de Bree, G. J., van Gils, M. J., Heck, A. J. R., den Boer, M. A.
10.64898/2026.05.20.725438 — Posted: 2026-05-20
Variant emergence, not vaccine deployment, drives episodic positive selection on the SARS-CoV-2 spike at provincial scale in Canada
Tomas, M., Ndongo, C. P. K., Vilain, M., Aris-Brosou, S.
10.64898/2026.05.16.725625 — Posted: 2026-05-19
Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead
Elshan, N. G. R. D., Wolff, K. C., Weiss, F., Ghorai, S., Grabovyi, G., Wilson, K., Riva, L., Woods, A. K., Pedroarena, J., Nazarian, A., Liu, Y., Mazumdar, W., Song, L., Okwor, N., Malvin, J., Bakowski, M. A., Kirkpatrick, M. G., Gebara-Lamb, A., Huang, E., Nguyen-Tran, V. T. B., Chi, V., Li, S., Lee, K.-J., McNamara, C. W., Gupta, A. K., Rahimi, A., Chen, J. J., Joseph, S. B., Schultz, P. G., Chatterjee, A. K.
10.64898/2026.05.15.725542 — Posted: 2026-05-18
Environmental stochasticity can account for patterns of within-host respiratory virus evolution
Xiao, W. F., Farjo, M. N., Lowen, A. C., Koelle, K.
10.64898/2026.05.15.725410 — Posted: 2026-05-18
Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue
Stanton, A. E., Kang, J., Blanchard, J. W., Boix, C. A., Schroeder, M. E., Lee, Y., Su, H., Wang, S., Yu, E., Emenari, A., Peng, Z., Agbas, E., Cerit, O., Park, D., Zhang, R., Bennett, D. A., Yin, P., Kellis, M., Langer, R., Boyden, E., Tsai, L.-H.
10.64898/2026.05.14.725177 — Posted: 2026-05-15
A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation
Kimura, T., Katayama, T., Ishikawa, S., Mitra, S., Yamano, Y., Onizuka, K., Nagatsugi, F., Laha, S., Naganathan, A. N., Itoh, Y., Takahashi, S.
10.64898/2026.05.15.725307 — Posted: 2026-05-15
Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses
Kumar, S., Lai, L., Ellis, M., Patel, A. B., Joshi, D. J., Velden, J. V., Faraj, J. Z. A., Wimalasena, S. T., Pallavi, R. R., Iriss, J., Bechnak, K., Edupuganti, S., Rouphael, N., Ortlund, E., Moreno, A., Menachery, V. D., Zarnitsyna, V. I., Wrammert, J., Suthar, M. S.
10.64898/2026.05.13.725047 — Posted: 2026-05-15
Pathogen-specific host responses define distinct pneumonia endotypes in the human lung
Markov, N. S., Mozejko, M., Guggilla, V., Łazecka, M., Donnelly, H. K., Donayre, A., Fenske, S., Peltekian, A., Puczko-Szymanski, B., Szymczak, P., Izdebski, A., Luo, L., Senkow, K. J., Cusick, L., Yu, Z., Swaminathan, S., Lu, Z., Abdala-Valencia, H., Phan, D., Clepp, R. K., Rasmussen, L. V., Pawlowski, A., Pickens, C. O., Nadig, N. R., Walunas, T., Tighe, R., The Neu-Lung Investigators, , Wunderink, R. G., Budinger, G. S., Morales-Nebreda, L., Gao, C. A., Singer, B. D., Misharin, A. V., Szczurek, E., The NU SCRIPT Study Investigators
10.64898/2026.05.12.724509 — Posted: 2026-05-14
AI-discovered protein fragments as generalizable regulators of biomolecular condensates
Savinov, A., Sadasivan, J., White, K. J., Rubien, J. D., Li, G.-W., Case, L. B.
10.64898/2026.05.08.723928 — Posted: 2026-05-12

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).