COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,788 Articles (22,946 medRxiv, 8,842 bioRxiv)

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Characterizing spatiotemporal patterns of case reporting backfill: a case study of COVID-19 reporting in Michigan, 2020-24
Niu, Y., Brouwer, A. F., Martin, E. T., Coyle, J. R., Eisenberg, M. C.
10.1101/2025.11.25.25340977 — Posted: 2025-11-27
Experience from an HTS campaign: Investigation of susceptibility and rescue of SARS-CoV-2 nsp3 protease assay from metal contamination
Georgiou, I., O'Neill, S., Robinson, C., Cunningham, F., O'Byrne, S. N., Gray, D., Scott, D. E., Gilbert, I. H.
10.1101/2025.11.27.690678 — Posted: 2025-11-27
Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain
Seo, L., Farran, I., Aslam, A., Li, X., Jaishankar, P., Fraser, J. S., Renslo, A., Wankowicz, S. A.
10.1101/2025.11.25.690589 — Posted: 2025-11-26
Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III Trial
Levine, K. S., Blanc, R., Wang, Q., Malca, H., Sekulovich, R., Jin, H., Liu, S., Verhoeven, C., Sullivan, B., Smolenov, I., McNamara, R. P.
10.1101/2025.11.25.690547 — Posted: 2025-11-26
Non-clinical safety of GRAd vector-based COVID-19 and HIV vaccines supports a platform regulatory approach
Capone, S., Paalangara, R., Gohin, S., Menard, A., Amy, C., Berrabah, W., Rogue, A., Getz, M. A., Alrubayyi, A., Battella, S., Raggioli, A., Gentile, M., Di Rita, A., Noto, A., Miselli, G., Grazioli, F., Napolitano, F., Sowcik, D., Soriani, M., Chmielewski, B., Molife, L., Muturi-Kioi, V., Makadzange, A. T., Gaiha, G. D., Ancian, P., Ackland, J., Folgori, A., Colloca, S.
10.1101/2025.11.24.689034 — Posted: 2025-11-24
Uncovering structural determinants of peptide recognition by public and private T-cell receptors
Akil, C., Peng, Y., McCarthy, J., Zhu, Y., Hardenbrook, N., Dong, D., Antoun, E., Yao, X., Liu, G., Chen, J.-l., balikci, E., Cioaca, R., Yang, Y., Mentzer, A. J., Knight, J. C., Fernandes, R., Dong, T., Zhang, P.
10.1101/2025.11.23.690020 — Posted: 2025-11-24
Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability
Coker, J. A., Sun, R., Polzer, P. M., Romigh, T., Goins, C. M., Wang, N. S., Jung, J. U., Stauffer, S. R.
10.1101/2025.11.21.689747 — Posted: 2025-11-24
Key residues in SARS-CoV-2 NSP3 hyper variable region are necessary to modulate early stress granule activity.
Alvarado, R. E., Lokugamage, K. G., Garvanska, D., Estes, L. K., Ahearn, Y. P., McLeland, A., Moayyed, A., Lopez-Mendez, B. D., Plante, J. A., Plante, K. S., Johnson, B. A., Nilsson, J. S., Menachery, V. D.
10.1101/2025.11.22.689758 — Posted: 2025-11-24
Deconvolving SARS-CoV-2 mRNA vaccine impact on immunotherapy-related survival in a pandemic
Jee, J., Zhang, J., Lavery, J., Waters, M., Fong, C., Minn, A., Glickman, M., Panageas, K., Sawyers, C., Schultz, N.
10.1101/2025.11.21.25340753 — Posted: 2025-11-23
Mental disorders, mortality following myocardial infarction and the impact of the COVID-19 pandemic in England: a cohort study
Fleetwood, K., Nolan, J., Berry, C., Cavers, D., Mercer, S. W., Padmanabhan, S., Smith, D. J., Stewart, R., Vettini, A., Jackson, C. A., CVD-COVID-UK/COVID-IMPACT Consortium
10.1101/2025.11.21.25340653 — Posted: 2025-11-22

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).