COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,755 Articles (22,943 medRxiv, 8,812 bioRxiv)

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LinearCapR: Linear-time computation of per-nucleotide structural-context probabilities of RNA without base-pair span limits
Otagaki, T., Hosokawa, H., Fukunaga, T., Iwakiri, J., Terai, G., Asai, K.
10.64898/2025.12.26.696559 — Posted: 2025-12-29
Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens
Kim, J., Correy, G. J., Hall, B. W., Rachman, M. M., Mailhot, O., Togo, T., Gonciarz, R. L., Jaishankar, P., Neitz, R. J., Hantz, E. R., Doruk, Y. U., Stevens, M. G. V., Diolaiti, M. E., Reid, R., Gopalkrishnan, S., Krogan, N. J., Renslo, A. R., Ashworth, A., Shoichet, B. K., Fraser, J. S.
10.64898/2025.12.25.696505 — Posted: 2025-12-28
Combinational adjuvants delivered by ink-jet potentiate naked mRNA vaccines for robust protection against infectious diseases
Qiao, N., Ishikawa, J., Yasui, F., Sano, K., Miyakawa, K., Hayashi, A., Amiry, A. F., Haonan, L., Xueyang, Z., Sato, T., Pasqualini, R., Arap, W., Kataoka, K., Hasegawa, H., Kohara, M., Uchida, S.
10.64898/2025.12.24.696305 — Posted: 2025-12-26
Structural Divergence without Functional Impact: Comparative Characterization of SARS-CoV-2 3CL-Mpro Variants Using Cleavage Site Substrates
Saha, D., Dakhili, S. Y. T., Mar, E., Chen, Y. S., VanPetegem, F., Bromme, D.
10.64898/2025.12.23.696280 — Posted: 2025-12-26
Change in Fatigue over 15 months in people the Post-Covid Syndrome
Mayo, N., Hum, S., Nadeau, L., Brouillette, M.-J., Fellows, L. K.
10.64898/2025.12.20.25342742 — Posted: 2025-12-22
Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells
Brink, H. J., Affandi, A. J., Man, S., Dekker, N. C. C. T., Grosse Wichtrup, E. A., Bouma, R. G., Seyed Toutounchi, N., Konijn, V. A. L., Stolwijk, J. G. C., van Hamme, J. L., Olesek, K., Heijnen, D. A. M., Fish, A., Moutsiopoulou, A., Celie, P., Dekkers, G., Heukers, R., Mastrobattista, E., Smit, M. J., van Kooyk, Y., Heikema, A. P., Kootstra, N. A., Geijtenbeek, T. B. H., den Haan, J. M. M.
10.64898/2025.12.19.695420 — Posted: 2025-12-22
AI Identifies Broadly Neutralizing Antibodies from an IGHV1-69 Public Antibody Class Exerting Continued Selection Over SARS-CoV-2
Niu, C., Huang, X., Yan, Q., Liu, B., Gao, X., Song, Y., Wang, J., Wang, L., Li, Z., Zheng, H., He, P., Huang, X., Yuan, H., Zou, B., Yang, Y., Wu, F., Yao, Y., Habib, G., Chen, X., Chen, L., He, J., Yao, J., Zhao, J., Xiong, X.
10.64898/2025.12.19.695307 — Posted: 2025-12-22
Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types
Furman, S., Zayou, L., Tsourmas, K. I. I., Javonillo, D. I., Olivarria, G. M., Cheng, Y., Pachow, C., Fernandez, K., Le, L., Edwards, R. A., Nicholas, D., Sanchez, G. P., Baric, R. S., Green, K. N., Lane, T. E.
10.64898/2025.12.19.695600 — Posted: 2025-12-22
Including gender-specific features in epidemic modeling: the case of the second wave of COVID-19 in Italy
De Gaetano, A., Coletti, P., Perra, N., Barrat, A., Paolotti, D.
10.64898/2025.12.19.25342675 — Posted: 2025-12-21
Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue
Germann, M., Maffitt, N. J., Burton, O. A., Ashhad, A., Baker, A. M. E., Zaaimi, B., Ng, W.-F., Soteropoulos, D. S., Baker, S. N., Baker, M. R.
10.64898/2025.12.19.25342669 — Posted: 2025-12-21

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).