COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,157 Articles (22,703 medRxiv, 8,454 bioRxiv)

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Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection
ELTOBGY, M., Shamseldin, M., Whitham, O., Amer, H., Atkinson, J., Badr, A., Hall, J., Omran, J., Gupta, G., Hassan, Y., Abdelaleem, R., Perez, R., Faber, S., Pietrzak, M., Webb, A., Zhang, X., Kenney, A., Bissel, D., Estfanous, S., Daily, K., Mcnamara, A., KC, M., Peeples, M., Hemann, E., Nimjee, S., Cormet-Boyaka, E., Li, J., Boyaka, P., Yount, J., Segal, B., Dubey, P., Amer, A.
10.1101/2025.11.01.684729 — Posted: 2025-11-03
Neutral Frustration Landscape Architecture of SARS-CoV-2 Spike -Antibody Interfaces Shapes Immune Evasion Mechanisms for Ultrapotent Neutralizing Antibodies and Determines Pathways of Viral Adaptation: Insights from Integrative Computational Approach
Alshahrani, M., Parikh, V., Foley, B., Verkhivker, G.
10.1101/2025.10.31.685956 — Posted: 2025-11-03
In vitro Characterization of Peptidomimetic Proteolysis Targeting Chimera (PROTAC) as a Degrader of 3-Chymotrypsin-Like Protease (Mpro/3CLpro) against SARS-CoV-2
Liturri, M. G., Bergna, A., Lai, A., Della Ventura, C., Gabrieli, A., Seravalli, I., Ciofi-Baffoni, S., Lenci, E., Trabocchi, A., Rusconi, S.
10.1101/2025.10.30.685646 — Posted: 2025-11-03
SARS-CoV-2 Variant-Dependent Alterations in Nasopharyngeal Microbiota and Host Inflammatory Response
Maulen, M., Pezoa-Soto, I., Leon, D., Dominguez, E. M., Martin, A. J., Diaz-Vasquez, W. A.
10.1101/2025.10.30.685528 — Posted: 2025-11-03
Increased Insulin Resistance and Hyperglycemia in Long COVID disease: A Systematic Review and Meta-Analysis
Almulla, A. F., Zhang, Y., Tunvirachaisakul, C., Carvalho, A. F., Maes, M.
10.1101/2025.11.01.25339290 — Posted: 2025-11-02
Preferential boosting of SARS-CoV-2 Omicron lineage-specific immune responses by monovalent XBB.1.5 vaccination
Geers, D., Aguilar-Bretones, M., Zaeck, L. M., Gill, P. A., Gonzalez-Lopez, C., Handrejk, K., Tan, N. H., den Hartog, Y., Gommers, L., Bogers, S., Mykytyn, A. Z., Sablerolles, R. S. G., Goorhuis, A., Postma, D. F., Visser, L. G., Dalm, V. A. S. H., Lafeber, M., Kootstra, N. A., van Baarle, D., Haagmans, B. L., Koopmans, M. P. G., GeurtsvanKessel, C. H., van der Kuy, P. H. M., van Nierop, G. P., van Zelm, M. C., de Vries, R. D.
10.1101/2025.10.30.25339006 — Posted: 2025-11-02
Psycho-social and behavioral trends in Type 2 Diabetes self-management amongst medically underserved patients during the COVID-19 pandemic in an mHealth intervention
Campbell, E., Jia, H., Cassells, A., Lin, T., Cortez Lainez, J., Tobin, J. N., Smaldone, A., Desai, P., Hripcsak, G., Mamykina, L.
10.1101/2025.10.28.25338894 — Posted: 2025-11-02
Refined fully automated RT-qPCR assay for simultaneous detection of SARS-CoV-2, Influenza A/B, and RSV with target optimization for improved variant resilience
Pfefferle, S., Giersch, K., Noerz, D. S., Grunwald, M., Tang, H. T., Pflueger, L. S., Luetgehetmann, M.
10.1101/2025.10.29.25339068 — Posted: 2025-10-31
Fine-tuned Protein Language Model Identifies Antigen-specific B Cell Receptors from Immune Repertoires
Paco, K., Mendivil, M. P., Zhang, Z., Zebardast, S., Davila, C., Mooney, R. M., Olatoyinbo, P., Yang, T., Bassi, S., Gonzales, V., Chen, E., Ashraf, F. B., Roman, I. C., Felix, J. R., Alam, R. M., Lay, J. A., Johal, M. S., Le Roch, K. G., Tolstorukov, I., Hernandez, J. B., da Silva, F. L. B., Lonardi, S., Sazinsky, M. H., Ray, A.
10.1101/2025.10.30.685465 — Posted: 2025-10-31
Mechanism of substrate binding by the SARS-CoV-2 NiRAN domain and modulation of its activities during replication
Uday, A., Navas, M., Sivaprasad, P. S., Bhat, U., Saikrishnan, K.
10.1101/2025.10.31.685727 — Posted: 2025-10-31

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).