Channel:  Harvard Program in Therapeutic Sciences

114 Articles

Resolving deleterious and near-neutral effects requires different pooled fitness assay designs
Limdi, A., Baym, M.
10.1101/2022.08.19.504558 — Posted: 2022-08-20
Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma
Gaglia, G., Burger, M., Ritch, C. C., Rammos, D., Dai, Y., Crossland, G. E., Tavana, S. Z., Warchol, S., Jaeger, A. M., Naranjo, S., Coy, S., Johnson, A., Krueger, R., Lin, J.-R., Pfister, H., Sorger, P. K., Jacks, T., Santagata, S.
10.1101/2022.08.11.503237 — Posted: 2022-08-13
Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data
Warchol, S., Krueger, R., Nirmal, A. J., Gaglia, G., Jessup, J., Ritch, C. C., Hoffer, J., Muhlich, J. L., Burger, M., Jacks, T. L., Santagata, S., Sorger, P. K., Pfister, H.
10.1101/2022.05.09.490039 — Posted: 2022-08-11
Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks
Lakrisenko, P., Stapor, P., Grein, S., Paszkowski, Łukasz, Pathirana, D., Fröhlich, F., Lines, G. T., Weindl, D., Hasenauer, J.
10.1101/2022.08.08.503176 — Posted: 2022-08-11
Swapped genetic code blocks viral infections and gene transfer
Nyerges, A., Vinke, S., Flynn, R., Owen, S. V., Rand, E. A., Budnik, B., Keen, E., Narasimhan, K., Marchand, J. A., Baas-Thomas, M., Liu, M., Chen, K., Chiappino-Pepe, A., Hu, F., Baym, M., Church, G. M.
10.1101/2022.07.08.499367 — Posted: 2022-07-10
Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
Mills, C. E., Subramanian, K., Hafner, M., Niepel, M., Gerosa, L., Chung, M., Victor, C., Gaudio, B., Yapp, C., Nirmal, A. J., Clark, N., Sorger, P. K.
10.1101/2021.08.27.457854 — Posted: 2022-07-08
KINOMO: A non-negative matrix factorization framework for recovering intra- and inter-tumoral heterogeneity from single-cell RNA-seq data
Tagore, S., Wang, Y., Biermann, J., Rabadan, R., Azizi, E., Izar, B.
10.1101/2022.05.02.490362 — Posted: 2022-05-04
Stitching and registering highly multiplexed whole slide images of tissues and tumors using ASHLAR
Muhlich, J. L., Chen, Y.-A., Yapp, C., Russell, D. P. W., Santagata, S., Sorger, P. K.
10.1101/2021.04.20.440625 — Posted: 2022-04-25
UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues
Yapp, C., Novikov, E., Jang, W.-D., Vallius, T., Chen, Y.-A., Cicconet, M., Maliga, Z., Jacobson, C. A., Wei, D., Santagata, S., Pfister, H., Sorger, P. K.
10.1101/2021.04.02.438285 — Posted: 2022-02-25
Fides: Reliable Trust-Region Optimization for Parameter Estimation of Ordinary Differential Equation Models
Froehlich, F., Sorger, P. K.
10.1101/2021.05.20.445065 — Posted: 2022-02-22

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