COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,159 Articles (22,703 medRxiv, 8,456 bioRxiv)

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Monkeypox Virus Clade IIb Isolate Exhibits Reduced Virulence Relative to Clade IIa Isolates in Multiple Murine Models
Trefry, S. V., Vidal-Freire, S., Awasthi, M., Ordonez, A. D., Eaton, B. P., Raney, C. N., Cregger, A. L., Gonzales, C. A., Enamorado, R. N., Martinez, N. A., Gohegan, D. S., Lackemeyer, M. G., Moulaei, T., Ziolkowska, N. E., Goebel, S. J., Palacios, G. F., Bavari, S., Nasar, F.
10.64898/2025.12.10.693532 — Posted: 2025-12-11
AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies
Yan, Q., Huang, X., Liu, B., Yao, Y., Zheng, H., Song, Y., Wu, F., He, Z., Li, S., Chen, F., Niu, C., Li, Z., Yuan, H., Lin, Y., Chen, L., Zang, N., Xiao, J., Wang, T., Chen, C., Bai, H., Li, J., Wu, M., Zhao, J., Yao, J., Yang, Y., Zhu, A., Zhao, J.
10.64898/2025.12.10.693372 — Posted: 2025-12-10
Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model
Kaiser, F. K., Gallogly, S., Mukesh, R., Ochwoto, M., Yinda, K. C., van Tol, S., Schulz, J., Hawes, K., Bulloch, B., McBain, A., Bushmaker, T., Okumura, A., Prado-Smith, J., Smith, B., Rosenke, K., Saturday, G., Munster, V.
10.64898/2025.12.09.693236 — Posted: 2025-12-09
Conserved phosphorylatable residues in motif G of positive-stranded virus RdRps regulate polymerase activity and suggest targets for drug design.
Duflos, C., Lizcano-Perret, B., Peersen, O., Herinckx, G., Alpizar, Y. A., Vertommen, D., Michiels, T.
10.64898/2025.12.08.692995 — Posted: 2025-12-09
A Secreted Subunit SARS-CoV-2 RBD-CpE Yeast Oral Vaccine Induces an Adaptive Immune Response in BALB/c Mice
Ramos, J. D., Bresnahan, C., Brysgel, T., Kozub, N., Mendoza, G., Murillo, L. C., Devanadera, M. K., Castillo, J., Castillo, D. A., Aguilar, J. P., Rimando, M., Austriaco, N.
10.64898/2025.12.08.692901 — Posted: 2025-12-08
The analysis of a large dataset of PCR-test results in the community reveals the impact of age, variants and vaccination status on SARS-CoV-2 viral dynamics
Beaulieu, M., Hoze, N., Vieillefond, V., Goetschy, T., Cosentino, G., Blanquart, F., Debarre, F., Guedj, J.
10.64898/2025.12.04.692282 — Posted: 2025-12-07
Serum IL-6 and IL-18 Responses in Pediatric COVID-19: Role of Vitamin D Status in a Cohort from Azerbaijan
Huseynova, I. Y., Hasanov, A. Q., Sultanova, N. H., Mammadova, F. M., Taghi-zada, T. G., Gafarov, I. A., Allahverdiyeva, A. B.
10.64898/2025.12.03.692155 — Posted: 2025-12-05
Systems Immunology of Long Covid: Insights from the STOP-PASC Clinical Trial
Maestri, E., Kwon, W. J., Zheng, H., Prestwood, T., Hedlin, H., Liang, J. W., McCann, H., Shaw, B., Tian, L., Jones, B., Lu, R., Wiley, G., Haraguchi, E., Wirz, O., Afaghani, J., Lam, B., Mahmood, D. F. D., Phillips, N. A., Sim, M. M. S., Wood, J. P., Heath, J. R., Boyd, S. D., Guthridge, J., Singh, U., Bonilla, H., Jagannathan, P., Utz, P., Geng, L. N., Khatri, P.
10.64898/2025.12.04.25341650 — Posted: 2025-12-05
Predictors of COVID-19 Vaccine Hesitancy and Adverse Events following COVID-19 vaccination among People on Anti-retroviral therapy in Nigeria
Etuk, V., Omonijo, O., Sanni, C., Ijioma, S., Abimiku, A., Okpokoro, E.
10.64898/2025.12.05.25341692 — Posted: 2025-12-05
Measurement of quality of stroke care with national electronic health records: a cohort during and after the COVID-19 pandemic
Farrell, J., Nolan, J., Lambert, R., Torralbo, A., Petersen, S. E., Hocaoglu, M., Tomlinson, C., Sofat, R., Huang, Q., Kontopantelis, E., James, M., Lessels, S., MacArthur, J. A. L., Wood, A., Whiteley, W., Denaxas, S., CVD-COVID-UK/COVID-IMPACT Consortium
10.64898/2025.12.03.25340732 — Posted: 2025-12-04

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).