Channel:  Francis Crick Institute

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Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase
Beale, R., Bertolin, A. P., Canal, B., Diffley, J. F., Drury, L. S., Howell, M., Milligan, J., Posse, V., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438807 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease
Armstrong, L. A., Beale, R., Bineva-Todd, G., Canal, B., Diffley, J. F., Drury, L. S., Howell, M., Kulathu, Y., Labib, K., Lim, C. T., Milligan, J., O'Reilly, N., Ozono, E., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U., Zeng, J.
10.1101/2021.04.07.438804 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease
Basier, C., Basu, S., Beale, R., Bertolin, A. P., Canal, B., Curran, J. F., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Milligan, J., Roberts, E., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438812 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease
Basier, C., Beale, R., Bineva-Todd, G., Canal, B., Curran, J. F., Deegan, T. D., Diffley, J. F., Fujisawa, R., Howell, M., Joshi, D., Labib, K., Lim, C. T., Milligan, J., Nagaraj, H., O'Reilly, N., Papageorgiou, G., Soudy, C., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U.
10.1101/2021.04.07.438806 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase
Beale, R., Bertolin, A. P., Borg, A., Canal, B., Diffley, J. F., Drury, L. S., Harvey, R., Howell, M., Hussain, S., Kjaer, S., McCauley, J., McCoy, L., Milligan, J., Posse, V., Roustan, C., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438808 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease
Beale, R., Bertolin, A. P., Canal, B., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438811 — Posted: 2021-04-08
Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization
Brown, A.-L., Wilkins, O. G., Keuss, M. J., Hill, S. E., Zanovello, M., Lee, W. C., Lee, F. C. Y., Masino, L., Qi, Y. A., Bryce-Smith, S., Bampton, A., Gatt, A., Phatnani, H., NYGC ALS Consortium, , Schiavo, G., Fisher, E. M. C., Raj, T., Secrier, M., Lashley, T., Ule, J., Buratti, E., Humphrey, J., Ward, M. E., Fratta, P.
10.1101/2021.04.02.438170 — Posted: 2021-04-04
Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma
East, P., Kelly, G., Biswas, D., Marani, M., Hancock, D. C., Creasy, T., Sachsenmeier, K., Swanton, C., de Carne Trecesson, S., Downward, J.
10.1101/2021.04.02.437896 — Posted: 2021-04-04
Biallelic mutations in cancer genomes reveal local mutational determinants
Demeulemeester, J., Dentro, S. C., Gerstung, M., Van Loo, P.
10.1101/2021.03.29.437407 — Posted: 2021-03-30
Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.
Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Ferrarese, R., Sisti, S., Clementi, N., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Marongiu, L., Facchini, F., Bottazzi, A., Fossali, T., Colombo, R., Clementi, M., Tagliabue, E., Pontiroli, A., Meloni, F., Wack, A., Mancini, N., Zanoni, I.
10.1101/2021.03.30.437173 — Posted: 2021-03-30

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