Channel:  Francis Crick Institute

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Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity reveals structural factors responsible for differences in amino acid preferences between peptide-based substrates and covalent inhibitors.
de Vries, L. E., Sanchez, M. I., Groborz, K., Kuppens, L., Poreba, M., Lehmann, C., Yuan, F., Arastu-Kapur, S., Horn, M., Mares, M., Bogyo, M., Drag, M., Deu, E.
10.1101/246124 — Posted: 2018-08-10
Target-specific precision of CRISPR-mediated genome editing
Chakrabarti, A. M., Henser-Brownhill, T., Monserrat, J., Poetsch, A. R., Luscombe, N. M., Scaffidi, P.
10.1101/387027 — Posted: 2018-08-09
Mapping the human kinome in response to DNA damage
Owusu, M., Bannauer, P., Mourikis, A., Jones, A., Ferreira da Silva, J., Caldera, M., Wiedner, M., Lardeau, C.-H., Menche, J., Kubicek, S., Ciccarelli, F., Loizou, J.
10.1101/385344 — Posted: 2018-08-06
Nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Agapova, A., Hunt, D. M., Petridis, M., Garza-Garcia, A., Sohaskey, C. D., Carvalho, L. P.
10.1101/385278 — Posted: 2018-08-05
Generative adversarial networks simulate gene expression and predict perturbations in single cells
Ghahramani, A., Watt, F. M., Luscombe, N. M.
10.1101/262501 — Posted: 2018-07-30
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Macpherson, J. A., Theisen, A., Masino, L., Fets, L., Driscoll, P. C., Encheva, V., Snijders, A. P., Martin, S. R., Kleinjung, J., Barran, P. E., Fraternali, F., Anastasiou, D.
10.1101/378133 — Posted: 2018-07-26
Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
Carvalho, L. P., Evangelopoulos, D., Prosser, G., Rodgers, A., Dagg, B., Khatri, B., Ho, M. M., Gutierrez, M., Cortes, T.
10.1101/374215 — Posted: 2018-07-23
Neutral tumor evolution?
Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A. M., Markowetz, F., Spellman, P. T., Morris, Q. D., Lingjaerde, O. C., Wedge, D. C., Van Loo, P., PCAWG Evolution and Heterogeneity Working Group
10.1101/158006 — Posted: 2018-07-23
Bcl6 promotes neurogenic conversion through transcriptional repression of multiple self-renewal-promoting extrinsic pathways.
Bonnefont, J., Tiberi, L., van den Ameele, J., Potier, D., Gaber, Z., Lin, X., Bilheu, A., Herpoel, A., Velez Bravo, F., Guillemot, F., Aerts, S., Vanderhaeghen, P.
10.1101/370999 — Posted: 2018-07-18
Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries
Zuercher, K., Ballif, M., Fenner, L., Borrell, S., Keller, P. M., Gnokoro, J., Marcy, O., Yotebieng, M., Diero, L., Carter, E. J., Rockwood, N., Wilkinson, R. J., Cox, H., Ezati, N., Abimiku, A. l. G., Collantes, J., Avihingsanon, A., Kawkitinarong, K., Reinhard, M., Hoemke, R., Huebner, R., Gagneux, S., Boettger, E. C., Egger, M., on behalf of the International Epidemiology Databases to Evaluate AIDS (IeDEA)
10.1101/370056 — Posted: 2018-07-18

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