Channel:  The Michael J. Fox Foundation

187 Articles

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinsons disease are associated with LRRC37A/2 expression in astrocytes
Bowles, K. R., Pugh, D. A., Liu, Y., Renton, A. E., Bandres-Ciga, S., Gan-Or, Z., Heutink, P., Siitonen, A., Bertelsen, S., Karch, C., Frucht, S., Kopell, B. H., Peter, I., Park, Y. J., Hoglinger, G. U., IPDGC, , Charney, A. W., Raj, T., Crary, J. F., Goate, A. M.
10.1101/860668 — Posted: 2021-09-04
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, R. K., Soliman, A., Guaitoli, G., Störmer, E., von Zweydorf, F., Dal Maso, T., Van Rillaer, L., Schmidt, S. H., Chatterjee, D., Pardon, E., Knapp, S., Kennedy, E. J., Steyaert, J., Herberg, F. W., Kortholt, A., Gloeckner, C. J., Versees, W.
10.1101/2021.08.30.458082 — Posted: 2021-08-30
LRRK2 causes centrosomal deficits via phosphorylated Rab10 and RILPL1 at centriolar subdistal appendages
Ordonez, A. J. L., Fernandez, B., Fasiczka, R., Naaldijk, Y., Fdez, E., Blanca Ramirez, M., Phan, S., Boassa, D., Hilfiker, S.
10.1101/2021.08.23.457380 — Posted: 2021-08-24
Structural basis for feedforward control in the PINK1/parkin pathway
Sauve, V., Sung, G., MacDougall, E., Kozlov, G., Saran, A., Fakih, R., Fon, E. A., Gehring, K.
10.1101/2021.08.16.456440 — Posted: 2021-08-17
Single molecule fingerprinting reveals different amplification properties of α-synuclein oligomers and preformed fibrils in seeding assay.
Lau, D., Magnan, C., Hill, K., Cooper, A., Gambin, Y., Sierecki, E.
10.1101/2021.08.09.455607 — Posted: 2021-08-09
Structure of PINK1 reveals autophosphorylation dimer and provides insights into binding to the TOM complex
Rasool, S., Veyron, S., Soya, N., Eldeeb, M., Lukacs, G., Fon, E. A., Trempe, J.-F.
10.1101/2021.08.05.455304 — Posted: 2021-08-05
Llamanade: an open-source computational pipeline for robust nanobody humanization
Sang, Z., Xiang, Y., Bahar, I., Shi, Y.
10.1101/2021.08.03.455003 — Posted: 2021-08-04
Proteome Profiling of Cerebrospinal Fluid Reveals Novel Biomarker Candidates for Parkinson's Disease
Karayel, O., Virreira Winter, S., Padmanabhan, S., Kuras, Y. I., Vu, D. T., Tuncali, I., Merchant, K., Wills, A.-M., Scherzer, C. R., Mann, M.
10.1101/2021.07.22.453322 — Posted: 2021-07-23
Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway
Gordian-Velez, W. J., Browne, K. D., Galarraga, J. H., Duda, J. E., Espana, R. A., Chen, H. I., Burdick, J. A., Cullen, D. K.
10.1101/2021.07.03.451006 — Posted: 2021-07-04
PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration
Huo, Y., Sawant, A., Tan, Y., Mahdi, A. H., Li, T., Ma, H., Bhatt, V., Yan, R., Coleman, J., Dreyfus, C. F., Guo, J. Y., Mouradian, M. M., White, E., Xia, B.
10.1101/2021.06.07.447248 — Posted: 2021-06-07

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