Channel:  The Michael J. Fox Foundation

187 Articles

Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins
Cogo, S., Tomkins, J. E., Vavouraki, N., Giusti, V., Forcellato, F., Franchin, C., Tessari, I., Arrigoni, G., Cendron, L., Manzoni, C., Civiero, L., Lewis, P. A., Greggio, E.
10.1101/2020.09.09.289009 — Posted: 2022-03-16
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease
Iovino, L., Giusti, V., Pischedda, F., Giusto, E., Plotegher, N., Marte, A., Battisti, I., Di Iacovo, A., Marku, A., Piccoli, G., Bandopadhyay, R., Perego, C., Bonifacino, T., Bonanno, G., Roseti, C., Bossi, E., Arrigoni, G., Bubacco, L., Greggio, E., Hilfiker, S., Civiero, L.
10.1101/2021.08.04.455053 — Posted: 2022-02-15
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
Stormo, A. E. D., Shavarebi, F., FitzGibbon, M., Earley, E. M., Ahrendt, H., Lum, L. S., Verschueren, E., Swaney, D. L., Skibinski, G., Ravisankar, A., van Haren, J., Davis, E. J., Johnson, J. R., Von Dollen, J., Mirescu, C., Balen, C., Porath, J., Crosio, C., Iaccarino, C., Dauer, W. T., Nichols, R. J., Wittmann, T., Cox, T. C., Finkbeiner, S., Krogan, N. J., Oakes, S. A., Hiniker, A.
10.1101/2020.10.21.336578 — Posted: 2021-11-11
Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small biaryl Fragments toward Discovery of biased D1 agonists
Li, H., Mirabel, R., Zimmerman, J., Ghiviriga, I., Phidd, D. K., Horenstein, N. M., Urs, N. M.
10.1101/2021.10.01.462758 — Posted: 2021-10-07
Specific Detection of Endogenous S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay
Arlinghaus, R., Iba, M., Masliah, E., Cookson, M. R., Landeck, N.
10.1101/2021.09.28.461511 — Posted: 2021-09-29
Two helices control the dynamic crosstalk between the catalytic domains of LRRK2
Weng, J.-H., Aoto, P. C., Lorenz, R., Wu, J., Schmidt, S. H., Manschwetus, J. T., Kaila-Sharma, P., Mathea, S., Knapp, S., Herberg, F. W., Taylor, S. S.
10.1101/2021.09.29.462278 — Posted: 2021-09-29
The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease
Kedariti, M., Frattini, E., Baden, P., Cogo, S., Civiero, L., Ziviani, E., Aureli, M., Kaganovich, A., Cookson, M. R., Stefanis, L. R., Surface, M., Deleidi, M., Di Fonzo, A., Alcalay, R. N., Rideout, H., Greggio, E., Plotegher, N.
10.1101/2021.09.27.461935 — Posted: 2021-09-28
PhosPiR: An automated phospho-proteomic pipeline in R
Hong, Y., Flinkman, D., Suomi, T., Pietila, S., James, P., Coffey, E., Elo, L. L.
10.1101/2021.09.14.460225 — Posted: 2021-09-15
Mapping of a N-terminal α-helix domain required for human PINK1 stabilisation, Serine228 autophosphorylation and activation in cells
Kakade, P., Ojha, H., Raimi, O., Shaw, A., Waddell, A., Ault, J., Burel, S., Brockmann, K., Kumar, A., Ahanger, M., Krysztofinska, E., Macartney, T., Bayliss, R., Fitzgerald, J. C., Muqit, M.
10.1101/2021.09.06.459138 — Posted: 2021-09-06
Rapid dynamic naturalistic monitoring of bradykinesia in Parkinson's disease using a wrist-worn accelerometer
Habets, J., Herff, C., Kubben, P. L., Kuijf, M. L., Temel, Y., Evers, L. J., Bloem, B., Starr, P. A., Gilron, R., Little, S. J.
10.1101/2021.09.03.458142 — Posted: 2021-09-05

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