COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,189 Articles (22,713 medRxiv, 8,476 bioRxiv)

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A Human Alveolus-on-Chip Recapitulates SARS-CoV-2-mediated Lung Injury in an Organ-relevant Context for Pre-clinical Applications
Kiener, M., De Maddalena, L. L., Roldan, N., Chouvardas, P., Froment, L., De Menna, M., Geiser, T., Stucki, J., Hobi, N., Kruithof-de Julio, M.
10.1101/2025.10.17.683096 — Posted: 2025-10-20
A cocktail of SARS-CoV-2 spike stem helix domain and receptor binding domain human monoclonal antibodies prevent the emerge of viral escape mutants
Ma, Y., Ye, C., Piepenbrink, M. S., Mahmoud, S. H., Cupic, A., Castro, E., Jackson, N., Bayoumi, M., Padron, A. S., Garcia-Sastre, A., Ippolito, G. C., Walter, M. R., Kobie, J., Martinez-Sobrido, L.
10.1101/2025.10.16.682699 — Posted: 2025-10-20
Predicting SARS-CoV-2 evolution dynamics with spatiotemporal resolution by DMS-empowered protein language model
Yang, S., Luo, X., Luo, J., Jian, F., Cao, Y.
10.1101/2025.10.17.683094 — Posted: 2025-10-20
Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans
Tortorici, M. A., Sprouse, K. R., Addetia, A., Brown, J. T., Harteloo, A., Elias-Warren, A., Chiu, H. Y., Veesler, D.
10.1101/2025.10.16.682893 — Posted: 2025-10-20
Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection
Long, X., Chen, R., Bai, R., Tian, B., Cao, Y., Chen, K., Li, F., Wang, Y., Tang, Y., Yang, Q., Ma, L., Wang, F., Zhou, M., Qiu, X., Lu, Y., Zheng, J., Zhou, P., Chen, X., Liu, Q., Wei, X., Shi, Y., Xue, Y., Zhao, J., Ji, W., Hu, L., Shang, J., Xu, T., Li, Z.
10.1101/2025.10.17.683077 — Posted: 2025-10-17
Serological evidence of SARS-CoV-2 infection in red and fallow deer in Great Britain.
O'Neill, J. V., Long, E., Tan, J., George, C., Olivier, J., Huang, C. Q., Stewart, H., Cantoni, D., Davis, C., Waeber, K., Bamford, C., Thompson, C., Temperton, N. J., Heeney, J. L., Carnell, G. W.
10.1101/2025.10.17.682775 — Posted: 2025-10-17
Genome-wide Screening Identifies Unique Host-Directed Drugs and Pro-viral Signalling Pathways for SARS-CoV-2
Khan, j. Q., Rajamanickam, K., Vizeacoumar, F. S., Balouchi, M., Zhang, Y., Elhasasna, H., Rohamare, M., Dong, H., Glover, K., Anderson-Woodsworth, T., Bhanumathy, K., Lew, J., Kumar, A., Vizeacoumar, F. J., Falzarano, D., Wilson, J. A.
10.1101/2025.10.15.682635 — Posted: 2025-10-17
A funnel approach to enable analyses of epitope-specific human CD4 T cells specific for influenza and SARS-CoV-2.
Richards, K. A., Mettelman, R. C., Trombley, K., Allen, E. K., Scott, Z. B., Joachimiak, A., Schultz-Cherry, S., Chaves, F., Thomas, P. G., Sant, A. J.
10.1101/2025.10.16.682991 — Posted: 2025-10-17
An unconventional HxD motif orchestrates coatomer-dependent coronavirus morphogenesis
Mohona, S., Shakya, A. K., Singh, S., Kearns, F. L., Jemison, K., Erramilli, S. K., Dey, D., Qing, E., Jennings, B. C., Doray, B., Kossiakoff, A. A., Amaro, R. E., Klose, T., Gallagher, T., Hasan, S. S.
10.1101/2025.10.16.682669 — Posted: 2025-10-17
Durability of DNA-LNP and mRNA-LNP Vaccine-Induced Immunity Against SARS-CoV-2 XBB.1.5
Tamming, L., Lansdell, C., Zhang, W., Duque, D., Bavananthasivam, J., Frahm, G., Pfeifle, A., Thulasi Raman, S. N., Wu, J., Gravel, C., Stalker, A., Stuible, M., Durocher, Y., Chen, W., Wang, L., Sauve, S., Tran, A., Johnston, M. J. W., Li, X.
10.1101/2025.10.15.682549 — Posted: 2025-10-15

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).