COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,225 Articles (22,733 medRxiv, 8,492 bioRxiv)

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SARS-CoV-2 Evolution in an HIV-Endemic Setting: A Genomic Epidemiology Study from Botswana
Geng, X., Barilar, I., Kesamang, M., Tumedi, K. A., Matsheka, M., Modongo, C., Minin, V., Shin, S.
10.1101/2025.11.21.25340589 — Posted: 2025-11-22
Optimal biannual COVID-19 vaccine boosting dates for those aged 65 and over
Townsend, J. P., Hassler, H., Dornburg, A.
10.1101/2025.11.20.25340687 — Posted: 2025-11-21
Changing impact of COVID-19 vaccination on COVID-19 mortality in the SARS-CoV-2 omicron variant period, 2022-2025
Liu, B., Stepien, S., Macartney, K.
10.1101/2025.11.20.25340696 — Posted: 2025-11-21
The effect of BCG vaccination on adult mortality during the COVID-19 pandemic: a meta-analysis of randomised controlled trials
Schaltz-Buchholzer, F., Curtis, N., Diacon, A. H., Giamarellos-Bourboulis, E. J., Kotsaki, A., Rosendahl Madsen, A. M., Messina, N. L., Nhamussua, L., Nielsen, S., Pittet, L. F., Silva, I., Sparrow, A., Upton, C., van Werkhoeven, C. H., Netea, M. G., Stabell Benn, C., Aaby, P.
10.1101/2025.11.19.25340570 — Posted: 2025-11-21
Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19
Kousathanas, A., Rawlik, K., Pairo-Castineira, E., Griffiths, F., Oosthuyzen, W., Clohisey Hendry, S., Malinauskas, T., Butler-Laporte, G., Arumugam, P., Begg, C., Chadeau-Hyam, M., Chan, G., Cooke, G., Donovan, S., Elgar, G., Fowler, T. A., Goddard, P., Hinds, C., Horby, P., Ling, L., Magavern, E. F., Maleady-Crowe, F., Montgomery, H., Odhams, C. A., Openshaw, P. J. M., Patch, C., Rendon, A., Salehi, S., Scott, R. H., Semple, M. G., Shankar-Hari, M., Siddiq, A., Stuckey, A., Summers, C., Todd, L., Walker, S., Walsh, T., Ward, H., Zainy, T., GenOMICC Investigators, , ISARIC4C Investigators
10.1101/2025.11.19.25340573 — Posted: 2025-11-21
Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin (GNA) affinity resin
Pesqueira Sanchez, M. A., de Necochea Campion, R., Dalhuisen, T., Fehrman, E. A., Chhabra, P. S., Kelly, J. D., Martin, J. N., Deeks, S. G., Henrich, T. J., Peluso, M. J., LaRosa, S. P.
10.1101/2025.11.21.689519 — Posted: 2025-11-21
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Kocher, K., Drost, F., Schuelein, C., Spriewald, B., Schubert, B., Schober, K.
10.1101/2025.11.19.688845 — Posted: 2025-11-21
Prediction of Long COVID and Mortality among Patients with Substance Use Disorder
Wu, J., Islam, K. M. S., Madiraju, P.
10.1101/2025.11.19.25340587 — Posted: 2025-11-20
A highly divergent cryptic SARS-CoV-2 lineage exhibits strong receptor binding and immune evasion
Feng, Z., Teo, Q. W., Ibrahim, B. A., Liu, W., Zhang, D., Mao, K. J., Shao, E. K., Gregory, D. A., Wilson, I. A., Johnson, M. C., Yuan, M., Wu, N. C.
10.1101/2025.11.18.25340485 — Posted: 2025-11-20
Omicron evolution drives increased ciliated cell tropism and dysfunction in nasal epithelia.
Parry, R., Mostafavi, H., McCallum, G., Sng, J. D. J., Joensuu, M., Short, K. R., Slonchak, A., Khromykh, A.
10.1101/2025.11.19.689397 — Posted: 2025-11-20

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).