COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,151 Articles (22,701 medRxiv, 8,450 bioRxiv)

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Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19
Kousathanas, A., Rawlik, K., Pairo-Castineira, E., Griffiths, F., Oosthuyzen, W., Clohisey Hendry, S., Malinauskas, T., Butler-Laporte, G., Arumugam, P., Begg, C., Chadeau-Hyam, M., Chan, G., Cooke, G., Donovan, S., Elgar, G., Fowler, T. A., Goddard, P., Hinds, C., Horby, P., Ling, L., Magavern, E. F., Maleady-Crowe, F., Montgomery, H., Odhams, C. A., Openshaw, P. J. M., Patch, C., Rendon, A., Salehi, S., Scott, R. H., Semple, M. G., Shankar-Hari, M., Siddiq, A., Stuckey, A., Summers, C., Todd, L., Walker, S., Walsh, T., Ward, H., Zainy, T., GenOMICC Investigators, , ISARIC4C Investigators
10.1101/2025.11.19.25340573 — Posted: 2025-11-21
Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin (GNA) affinity resin
Pesqueira Sanchez, M. A., de Necochea Campion, R., Dalhuisen, T., Fehrman, E. A., Chhabra, P. S., Kelly, J. D., Martin, J. N., Deeks, S. G., Henrich, T. J., Peluso, M. J., LaRosa, S. P.
10.1101/2025.11.21.689519 — Posted: 2025-11-21
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Kocher, K., Drost, F., Schuelein, C., Spriewald, B., Schubert, B., Schober, K.
10.1101/2025.11.19.688845 — Posted: 2025-11-21
Prediction of Long COVID and Mortality among Patients with Substance Use Disorder
Wu, J., Islam, K. M. S., Madiraju, P.
10.1101/2025.11.19.25340587 — Posted: 2025-11-20
A highly divergent cryptic SARS-CoV-2 lineage exhibits strong receptor binding and immune evasion
Feng, Z., Teo, Q. W., Ibrahim, B. A., Liu, W., Zhang, D., Mao, K. J., Shao, E. K., Gregory, D. A., Wilson, I. A., Johnson, M. C., Yuan, M., Wu, N. C.
10.1101/2025.11.18.25340485 — Posted: 2025-11-20
Omicron evolution drives increased ciliated cell tropism and dysfunction in nasal epithelia.
Parry, R., Mostafavi, H., McCallum, G., Sng, J. D. J., Joensuu, M., Short, K. R., Slonchak, A., Khromykh, A.
10.1101/2025.11.19.689397 — Posted: 2025-11-20
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice
Mignolet, M., Deroux, C., Florkin, T., Bielarz, V., De Swert, K., Halloin, N., Sprimont, L., Ladang, A., George, F., Gilloteaux, J., Abeloos, L., Van Weyenbergh, J., Jamoulle, M., Diederich, C., Gillet, N. A., Bulpa, P., Nicaise, C.
10.1101/2025.11.20.689423 — Posted: 2025-11-20
Humoral immunity induced by LP.8.1 monovalent vaccines against a broad range of SARS-CoV-2 variants including XEC, NB.1.8.1, XFG, and BA.3.2
Kaku, Y., Fujiwara, M., Uriu, K., Yo, M. S., Kawakubo, S., Ito, J., Itoh, N., Uwamino, Y., Saito, F., Satoh, H., The Genotype to Phenotype Japan (G2P-Japan) Consortium, , Sato, K.
10.1101/2025.11.18.689152 — Posted: 2025-11-20
A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation
Mou, H., Gao, B., Ye, G., Zhang, L., Saxena, D., Bu, F., Vishwakarma, J., Zhou, S., Bayona, C. R., Li, L., Getmanenko, Y., Bhandari, J., Bailey, C. C., Crynen, G. C., Kitzmiller, C. E., Li, H., Otsuka, Y., Wang, C., Batra, L., Weston, S., Frieman, M. B., Meyerholz, D. K., Scampavia, L., Spicer, T., Harris, R. S., Cameron, M., Bannister, T., Zheng, J., Farzan, M., Li, F., Choe, H.
10.1101/2025.11.19.689107 — Posted: 2025-11-20
Risk-Based Prioritization for COVID-19 Vaccination in the Post-Emergency Phase
Yechezkel, M., Faust, J., Netzer, D., Razi-Benita, T., Shmueli, E., Arbel, R., Yamin, D.
10.1101/2025.11.18.25340522 — Posted: 2025-11-19

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