COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,674 Articles (22,913 medRxiv, 8,761 bioRxiv)

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Discrimination of SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using a high-resolution melting-based assay: A pilot study
Aoki, A., Adachi, H., Mori, Y., Ito, M., Sato, K., Okuda, K., Sakakibara, T., Okamoto, Y., Jinno, H.
10.1101/2022.04.11.487970 — Posted: 2022-04-12
The SARS-CoV-2 receptor-binding domain facilitates neutrophil transepithelial migration and nanoparticle uptake in the mice airways
Bolkhovitina, E. L., Vavilova, J. D., Bogorodskiy, A. O., Zagryadskaya, Y. A., Okhrimenko, I. S., Sapozhnikov, A. M., Borshchevskiy, V. I., Shevchenko, M. A.
10.1101/2022.04.12.488042 — Posted: 2022-04-12
Broadly neutralizing antibodies target the coronavirus fusion peptide
Dacon, C., Tucker, C., Peng, L., Lee, C.-C. D., Lin, T.-H., Yuan, M., Cong, Y., Wang, L., Purser, L., Williams, J. K., Pyo, C.-W., Kosik, I., Hu, Z., Zhao, M., Mohan, D., Cooper, A., Peterson, M., Skinner, J., Dixit, S., Kollins, E., Huzella, L., Perry, D., Byrum, R., Lembirik, S., Zhang, Y., Yang, E. S., Chen, M., Leung, K., Weinberg, R. S., Pegu, A., Geraghty, D., Davidson, E., Douagi, I., Moir, S., Yewdell, J. W., Schmaljohn, C., Crompton, P. D., Holbrook, M. R., Nemazee, D., Mascola, J. R., Wilson, I. A., Tan, J.
10.1101/2022.04.11.487879 — Posted: 2022-04-12
Hierarchical Computational Modeling and Dynamic Network Analysis of Allosteric Regulation in the SARS-CoV-2 Spike Omicron Trimer Structures: Omicron Mutations Cooperate to Allosterically Control Balance of Protein Stability and Conformational Adaptability
Verkhivker, G. M., Agajanian, S., Kassab, R., Krishnan, K.
10.1101/2022.04.11.487920 — Posted: 2022-04-12
A high potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode
Huang, H., Li, S., Tao, Y., Xing, D., Xiong, H., Zhang, J., Li, L., Yang, X., Jiang, D., Luan, L., Lin, Y., Liu, X., Zheng, Q., Zhao, D., Xia, N., Liu, L.
10.1101/2022.04.11.487660 — Posted: 2022-04-12
An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity
Schmidt, N. M., Wing, P. A., Peters, R., Brown, R., Wang, H., Swadling, L., Newman, J., Thakur, N., Shionoya, K., Morgan, S. B., Hinks, T. S., Watashi, K., Bailey, D., Hansen, S. B., Maini, M. K., McKeating, J. A.
10.1101/2022.04.12.487988 — Posted: 2022-04-12
Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants
Chen, M., Pekosz, A., Villano, J., Shen, W., Zhou, R., Kulaga, H., Li, Z., Beck, S. E., Witwer, K. W., Mankowski, J., Ramanathan, M., Rowan, N., Lane, A.
10.1101/2022.04.12.487379 — Posted: 2022-04-12
From elimination to suppression: genomic epidemiology of a large Delta SARS-CoV-2 outbreak in Aotearoa New Zealand
Jelley, L., Douglas, J., Ren, X., Winter, D., McNeill, A., Huang, S., French, N., Welch, D., Hadfield, J., de Ligt, J., Geoghegan, J. L.
10.1101/2022.04.04.22273376 — Posted: 2022-04-12
Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist
Norris, E. G., Pan, X. S., Hocking, D. C.
10.1101/2022.04.11.487882 — Posted: 2022-04-11
Disrupting ACE2 Dimerization Mitigates the Infection by SARS-COV-2
Zhu, J., Su, Y., Tang, Y.
10.1101/2022.04.09.487739 — Posted: 2022-04-11

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).