COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,196 Articles (22,713 medRxiv, 8,483 bioRxiv)

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CAPTAIN: A multimodal foundation model pretrained on co-assayed single-cell RNA and protein
Ji, B.-Y., Hu, T.-T., Wang, J.-W., Liu, M.-M., Xu, L.-W., Zhang, Q.-H., Zhong, S.-Y., Qiao, L.-B., Zhang, Y., Peng, S.-L., Yu, F.-L.
10.1101/2025.07.07.663366 — Posted: 2025-07-08
BST-2 inhibits SARS-CoV-2 egress at intracellular membranes and is neutralized by ORF7a
Smith, A., Dong, X.
10.1101/2025.07.07.663519 — Posted: 2025-07-08
Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.
Aggarwal, A., Ognenovska, S., Ison, T., Fichter, C., Milogiannakis, V., Afzal, M., Ospina Stella, A., Waters, S., Esneau, C., Bartlett, N., Pöhlmann, S., Hoffmann, M., Burrell, L. M., Patel, S., Ellis, S., Wehrhahn, M., Ginn, A., Martinez, E., Churchill, M., Angelovich, T., Rawlinson, W. D., Yeang, M., Kok, J., Sintchenkov, V., Parry, R., Sng, J. D., Neely, G. G., Moreno, C. L., Loo, L., Kelleher, A. D., Brilot, F., Khromykh, A., Turville, S. G.
10.1101/2025.07.07.663433 — Posted: 2025-07-08
Shedding of mitochondrial Voltage-Dependent Anion Channel-1 (VDAC1) Reflects COVID-19 Severity and Reveals Macrophage Dysfunction
Sjogren, M., Duner, P., De Marinis, Y., Neumann, A., Leandersson, K., Rasmussen, M., Wollheim, C. B., Salehi, A.
10.1101/2025.07.07.663218 — Posted: 2025-07-08
Respiratory syncytial virus infection confers heterologous protection against SARS-CoV-2 via induction of γδ T cell-mediated trained immunity and SARS-CoV-2 reactive mucosal T cells
Adam, A., Wu, W., Jones, M. C., Hao, H., FNU, A., Samir, P., Bao, X., Wang, T.
10.1101/2025.07.02.662833 — Posted: 2025-07-07
Human pluripotent stem cell-derived bronchial airway organoids provide insights into differential innate immune and long-term responses to SARS-CoV-2 infection in healthy and COPD.
Morichon, L., SWAIN, J., Gros, N., Nasri, A., Foisset, F., Galisot, G., Racine, V., ASSOU, S., Bourdin, A., de Vos, J., MURIAUX, D.
10.1101/2025.06.30.662440 — Posted: 2025-07-02
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence
So, R. T., Lau, K. K., Zhou, Z., Poon, L. L., Peiris, M.
10.1101/2025.06.30.662263 — Posted: 2025-07-01
Exploring Dynamic Modulation of Binding, Allostery and Immune Resistance in the SARS-CoV-2 Spike Complexes with Classes of Antibodies Targeting Cryptic Binding Sites: Antibody-Specific Augmentations of Conserved Allosteric Architecture Can Influence Evolution of Viral Escape
Alshahrani, M., Parikh, V., Foley, B., Verkhivker, G.
10.1101/2025.06.28.662162 — Posted: 2025-07-01
SARS-CoV-2 spike protein amyloid fibrils impair fibrin formation and fibrinolysis
Westman, H., Hammarström, P., Nyström, S.
10.1101/2025.06.30.661938 — Posted: 2025-07-01
Back-projection improves inference from sparsely sampled genomic surveillance data
Finney, E. E., Lee, B., Ahmed, S. F., Sohail, M. S., Quadeer, A. A., McKay, M. R., Barton, J. P.
10.1101/2025.06.29.662219 — Posted: 2025-07-01

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).