COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

30,891 Articles (22,568 medRxiv, 8,323 bioRxiv)

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How the replication and transcription complex of SARS-CoV-2 functions in leader-to-body fusion
Li, X., Zhao, Q., Chang, J., Duan, G., Bei, J., Yau, T. O., Yang, J., Ruan, J., He, B., Shan, G.
10.1101/2021.02.17.431652 — Posted: 2021-02-17
Multiple Sites on SARS-CoV-2 Spike Protein are Susceptible to Proteolysis by Cathepsins B, K, L, S, and V
Bollavaram, K., Leeman, T., Kulkarni, A., Upshaw, S., Lee, M., Yang, J., Song, H., Platt, M. O.
10.1101/2021.02.17.431617 — Posted: 2021-02-17
A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features
Fatihi, S., Rathore, S., Pathak, A., Gahlot, D., Mukerji, M., Jatana, N., Thukral, L.
10.1101/2021.02.17.431625 — Posted: 2021-02-17 Discussion: Offsite
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
Yuan, M., Huang, D., Lee, C.-C. D., Wu, N. C., Jackson, A. M., Zhu, X., Liu, H., Peng, L., van Gils, M. J., Sanders, R. W., Burton, D. R., Reincke, S. M., Prüss, H., Kreye, J., Nemazee, D., Ward, A. B., Wilson, I. A.
10.1101/2021.02.16.430500 — Posted: 2021-02-17 Discussion: Onsite
SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys
Saunders, K. O., Lee, E., Parks, R., Martinez, D. R., Li, D., Chen, H., Edwards, R. J., Gobeil, S. M. C., Barr, M., Mansouri, K., Alam, S. M., Sutherland, L. L., Cai, F., Sanzone, A., Berry, M., Manne, K., Kapingidza, A. B., Azoitei, M., Tse, L. V., Scobey, T. D., Spreng, R., Rountree, R. W., DeMarco, C. T., Denny, T. N., Woods, C. W., Petzold, E. W., Oguin, T. H., Sempowski, G. D., Gagne, M., Douek, D. C., Tomai, M. A., Fox, C. B., Seder, R., Wiehe, K., Weissman, D., Pardi, N., Acharya, P., Andersen, H., Lewis, M. G., Moore, I. N., Montefiori, D. C., Baric, R. S., Haynes, B. F.
10.1101/2021.02.17.431492 — Posted: 2021-02-17
Delayed induction of type I and III interferons and nasal epithelial cell permissiveness to SARS-CoV-2
Hatton, C. F., Botting, R. A., Duenas, M. E., Haq, I. J., Verdon, B., Thompson, B. J., Stremenova Spegarova, J., Gothe, F., Stephenson, E. A., Gardner, A. I., Murphy, S., Scott, J., Garnett, J. P., Carrie, S., Hussain, R., Coxhead, J., Davey, T., Simpson, J., Haniffa, M., Hambleton, S., Brodlie, M., Ward, C., Trost, M., Reynolds, G., Duncan, C. J. A.
10.1101/2021.02.17.431591 — Posted: 2021-02-17
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation
Kang, L., He, G., Sharp, A. K., Wang, X., Brown, A. M., Michalak, P., Weger-Lucarelli, J.
10.1101/2021.02.13.431090 — Posted: 2021-02-17
A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice
Frantz, P. N., Barinov, A., Ruffie, C., Combredet, C., Najburg, V., Teeravechyan, S., Jongkaewwattana, A., Prot, M., Conquet, L., Montagutelli, X., Fernandes, P., Strick-Marchand, H., Di Santo, J., Simon-Loriere, E., Gerke, C., Tangy, F.
10.1101/2021.02.17.431630 — Posted: 2021-02-17 Discussion: Onsite
Association of CXCR6 with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulation
Dai, Y., Wang, J., Jeong, H.-H., Chen, W., Jia, P., Zhao, Z.
10.1101/2021.02.17.431554 — Posted: 2021-02-17
E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies
Wang, W. B., Liang, Y., Jin, Y. Q., Zhang, J., Su, J. G., Li, Q. M.
10.1101/2021.02.17.431566 — Posted: 2021-02-17

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).