Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1255 Articles

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS

Gautier, O., Blum, J. A., Nguyen, T. P., Klemm, S., Yamakawa, M., Sinnott-Armstrong, N., Zeng, Y., Davis, C.-H. O., Bombosch, J., Nakayama, L., Guttenplan, K. A., Chen, D., Kathira, A., Zhao, L. Y., Rexach, J. E., Greenleaf, W. E., Gitler, A. D.

10.1101/2025.08.21.671404 — Posted: 2025-08-25

A HIV-1 Gp41 Peptide-Liposome Vaccine Elicits Neutralizing Epitope-Targeted Antibody Responses in Healthy Individuals

Erdmann, N. B., Williams, W. B., Walsh, S. R., Grunenberg, N., Edlefsen, P. T., Goepfert, P. A., Cain, D. W., Cohen, K. W., Maenza, J., Mayer, K. H., Tieu, H. V., Sobieszczyk, M. E., Swann, E., Lu, H., De Rosa, S. C., Sagawa, Z., Lin, B. C., Carrol, R. E., McKee, K., Doria-Rose, N. A., Louder, M. K., Moody, M. A., Fox, C. B., Ferrari, G., Edwards, R. J., Acharya, P., Alam, S. M., Parks, R., Barr, M., Tomaras, G. D., Montefiori, D. C., Gilbert, P. B., McElrath, M. J., Corey, L., Haynes, B. F., Baden, L. R.

10.1101/2024.03.15.24304305 — Posted: 2025-08-22

OGDHL regulates tumor growth, neuroendocrine marker expression, and nucleotide abundance in prostate cancer

Bernard, M., Ruiz, A., Diaz, J., Nunley, N., Dove, R., Zhang, S., Lee, E., Heering, K., Bopardikar, S., Gallardo, A., Hashimoto, T., Agrawal, R., Smith, C., Wilde, B., Matulionis, N., Richards, H., Lee, S. C.-E. S., Sharifi, M., Lang, J., Zhao, S., Haffner, M., Shackelford, D., Boutros, P. C., Christofk, H., Goldstein, A. S.

10.1101/2025.05.28.656673 — Posted: 2025-08-22

MDS-associated SF3B1 mutations promote aberrant fate choice of hematopoietic stem cell via mis-splicing of mediator kinase module component CDK8

Bonner, E. A., Hsueh, T.-Y., Song, A., Arriaga-Gomez, E. A., Venkataraman, R., Sinha, S., Nguyen, E., Ferrell, P. B., Welner, R. S., Lu, R., Stirewalt, D. L., Doulatov, S., Lee, S. C.

10.1101/2025.08.14.670174 — Posted: 2025-08-19

Pro-inflammatory role of granzyme K producing bystander CD8+ T cells in acute myeloid leukemia

Aziez, L., Deredec, N., Boussaid, I., Shasha, C. G., Vazquez, R., Friedrich, C., Alik, A., Manasse, K., Fremont-Debaene, Z., Barthelemy, A., Catelain, C., Rameau, P., Vignon, M., Decroocq, J., Kosmider, O., Selimoglu-Buet, D., Newell, E. W., Solary, E., Delhommeau, F., Herault, O., TARTOUR, E., Birsen, R., Bouscary, D., Fontenay, M., Chapuis, N., Simoni, Y.

10.1101/2025.08.12.669682 — Posted: 2025-08-15

Multi-Ancestry Transcriptome-wide Association Studies Uncover New Insights into Breast Cancer Genetics and Biology

Ping, J., Jia, G., Cai, Q., Guo, X., Wang, J., Tao, R., Li, B., Bauer, J. A., Xie, Y., Ambs, S., Barnard, M. E., Chen, Y., Choi, J.-Y., Gao, Y.-T., Garcia-Closas, M., Gu, J., Hu, J. J., Iwasaki, M., John, E. M., Kweon, S.-S., Li, C. I., Matsuda, K., Matsuo, K., Nathanson, K. L., Nemesure, B., Olopade, O. I., Pal, T., Park, S. K., Park, B., Press, M. F., Sanderson, M., Sandler, D. P., Yao, S., Zheng, Y., Ahearn, T., Brewster, A. M., Falusi, A., Hennis, A. J., Ito, H., Kubo, M., Lee, E.-S., Makumbi, T., Mapoko, B. S., Noh, D.-Y., O'Brien, K. M., Ojengbede, O., Olshan, A. F., Park, M.-H., Reid, S

10.1101/2025.08.12.25333509 — Posted: 2025-08-13

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Elhaw, A. T., Tang, P. W., Cheng, Y.-Y., Kamlapurkar, S., Javed, Z., Al-Saad, S., White, S. R., Abdelnaby, A. E., Khan, H., Choi, A. S., Cole, A. R., Kim, Y.-S., Atiya, H. I., Trebak, M., Zervantonakis, I. K., Buckanovich, R. J., Aird, K. M., Coffman, L. G., Mythreye, K., Hempel, N.

10.1101/2025.08.12.669944 — Posted: 2025-08-13

Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer

Mout, L., Moreno-Rodriguez, T., Grillo, G., Nand, A., Keshavarzian, T., Bahl, S., Kang, K., Bootsma, M., Minnee, E., Zhou, S., Burns, K. H., Corey, E., Nelson, P., Dehm, S. M., Zhao, S. G., Zwart, W., Feng, F., Quigley, D., Lupien, M.

10.1101/2025.08.08.668693 — Posted: 2025-08-12

Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome

Boutin, T., Bretherick, A. D., Dibble, J. J., Ewaoluwagbemiga, E., Northwood, E., Samms, G. L., Vitart, V., Almelid, O., Baker, T., Clyde, M., Connolly, A., Garcia, D., Kerr, S. M., Tripp, C., Wolfe, J. C., Goold, J., Hoyes, G., Leary, S., McGrath, S. J., Milton, J., Redshaw, A., Wilson, J. M., Baxter, H., Boobyer, D., Dransfield, C., Lamirel, D., Lewis, I., Muirhead, N., Ponting, E., Shepherd, C., Turner, A., Baby, S. V., Beentjes, S., Ireland, J., Khamseh, A., McDowall, E., Perry, D., Slaughter, J., Abner, E., Boer, C. G., Estonian Biobank Research Team, , Finer, S., Genes & Health Research

10.1101/2025.08.06.25333109 — Posted: 2025-08-08

Fibrinogen-Associated Plasma Metabolites and Implications for Coagulation, Inflammation, and Vascular Diseases

Nicholas, J. C., Alkis, T., Bis, J. C., Boerwinkle, E., Brody, J. A., Clish, C. B., de Vries, P. S., Gao, Y., Gerzsten, R. E., Guo, X., Johnson, A. D., Larson, M. G., Lemaitre, R. N., Psaty, B. M., Ramachandran, V., Reiner, A. P., Rich, S. S., Rodriguez, B., Rong, J., Rotter, J. I., Simino, J., Smith, N. L., Wilson, J., Yao, J., Morrison, A. C., Yu, B., Raffield, L. M.

10.1101/2025.08.06.25333064 — Posted: 2025-08-08

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