Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1136 Articles

A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing

Paatela, E. M., St. Amant, F. G., Hamm, D. C., Bennett, S. R., Gujral, T. S., van der Maarel, S. M., Tapscott, S. J.

10.1101/2025.02.19.639175 — Posted: 2025-02-23

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

Orchard, P., Blackwell, T. W., Kachuri, L., Castaldi, P. J., Cho, M. H., Christenson, S. A., Durda, P., Gabriel, S., Hersh, C. P., Huntsman, S., Hwang, S., Joehanes, R., Johnson, M., Li, X., Lin, H., Liu, C.-T., Liu, Y., Mak, A. C. Y., Manichaikul, A. W., Paik, D., Saferali, A., Smith, J. D., Taylor, K. D., Tracy, R. P., Wang, J., Wang, M., Weinstock, J. S., Weiss, J., Wheeler, H. E., Zhou, Y., Zoellner, S., Wu, J. C., Mestroni, L., Graw, S., Taylor, M. R. G., Ortega, V. E., Johnson, C. W., Gan, W., Abecasis, G., Nickerson, D. A., Gupta, N., Ardlie, K., Woodruff, P. G., Zheng, Y., Bowler, R. P

10.1101/2025.02.19.25322561 — Posted: 2025-02-21

Multi-scale machine learning model predicts muscle and functional disease progression in FSHD

Blemker, S. S., Riem, L., DuCharme, O., Pinette, M., Costanzo, K. E., Weatherley, E., Statland, J., Tapscott, S. J., Wang, L. H., Shaw, D. W. W., The Move+ Investigator Team, , Song, X., Leung, D., Friedman, S.

10.1101/2025.02.19.639046 — Posted: 2025-02-20

3D finite element models reveal regional fatty infiltration modulates tibialis anterior force generating capacity in FSHD

McCrady, A., Friedman, S., Wang, L., Shaw, D., Tawil, R., Statland, J., Tapscott, S., Blemker, S.

10.1101/2025.02.15.25322140 — Posted: 2025-02-20

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations

Guo, B., Cai, Y., Kim, D., Smit, R. A. J., Wang, Z., Iyer, K. R., Hilliard, A. T., Haessler, J., Tao, R., Broadaway, K. A., Wang, Y., Pozdeyev, N., Staeger, F. F., Yang, C., Vanderwerff, B., Patki, A. D., Stalbow, L., Lin, M., Rafaels, N., Shortt, J., Wiley, L., Stanislawski, M., Pattee, J., Davis, L., Straub, P. S., Shuey, M. M., Cox, N. J., Lee, N. R., Jorgensen, M. E., Bjerregaard, P., Larsen, C., Hansen, T., Moltke, I., Meigs, J. B., Stram, D. O., Yin, X., Zhou, X., Chang, K.-M., Clarke, S. L., Guarischi-Sousa, R., Lankester, J., Tsao, P. S., Buyske, S., Graff, M., Raffield, L. M., Sun, Q.

10.1101/2025.02.15.25322341 — Posted: 2025-02-20

Long-Term Carotid Plaque Progression and the Role of Intraplaque Hemorrhage: Analysis from Deep Learning-based Longitudinal Vessel Wall Imaging

Guo, Y., Akcicek, E. Y., Hippe, D. S., HashemizadehKolowri, S., Wang, X., Akcicek, H., Canton, G., Balu, N., Geleri, D. B., Kim, T., Shibata, D., Zhang, K., Ma, X., Ferguson, M. S., Mossa-Basha, M., Hatsukami, T. S., Yuan, C.

10.1101/2024.12.09.24318661 — Posted: 2025-02-19

Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia

Li, R., Gagliano Taliun, S. A., Liao, K. L., Flickinger, M., Sobell, J. L., Genovese, G., Locke, A. E., Chiu, R. R., LeFaive, J., Wang, J., Martins, T. M., Chapman, S. B., Neumann, A., Handsaker, R. E., Arnett, D. K., Barnes, K. C., Boerwinkle, E., Braff, D., Cade, B. E., Fornage, M., Gibbs, R. A., Hoth, K. F., Hou, L., Kooperberg, C., Loos, R. J. F., Metcalf, G. A., Montgomery, C. G., Morrison, A. C., Qin, Z. S., Redline, S., Reiner, A. P., Rich, S. S., Rotter, J. I., Taylor, K. D., Viaud-Martinez, K. A., NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, , Genomic Psychiatry Coho

10.1101/2024.12.27.24319111 — Posted: 2025-02-19

Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis

Hart, M. L., Davidsen, K., Danquah, S., Zheng, E., Sokolov, D., Sullivan, L. B.

10.1101/2025.02.18.638948 — Posted: 2025-02-19

Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

Gray, C. N., Ashokkumar, M., Janssens, D. H., Kirchherr, J. L., Allard, B., Hsieh, E., Hafer, T. L., Archin, N. M., Browne, E. P., Emerman, M.

10.1101/2024.08.30.610517 — Posted: 2025-02-19

A Syntenic Pangenome for Gardnerella Reveals Taxonomic Boundaries and Stratification of Metabolic and Virulence Potential across Species

Bouzek, H., Srinivasan, S., Jones, D. S., McMahon, E. F., Strenk, S. M., Fiedler, T. L., Fredricks, D. N., Johnston, C. D.

10.1101/2025.02.19.636902 — Posted: 2025-02-19

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