Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1199 Articles

An Efficient Lasso Framework for Admixture-Aware Polygenic Scores

Ockerman, F. P., Chen, B. D., Sun, Q., Kharitonova, E. V., Chen, C., Zhou, L. Y., Loos, R. J., Kooperberg, C., Peters, U., Haessler, J., Reiner, A. P., Jung, S. Y., Manson, J. E., Nassir, R., North, K. E., Buyske, S., Haiman, C. A., Conti, D. V., Wilkens, L. R., Lange, E. M., Cox, N. J., Cao, H., Raffield, L. M., Li, Y., Tao, R.

10.1101/2025.08.26.671106 — Posted: 2025-08-27

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS

Gautier, O., Blum, J. A., Nguyen, T. P., Klemm, S., Yamakawa, M., Sinnott-Armstrong, N., Zeng, Y., Davis, C.-H. O., Bombosch, J., Nakayama, L., Guttenplan, K. A., Chen, D., Kathira, A., Zhao, L. Y., Rexach, J. E., Greenleaf, W. E., Gitler, A. D.

10.1101/2025.08.21.671404 — Posted: 2025-08-25

OGDHL regulates tumor growth, neuroendocrine marker expression, and nucleotide abundance in prostate cancer

Bernard, M., Ruiz, A., Diaz, J., Nunley, N., Dove, R., Zhang, S., Lee, E., Heering, K., Bopardikar, S., Gallardo, A., Hashimoto, T., Agrawal, R., Smith, C., Wilde, B., Matulionis, N., Richards, H., Lee, S. C.-E. S., Sharifi, M., Lang, J., Zhao, S., Haffner, M., Shackelford, D., Boutros, P. C., Christofk, H., Goldstein, A. S.

10.1101/2025.05.28.656673 — Posted: 2025-08-22

A HIV-1 Gp41 Peptide-Liposome Vaccine Elicits Neutralizing Epitope-Targeted Antibody Responses in Healthy Individuals

Erdmann, N. B., Williams, W. B., Walsh, S. R., Grunenberg, N., Edlefsen, P. T., Goepfert, P. A., Cain, D. W., Cohen, K. W., Maenza, J., Mayer, K. H., Tieu, H. V., Sobieszczyk, M. E., Swann, E., Lu, H., De Rosa, S. C., Sagawa, Z., Lin, B. C., Carrol, R. E., McKee, K., Doria-Rose, N. A., Louder, M. K., Moody, M. A., Fox, C. B., Ferrari, G., Edwards, R. J., Acharya, P., Alam, S. M., Parks, R., Barr, M., Tomaras, G. D., Montefiori, D. C., Gilbert, P. B., McElrath, M. J., Corey, L., Haynes, B. F., Baden, L. R.

10.1101/2024.03.15.24304305 — Posted: 2025-08-22

MDS-associated SF3B1 mutations promote aberrant fate choice of hematopoietic stem cell via mis-splicing of mediator kinase module component CDK8

Bonner, E. A., Hsueh, T.-Y., Song, A., Arriaga-Gomez, E. A., Venkataraman, R., Sinha, S., Nguyen, E., Ferrell, P. B., Welner, R. S., Lu, R., Stirewalt, D. L., Doulatov, S., Lee, S. C.

10.1101/2025.08.14.670174 — Posted: 2025-08-19

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants

Dadonaite, B., Harari, S., Larsen, B. B., Kampman, L., Harteloo, A., Elias-Warren, A., Chu, H. Y., Bloom, J. D.

10.1101/2025.08.18.671001 — Posted: 2025-08-19

Pro-inflammatory role of granzyme K producing bystander CD8+ T cells in acute myeloid leukemia

Aziez, L., Deredec, N., Boussaid, I., Shasha, C. G., Vazquez, R., Friedrich, C., Alik, A., Manasse, K., Fremont-Debaene, Z., Barthelemy, A., Catelain, C., Rameau, P., Vignon, M., Decroocq, J., Kosmider, O., Selimoglu-Buet, D., Newell, E. W., Solary, E., Delhommeau, F., Herault, O., TARTOUR, E., Birsen, R., Bouscary, D., Fontenay, M., Chapuis, N., Simoni, Y.

10.1101/2025.08.12.669682 — Posted: 2025-08-15

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Elhaw, A. T., Tang, P. W., Cheng, Y.-Y., Kamlapurkar, S., Javed, Z., Al-Saad, S., White, S. R., Abdelnaby, A. E., Khan, H., Choi, A. S., Cole, A. R., Kim, Y.-S., Atiya, H. I., Trebak, M., Zervantonakis, I. K., Buckanovich, R. J., Aird, K. M., Coffman, L. G., Mythreye, K., Hempel, N.

10.1101/2025.08.12.669944 — Posted: 2025-08-13

Multi-Ancestry Transcriptome-wide Association Studies Uncover New Insights into Breast Cancer Genetics and Biology

Ping, J., Jia, G., Cai, Q., Guo, X., Wang, J., Tao, R., Li, B., Bauer, J. A., Xie, Y., Ambs, S., Barnard, M. E., Chen, Y., Choi, J.-Y., Gao, Y.-T., Garcia-Closas, M., Gu, J., Hu, J. J., Iwasaki, M., John, E. M., Kweon, S.-S., Li, C. I., Matsuda, K., Matsuo, K., Nathanson, K. L., Nemesure, B., Olopade, O. I., Pal, T., Park, S. K., Park, B., Press, M. F., Sanderson, M., Sandler, D. P., Yao, S., Zheng, Y., Ahearn, T., Brewster, A. M., Falusi, A., Hennis, A. J., Ito, H., Kubo, M., Lee, E.-S., Makumbi, T., Mapoko, B. S., Noh, D.-Y., O'Brien, K. M., Ojengbede, O., Olshan, A. F., Park, M.-H., Reid, S

10.1101/2025.08.12.25333509 — Posted: 2025-08-13

Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer

Mout, L., Moreno-Rodriguez, T., Grillo, G., Nand, A., Keshavarzian, T., Bahl, S., Kang, K., Bootsma, M., Minnee, E., Zhou, S., Burns, K. H., Corey, E., Nelson, P., Dehm, S. M., Zhao, S. G., Zwart, W., Feng, F., Quigley, D., Lupien, M.

10.1101/2025.08.08.668693 — Posted: 2025-08-12

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