Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1288 Articles

TILseg: Automated Whole Slide-Level Spatial Scoring of Tumor-Infiltrating Lymphocytes Reveals Prognostic Patterns in Triple Negative Breast Cancer

Carr, L. L., Sankaranarayanan, A., Ha, K., Rawlani, M., Kazerouni, A. S., Specht, J., Kennedy, L. C., Reiter, D., Dintzis, S., Hippe, D. S., Kilgore, M. R., Symonds, L., Partridge, S. C., Mittal, S.

10.64898/2026.01.08.26343727 — Posted: 2026-01-21

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing

Hartweger, H., Ruprecht, C., Yao, K.-H., Laffont, P., Lima dos Reis, G., Zhou, P., Hägglöf, T., Binet, L., Loewe, M., Hong, J. P., Xiao, T., Sefik, E., Hernandez, B., Gazumyan, A., Jankovic, M., Seaman, M. S., Costa, G., Nelson, S. A., Clark, J., Kanatani, S., Wilson, P. C., Krammer, F., Levashina, E. A., Julien, J.-P., Wardemann, H., Sinnis, P., Stamatatos, L., Flavell, R. A., Nussenzweig, M. C.

10.64898/2026.01.16.699998 — Posted: 2026-01-18

Ribosome-associated quality control of aberrant protein production during amino acid limitation

Darnell, A. M., Chidley, C., Paradise, V., Cui, D. S., Davidsen, K., Lincoln, S. C., Abbott, K. L., Elbashir, R., Vander Heiden, C. P., Sorger, P. K., Sullivan, L. B., Davis, J. H., Vander Heiden, M. G.

10.64898/2026.01.14.699605 — Posted: 2026-01-15

Unifying phylogenetic traversal and deep learning to guide tree exploration

Collienne, L., Richman, H., Rich, D. H., Barker, M., Jennings-Shaffer, C., Matsen, F. A.

10.64898/2026.01.14.699358 — Posted: 2026-01-14

The temporal dynamics of the immune response to neoadjuvant androgen deprivation therapy suggests a window-of-opportunity for checkpoint inhibitor therapy in prostate cancer

Jamroze, A., Zhang, R., Ahuja, K., Deng, L., Jatwani, K., Nguyen, U., Farmer, B., James, G., Mastri, M., Eng, K. H., Xu, B., Saenger, Y. M., Yang, Y., Krolewski, J. J., Tang, D. G., Chatta, G., Nastiuk, K. L.

10.64898/2026.01.10.26343859 — Posted: 2026-01-13

Hidden Markov models detect recombination and ancestry of SARS-CoV-2

Masaki, N., Bedford, T.

10.1101/2025.11.08.687354 — Posted: 2026-01-08

Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures

Ahn, J. J., Yu, T. C., Dadonaite, B., Radford, C. E., Bloom, J. D.

10.64898/2026.01.05.697808 — Posted: 2026-01-06

Developmental programming of hematopoietic stem cell dormancy by evasion of Notch signaling

Herrero-Molinero, P., Canton, E., Maqueda, M., Ruiz-Herguido, C., Iglesias, A., Gonzalez, J., Hadland, B., Espinosa, L., Bigas, A.

10.64898/2026.01.02.697352 — Posted: 2026-01-04

Functional and antigenic constraints on the Nipah virus fusion protein

Larsen, B. B., Harari, S., Gen, R., Stewart, C., Veesler, D., Bloom, J. D.

10.1101/2025.10.15.682664 — Posted: 2026-01-01

CausalGRN: deciphering causal gene regulatory networks from single-cell CRISPR screens

Yu, B., Liu, D., Qi, G., Huangfu, D., Hsu, L., Shojaie, A., Sun, W.

10.64898/2025.12.30.692369 — Posted: 2025-12-31

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