Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1393 Articles

Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability

Brain, J. A., Chang, S. M., Kobiesa, M., Rector, L. G., Ceribelli, M., Kim, S. H., Li, Z., Do, B. T., Che, K. J., Holland, D. T., Block, S., Chang, R., Oaks, G. E., Thomas, C. J., Vander Heiden, M. G., Sullivan, L. B.

10.64898/2026.07.06.736827 — Posted: 2026-07-07

Fitness flux in SARS-CoV-2 and influenza H3N2

Bedford, T.

10.64898/2026.07.05.736619 — Posted: 2026-07-06

Complex structural variation, phylogeny, and disease associations of the mucin pangenome

Plender, E. G., Prodanov, T., Lin, J., Wong, I., Wertz, J., Gordon, W. W., Bamshad, M. J., Munson, K. M., O'Neal, W. K., Bloom, J. D., Human Pangenome Reference Consortium, , Marschall, T., Eichler, E. E.

10.64898/2026.07.01.26356476 — Posted: 2026-07-04

Priming of Multiple HIV Neutralizing B Cell Precursors in Humans

Yeh, C.-H., Walsh, S. R., Parsons, R. J., Zhang, Q. E., Thakur, B., Song, K., Liu, K., Kirshner, H. F., Van ltallie, E., Clark, M., Hahn, W. O., Song, S., Lin, L., Huang, H.-I., Lugo, J., Quan, A., Xue, Y., chen, Y., Ryan, T., Mansouri, K., Spence, T. N., Laukaitis, H. A., Parks, R., Barr, M., Schweer, E., Levering, N., Eaton, A., Shen, S., Janowska, K., Ilevbare, V., Johnson, G., Wang, P., Cain, D. W., Arus-Altuz, A., Donahue, E., Zhbannikov, I., Berry, M., Venkatayogi, S., Martin Beem, J. S., Hyrien, O., Yu, P.-C., Polakowski, L. L., Tindale, I., Yurdadon, C., Burnham, R., Andriesen, J., Wag

10.64898/2026.05.02.26352058 — Posted: 2026-06-30

Effectiveness of pharmacy-based HIV pre- and post-exposure prophylaxis delivery: a cluster-randomized trial in Kenya

Ortblad, K. F., Meisner, A., Omollo, V., Kareithi, T., Roche, S. D., Ongwen, P., Asewe, M., Anyona, M. O., Banerjee, P., Curran, K., Gichuru, E., Harkey, K., Juma, L., Kiptinness, C., Malen, R. C., Mugambi, M. L., Otieno, P., Pintye, J., Rono, B., Schaafsma, T. T., Shah, P. D., Sharma, M., Thomas, K. K., Yu, K., Were, D., Bukusi, E. A., Ngure, K.

10.64898/2026.06.26.26356703 — Posted: 2026-06-29

IntegrateRigor: annotation-free integration optimization for cell identity recovery reveals cancer-immune interface niches

Zhai, Z., Wang, C., Jiang, C., Rong, Z., Li, J. J.

10.64898/2026.05.14.725078 — Posted: 2026-06-27

The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

Shen, B. A., Asfahl, K. L., Lim, B., Bertolli, S. K., Minot, S. S., Radey, M. C., Penewit, K., Ngo, B., Salipante, S. J., Johnston, C. D., Peterson, S. B., Goodman, A. L., Mougous, J. D.

10.1101/2025.11.29.690828 — Posted: 2026-06-26

Pembrolizumab, Temozolomide and HSPPC-96 Vaccine in Newly Diagnosed Glioblastoma Post-Chemoradiation: Results from a Multi-institutional, Phase 2, Randomized, Placebo-Controlled Trial

Ozer, B. H., Lindhorst, S. M., Merrell, R. T., Trevino, C. R., Rudnick, J. D., Avgeropoulos, N. G., Ramakrishna, N., Khagi, S., Rauf, Y., Walbert, T., Pan, E., Youssef, M., Fink, K. L., Mandel, J. J., Taylor, L. P., Colman, H., Dunbar, E. M., Paleologos, N., Burton, E. C., Wu, J., Leeper, H. E., Gonzalez, J., Penas-Prado, M., Raizer, J. J., Veglia, E., Craig, S., Yuan, Y., Chambers, C., Wall, K., Grajkowska, E., Mendoza, T., Armstrong, T. S., Gilbert, M. R.

10.64898/2026.06.22.26354817 — Posted: 2026-06-24

SARS-CoV-2 saltational events are recurrent and trace to persistent human infections

Tran-Kiem, C., Kistler, K., Hisner, R., Bedford, T.

10.64898/2026.06.18.733214 — Posted: 2026-06-19

Viral load-driven systemic immune exhaustion is an enabler of antibody breadth in HIV infection

de los Rios Kobara, I., Mangalanathan, U., Deline-Caballero, S., Pinedo, K., Stabile, M., Espinosa Bernal, C. A., Itell, H. L., Chohan, V., McClelland, R. S., Mandaliya, K., Overbaugh, J., Blish, C. A.

10.64898/2026.06.05.730519 — Posted: 2026-06-17

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