Channel:  Impact of Genomic Variation on Function (IGVF)

232 Articles

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Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function
McCutcheon, S., Swartz, A., Brown, M., Barrera, A., McRoberts Amador, C., Siklenka, K., Humayun, L., Isaacs, J., Reddy, T. E., Nair, S., Antonia, S., Gersbach, C. A.
10.1101/2023.05.01.538906 — Posted: 2023-05-01
Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness
Lareau, C. A., Yin, Y., Gutierrez, J. C., Dhindsa, R. S., Gribling-Burrer, A.-S., Hsieh, Y.-H., Nitsch, L., Buquicchio, F. A., Abay, T., Zielinski, S., Stickels, R. R., Ulirsch, J. C., Yan, P., Wang, F., Miao, Z., Sandor, K., Daniel, B., Liu, V., Wang, Q., Hu, F., Smith, K. R., Deevi, S. V. V., Maschmeyer, P., Petrovski, S., Smyth, R. P., Greenleaf, W. J., Kundaje, A., Munschauer, M., Ludwig, L. S., Satpathy, A. T.
10.1101/2023.04.23.537997 — Posted: 2023-04-23
Assessing the multimodal tradeoff
Booeshaghi, A. S., Gao, F., Pachter, L.
10.1101/2021.12.08.471788 — Posted: 2023-04-18
A transient dermal niche and dual epidermal programs underlie sweat gland development
Dingwall, H. L., Tomizawa, R. R., Aharoni, A., Hu, P., Qiu, Q., Kokalari, B., Martinez, S. M., Donahue, J. C., Aldea, D., Mendoza, M., Glass, I. A., Birth Defects Research Laboratory, , Wu, H., Kamberov, Y. G.
10.1101/2023.04.15.537037 — Posted: 2023-04-17
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
Li, X., Chen, W., Martin, B. K., Calderon, D., Lee, C., Choi, J., Chardon, F. M., McDiarmid, T., Kim, H., Lalanne, J.-B., Nathans, J. F., Shendure, J.
10.1101/2023.04.12.536587 — Posted: 2023-04-12
Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models
Li, J., Jin, C., Gustafsson, S., Rao, A., Wabitsch, M., Park, C. Y., Quertermous, T., Bielczyk-Maczynska, E., Knowles, J. W.
10.1101/2023.03.27.534456 — Posted: 2023-03-29
Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements
Hu, Y., Ma, S., Kartha, V. K., Duarte, F. M., Horlbeck, M., Zhang, R., Shrestha, R., Labade, A., Kletzien, H., Meliki, A., Castillo, A., Durand, N., Mattei, E., Anderson, L. J., Tay, T., Earl, A. S., Shoresh, N., Epstein, C. B., Wagers, A., Buenrostro, J. D.
10.1101/2023.03.28.533945 — Posted: 2023-03-29
Modeling tissue co-regulation to estimate tissue-specific contributions to disease
Amariuta, T., Siewert-Rocks, K., Price, A. L.
10.1101/2022.08.25.505354 — Posted: 2023-03-26
Accurate and Efficient Estimation of Local Heritability using Summary Statistics and LD Matrix
Li, H., Mazumder, R., Lin, X.
10.1101/2023.02.08.527759 — Posted: 2023-03-22
Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions
Luo, R., Yan, J., Oh, J. W., Xi, W., Shigaki, D., Wong, W., Cho, H., Murphy, D., Cutler, R., Rosen, B. P., Pulecio, J., Yang, D., Glenn, R., Chen, T., Li, Q. V., Vierbuchen, T., Sidoli, S., Apostolou, E., Huangfu, D., Beer, M. A.
10.1101/2023.03.07.531569 — Posted: 2023-03-09

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