Channel: Washington University in St. Louis

This collection includes bioRxiv and medRxiv papers from authors at Washington University in St. Louis.

2609 Articles

Early Human Pulmonary Lesions Define a Permissive Alveolar Niche forMycobacterium tuberculosis

Teles, R. M. B., Benabdessalem, C., Perrie, J., Wei, C., West, J., de Andrade Silva, B. J., Andrade, P. R., Mansky, L., Divakar, P., Fischbacher, L., Lam, K., Ma, F., Gu, Y., Rategh, K., Pillai, A., French, S. M., Romdhane, E., Barbouche, M.-R., Klechevsky, E., Colonna, M., Steyn, A. J. C., Bensinger, S., Barber, D. L., Rammeh, S., Dulai, P. S., Bryson, B. D., Pellegrini, M., Belisle, J. T., Bloom, B. R., Modlin, R. L.

10.1101/2025.07.15.664002 — Posted: 2025-10-17

An unconventional HxD motif orchestrates coatomer-dependent coronavirus morphogenesis

Mohona, S., Shakya, A. K., Singh, S., Kearns, F. L., Jemison, K., Erramilli, S. K., Dey, D., Qing, E., Jennings, B. C., Doray, B., Kossiakoff, A. A., Amaro, R. E., Klose, T., Gallagher, T., Hasan, S. S.

10.1101/2025.10.16.682669 — Posted: 2025-10-17

Predicting future cognitive impairment in preclinical Alzheimer's disease using multimodal imaging: a multisite machine learning study

Yang, B., Earnest, T., Bilgel, M., Albert, M. S., Johnson, S. C., Davatzikos, C., Erus, G., Masters, C. L., Resnick, S. M., Miller, M. I., Bakker, A., Morris, J. C., Benzinger, T. L., Gordon, B. A., Sotiras, A., for the Alzheimer's Disease Neuroimaging Initiative, , for the Preclinical Alzheimer's Disease Consortium

10.1101/2025.10.15.25337507 — Posted: 2025-10-17

The Impact of a Western Diet with High Salt on Metabolic Outcomes in Male C57bl/6J Mice

Ponte, M., Prom, J. C., Yerrathota, S., Devkota, P., Ha, L., Morris, E. M. M., Lutkewitte, A. J.

10.1101/2025.10.17.683134 — Posted: 2025-10-17

NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease

Nazeen, S., Wang, X., Morrow, A., Strom, R., Ethier, E., Ritter, D., Henderson, A., Afroz, J., Cassa, C. S., Stitziel, N. O., Gupta, R. M., Luk, K., Studer, L., Khurana, V., Sunyaev, S. R.

10.1101/2025.01.07.631688 — Posted: 2025-10-16

CIViC MCP: Integrating Large Language Models with the Clinical Interpretations of Variants in Cancer

Schimmelpfennig, L. E., Cody, Q., McMichael, J., Coffman, A., Saliba, J., Danos, A., Kiwala, S., Wagner, A. H., Sanz-Cruzado, J., Lever, J., Griffith, M., Griffith, O. L.

10.1101/2025.10.13.682185 — Posted: 2025-10-16

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

Mukhopadhyay, M., Modgekar, R., Yang-Hood, A., Ohlemiller, K. K., Militchin, V., Xiao, M., Shen, Z., Rensing, N., Wong, M., Lee, S. J., Seal, R. P., Warchol, M. E., Maloney, S. E., Yuede, C. M., Rutherford, M. A., Pangrsic, T.

10.1101/2025.10.15.682551 — Posted: 2025-10-15

Asymmetry in hydrophobicity induces electric potential in non-charged protein condensates

Yang, L., Yu, W., Zeng, X., Dai, Y.

10.1101/2025.10.15.682625 — Posted: 2025-10-15

Prognostic and Therapeutic Implications of BRAF Mutations in Acute Myeloid Leukemia

Lee, D., Abu-Shihab, Y., Plas, K., Nicolet, D., Mrozek, K., Routbort, M. J., Patel, K. P., Walker, C. J., Buss, J., Stiff, A. R., Laganson, A., DiNardo, C. D., Daver, N. G., Kadia, T. M., Ravandi, F., Carroll, A. J., Kolitz, J. E., Powell, B. L., Blum, W. G., Baer, M. R., Marcucci, G., Uy, G. L., Stock, W., Stone, R. M., Medeiros, L. J., Byrd, J. C., Blachly, J. S., Bowman, R. L., Tyner, J., Loghavi, S., Eisfeld, A.-K., Miles, L. A.

10.1101/2025.10.14.682328 — Posted: 2025-10-15

Comprehensive benchmarking of somatic single-nucleotide variant and indel detection at ultra-low allele fractions using short- and long-read data

Ha, Y.-J. J., Maziec, D., Markowski, J., Georges, S. J., Parmalee, N. L., Berselli, M., Coorens, T. H., Dong, S., Gardiner, S., Kalra, D., Li, D., Miao, B., Musunuri, R., Xue, L., Yu, Z., Walker, K., Anderson, L., Au, N. Y., Cibulskis, C., Doddapaneni, H., Grochowski, C. M., Jensen, D. M., Lindsay, T., Loy, K., Narayan, A., Narzisi, G., Ou, J., Pham, M. M., Runnels, A. M., Stergachis, A. B., Sutherlin, L. M., Wang, T., Jin, H., Feng, W. C., Zhang, Y., Veit, A. D., Kim, C. T., Chun, H.-J. E., Ardlie, K., Fulton, R. S., Germer, S., Gibbs, R. A., Marth, G. T., Bennett, J. T., Park, P. J.

10.1101/2025.10.13.681545 — Posted: 2025-10-14

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