COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,137 Articles (22,693 medRxiv, 8,444 bioRxiv)

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De novo design of ACE2 protein decoys to neutralize SARS-CoV-2
Linsky, T. W., Vergara, R., Codina, N., Nelson, J. W., Walker, M. J., Su, W., Hsiang, T.-Y., Esser-Nobis, K., Yu, K., Hou, Y. J., Priya, T., Mitsumoto, M., Pong, A., Lau, U. Y., Mason, M. L., Chen, J., Chen, A., Berrocal, T., Peng, H., Clairmont, N. S., Castellanos, J., Lin, Y.-R., Josephson-Day, A., Baric, R. S., Walkey, C. D., Swanson, R., Blancas-Mejia, L. M., Gale, M., Yen, H.-L., Silva, D.-A.
10.1101/2020.08.03.231340 — Posted: 2020-08-03
Structure of SARS-CoV-2 2'-O-methyltransferase heterodimer with RNA Cap analog and sulfates bound reveals new strategies for structure-based inhibitor design
Rosas-Lemus, M., Minasov, G., Shuvalova, L., Inniss, N., Kiryukhina, O., Brunzelle, J., Satchell, K. J.
10.1101/2020.08.03.234716 — Posted: 2020-08-03
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Liu, H., Wu, N. C., Yuan, M., Bangaru, S., Torres, J. L., Caniels, T. G., van Schooten, J., Zhu, X., Lee, C.-C. D., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., Ward, A. B., Wilson, I. A.
10.1101/2020.08.02.233536 — Posted: 2020-08-03
SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with Rae1 and Nup98
Addetia, A., Lieberman, N. A. P., Phung, Q., Xie, H., Roychoudhury, P., Loprieno, M. A., Huang, M., Shrestha, L., Jerome, K. R., Greninger, A. L.
10.1101/2020.08.03.234559 — Posted: 2020-08-03
Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery
Cuccarese, M. F., Earnshaw, B. A., Heiser, K., Fogelson, B., Davis, C. T., McLean, P. F., Gordon, H. B., Skelly, K.-R., Weathersby, F. L., Rodic, V., Quigley, I. K., Pastuzyn, E. D., Mendivil, B. M., Lazar, N. H., Brooks, C. A., Carpenter, J., Jacobson, P., Glazier, S. W., Ford, J., Jensen, J. D., Campbell, N. D., Statnick, M. A., Low, A. S., Thomas, K. R., Carpenter, A. E., Hegde, S. S., Alfa, R. W., Victors, M. L., Haque, I. S., Chong, Y. T., Gibson, C. C.
10.1101/2020.08.02.233064 — Posted: 2020-08-03
SARS-CoV-2 genome sequences from late April in Stockholm, Sweden reveal a novel mutation in the spike protein
Soratto, T. A. T., Darban, H., Bjerkner, A., Coorens, M., Albert, J., Allander, T., Andersson, B.
10.1101/2020.08.03.233866 — Posted: 2020-08-03 Discussion: Onsite
REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters
Baum, A., Copin, R., Ajithdoss, D., Zhou, A., Lanza, K., Negron, N., Ni, M., Wei, Y., Atwal, G. S., Oyejide, A., Goez-Gazi, Y., Dutton, J., Clemmons, E., Staples, H. M., Bartley, C., Klaffke, B., Alfson, K., Gazi, M., Gonzales, O., Dick, E., Carrion, R., Pessaint, L., Porto, M., Cook, A., Brown, R., Ali, V., Greenhouse, J., Taylor, T., Andersen, H., Lewis, M. G., Stahl, N., Murphy, A. J., Yancopoulos, G. D., Kyratsous, C. A.
10.1101/2020.08.02.233320 — Posted: 2020-08-03
Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells
Zhou, L., Huntington, K., Zhang, S., Carlsen, L., So, E.-Y., Parker, C., Sahin, I., Safran, H., Kamle, S., Lee, C.-M., Lee, C.-G., Elias, J. A., Campbell, K. S., Naik, M. T., Atwood, W. J., Youssef, E., Pachter, J. A., Navaraj, A., Seyhan, A. A., Liang, O., El-Deiry, W.
10.1101/2020.08.02.230839 — Posted: 2020-08-03
Mechanism of duplex unwinding by coronavirus nsp13 helicases
Hu, X., Hao, W., Qin, B., Tian, Z., Li, Z., Hou, P., Zhao, R., Cui, S., Diao, J.
10.1101/2020.08.02.233510 — Posted: 2020-08-03
Modified SIR-model applied to covid-19, similarity solutions and projections to further development
Rebhan, E.
10.1101/2020.07.30.20165035 — Posted: 2020-08-03

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).