Channel:  Francis Crick Institute

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

925 Articles

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase
Beale, R., Bertolin, A. P., Canal, B., Diffley, J. F., Drury, L. S., Howell, M., Milligan, J., Posse, V., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438807 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease
Armstrong, L. A., Beale, R., Bineva-Todd, G., Canal, B., Diffley, J. F., Drury, L. S., Howell, M., Kulathu, Y., Labib, K., Lim, C. T., Milligan, J., O'Reilly, N., Ozono, E., Tan, K. W., Ulferts, R., Weissmann, F., Wu, M., Zeisner, T. U., Zeng, J.
10.1101/2021.04.07.438804 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease
Basier, C., Basu, S., Beale, R., Bertolin, A. P., Canal, B., Curran, J. F., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Milligan, J., Roberts, E., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438812 — Posted: 2021-04-08
Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization
Brown, A.-L., Wilkins, O. G., Keuss, M. J., Hill, S. E., Zanovello, M., Lee, W. C., Lee, F. C. Y., Masino, L., Qi, Y. A., Bryce-Smith, S., Bampton, A., Gatt, A., Phatnani, H., NYGC ALS Consortium, , Schiavo, G., Fisher, E. M. C., Raj, T., Secrier, M., Lashley, T., Ule, J., Buratti, E., Humphrey, J., Ward, M. E., Fratta, P.
10.1101/2021.04.02.438170 — Posted: 2021-04-04
Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma
East, P., Kelly, G., Biswas, D., Marani, M., Hancock, D. C., Creasy, T., Sachsenmeier, K., Swanton, C., de Carne Trecesson, S., Downward, J.
10.1101/2021.04.02.437896 — Posted: 2021-04-04
Biallelic mutations in cancer genomes reveal local mutational determinants
Demeulemeester, J., Dentro, S. C., Gerstung, M., Van Loo, P.
10.1101/2021.03.29.437407 — Posted: 2021-03-30
Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.
Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Ferrarese, R., Sisti, S., Clementi, N., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Marongiu, L., Facchini, F., Bottazzi, A., Fossali, T., Colombo, R., Clementi, M., Tagliabue, E., Pontiroli, A., Meloni, F., Wack, A., Mancini, N., Zanoni, I.
10.1101/2021.03.30.437173 — Posted: 2021-03-30
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
Mantziou, V., Baillie-Benson, P., Jaklin, M., Kustermann, S., Martinez Arias, A., Moris, N.
10.1101/2021.03.30.437698 — Posted: 2021-03-30
N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers
Lueg, G. A., Faronato, M., Gorelik, A., Goya Grocin, A., Caamano-Gutierrez, E., Falciani, F., Solari, R., Carr, R., Bell, A. S., Bartlett, E., Hutton, J. A., Llorian-Sopena, M., Chakravarty, P., Brzezicha, B., Janz, M., Garnett, M. J., Calado, D. P., Tate, E. W.
10.1101/2021.03.20.436222 — Posted: 2021-03-20
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration
Guedan, A., Donaldson, C. D., Cosnefroy, O., Taylor, I. A., Bishop, K. N.
10.1101/2021.03.18.436028 — Posted: 2021-03-18

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