Channel: University of Massachusetts Chan Medical School

This collection includes bioRxiv and medRxiv papers from authors at University of Massachusetts Chan Medical School .

1272 Articles

Identification of 30 transition fibre proteins reveals a complex and dynamic structure with essential roles in ciliogenesis

Ahmed, M., Wheeler, R. J., Tyc, J., Shafiq, S., Sunter, J., Vaughan, S.

10.1101/2023.05.29.542710 — Posted: 2023-05-29

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

Shi, F., de Fatima Silva, F., Liu, D., Patel, H. U., Xu, J., Zhang, W., Turk, C., Kruger, M., Collins, S.

10.1101/2022.10.27.514130 — Posted: 2023-05-28

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Zeng, J., Nguyen, M. A., Liu, P., Ferreira da Silva, L., Lin, L. Y., Justus, D. G., Petri, K., Clement, K., Porter, S. N., Verma, A., Neri, N. R., Rosanwo, T., Ciuculescu, M.-F., Abriss, D., Mintzer, E., Maitland, S. A., Demirci, S., Tisdale, J. F., Williams, D. A., Zhu, L. J., Pruett-Miller, S. M., Pinello, L., Joung, J. K., Pattanayak, V., Manis, J. P., Armant, M., Pellin, D., Brendel, C., Wolfe, S. A., Bauer, D. E.

10.1101/2023.05.27.542323 — Posted: 2023-05-27

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

Yamada, K., Hariharan, V. N., Caiazzi, J., Miller, R., Ferguson, C., Sapp, E., Fakih, H., Tan, Q., Yamada, N., Furgal, R., Paquette, J., Bramato, B., McHugh, N., Summer, A., Lochmann, C., Godinho, B., Hildebrand, S., Echeverria, D., Hassler, M., Alterman, J., DiFiglia, M., Aronin, N., Khvorova, A.

10.1101/2023.05.26.542506 — Posted: 2023-05-26

Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators

Schultz, A., Cheng, S.-Y., Kirchner, E., Costello, S., Miettinen, H., Chaverra, M., King, C., George, L., Zhao, X., Narasimhan, J., Weetall, M., Slaugenhaupt, S., Morini, E., Punzo, C., Lefcort, F.

10.1101/2023.05.22.541535 — Posted: 2023-05-24

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

Honeywell, M. E., Isidor, M. S., Harper, N. W., Fontana, R. E., Cruz-Gordillo, P., Porto, S. A., Fraser, C. S., Sarosiek, K. A., Guertin, D. A., Spinelli, J. B., Lee, M. J.

10.1101/2023.01.17.524444 — Posted: 2023-05-17

The ENCODE4 long-read RNA-seq collection reveals distinct classes of transcript structure diversity

Reese, F., Williams, B., Balderrama-Gutierrez, G., Wyman, D., Celik, M. H., Rebboah, E., Rezaie, N., Trout, D., Razavi-Mohseni, M., Jiang, Y., Borsari, B., Morabito, S., Liang, H. Y., McGill, C. J., Rahmanian, S., Sakr, J., Jiang, S., Zeng, W., Carvalho, K., Weimer, A. K., Dionne, L. A., McShane, A., Bedi, K., Elhajjajy, S. I., Upchurch, S., Jou, J., Youngworth, I., Gabdank, I., Sud, P., Jolanki, O., Strattan, J. S., Kagda, M. S., Snyder, M. P., Hitz, B. C., Moore, J. E., Weng, Z., Bennett, D., Reinholdt, L., Ljungman, M., Beer, M. A., Gerstein, M. B., Pachter, L., Guigo, R., Wold, B. J., Mort

10.1101/2023.05.15.540865 — Posted: 2023-05-16

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis

Wayne, C. R., Bremner, L. I., Faust, T. E., Duran-Laforet, V., Ampatey, N., Ho, S. J., Feinberg, P. A., Arvanitis, P., Ciric, B., Ruan, C., Elyaman, W., Delaney, S. L., Vargas, W. S., Swedo, S., Menon, V., Schafer, D. P., Cutforth, T., Agalliu, D.

10.1101/2023.03.10.532135 — Posted: 2023-05-09

Stimulation of immunity-linked genes by membrane disruption is linked to Golgi function and the ARF-1 GTPase

Fanelli, M. J., Welsh, C. M., Lui, D. S., Smulan, L. J., Walker, A. K.

10.1101/2021.11.16.468795 — Posted: 2023-05-09

Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in Sod1 mutant mouse model of ALS.

Dominov, J. A., Madigan, L. A., Whitt, J. P., Rademacher, K. L., Webster, K. M., Zhang, H., Banno, H. A., Tang, S., Zhang, Y., Wightman, N., Shychuck, E. M., Page, J., Weiss, A., Kelly, K., Kucukural, A. A., Brodsky, M. H., Jaworski, A., Fallon, J. R., Lipscombe, D., Brown, R. H.

10.1101/2023.05.05.539444 — Posted: 2023-05-05

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