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179 Reviews — eLife — Genomics

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The CLAMP GA-binding transcription factor regulates heat stress-induced transcriptional repression by associating with 3D loop anchors.
Aguilera, J., Duan, J., Lee, R., Ray, M., Larschan, E.
10.1101/2023.10.08.561401 — Posted: 2023-10-10 — Discussion: 2026-03-31  eLife
Single-cell multi-omic analysis reveals principles of transcription-chromatin interaction during embryogenesis
Bhardwaj, V., Griffa, A., Gaza, H. V., Zeller, P., van Oudenaarden, A.
10.1101/2024.09.23.614335 — Posted: 2024-09-24 — Discussion: 2026-03-20  eLife
Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease
Howard, C. J., Abell, N. S., Warneford-Thomson, R. R., Mahdavi, E., Su, A. L., Resnick, C., Mohammed, N., Thompson, E. M., Holzinger, E. R., Catalano, K., Hukku, A., Mintier, G. A., Wilson, S. C., Maranville, J. C., Sheth, P. R., Plenge, R. M., Kosuri, S., Dickel, D. E.
10.1101/2025.10.11.681520 — Posted: 2025-10-12 — Discussion: 2026-03-18  eLife
Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations
Inchausti, L., Bilbao, L., Campo, V. A., Garat, J., Sotelo-Silveira, J., Rinaldi, G., Howick, V. M., Duhagon, M. A., G. De Gaudenzi, J., Smircich, P.
10.1101/2025.01.14.633000 — Posted: 2025-01-16 — Discussion: 2026-03-13  eLife
Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years
Phillips, M. A., Petit, R. A., Weissman, D. B., Read, T. D.
10.1101/2025.09.14.675889 — Posted: 2025-09-15 — Discussion: 2026-02-19  eLife
Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression
Lin, J., Wen, Y., Tang, J., Zhang, X., Zhang, H., Zhu, H.
10.1101/2023.05.31.543169 — Posted: 2023-06-01 — Discussion: 2026-02-09  eLife
Acetylation of H3K115 at the nucleosome dyad is associated with fragile nucleosomes at active regulatory sites.
Sengupta, D., Friman, E. T., Illingworth, R. S., Kumar, Y., Bickmore, W. A.
10.1101/2023.11.10.566531 — Posted: 2023-11-13 — Discussion: 2026-02-06  eLife
CellCover Defines Conserved Cell Types and Temporal Progression in scRNA-seq Data across Mammalian Neocortical Development
Ji, L., Wang, A., Sonthalia, S., Naiman, D. Q., Younes, L., Colantuoni, C., Geman, D.
10.1101/2023.04.06.535943 — Posted: 2023-04-07 — Discussion: 2026-01-23  eLife
Single cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location
Cruz, J., Sun, W. Y., Verbeke, A., Hariharan, I. K.
10.1101/2024.12.10.627868 — Posted: 2024-12-12 — Discussion: 2026-01-15  eLife
Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons
Barrett, A., Varol, E., Weinreb, A., Taylor, S. R., McWhirter, R., Cros, C., Vidal, B., Basavaraju, M., Poff, A., Tipps, J. A., Majeed, M., Wang, C., Bayer, E. A., Reilly, M., Yemini, E., Sun, H., Hobert, O., Miller, D. M., Hammarlund, M.
10.1101/2022.04.05.487209 — Posted: 2025-10-20 — Discussion: 2025-12-29  eLife

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