Channel: University of California, San Diego

This collection includes bioRxiv and medRxiv papers from authors at University of California, San Diego.

5264 Articles

Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Lauderdale, K., Yan, Z., Mendiola, A. S., Zhang, Y., Mallen, D., Nambiar, P., Brady, E., Miller, S. R., Acevedo, R. M., Cabriga, B., Jiang, F., Kaliss, N., Shen, K., Shin, J., Herbert, J., Ma, K., Ryu, J. K., Agrawal, A., Schuck, R., Alzamora, M. d. P. S., Sanz-Ros, J., Cobos, I., Stavenhagen, J., Kantor, A. B., Ellisman, M. H., Akassoglou, K., Palop, J. J.

10.64898/2026.05.01.722324 — Posted: 2026-05-06

Pharmacological proximities in the GPCR family discovered using contact-informed amino-acid and binding pocket similarities

So, S. S., Ngo, T., Ilatovskiy, A. V., Finch, A. M., Riek, R. P., Abagyan, R., Smith, N. J., Kufareva, I.

10.64898/2026.05.02.720972 — Posted: 2026-05-06

The contribution of short tandem repeats to splicing variation in the human cortex

Li, Y., Margoliash, J., Goren, A., Gymrek, M.

10.64898/2026.05.04.721407 — Posted: 2026-05-06

The Birth of Influenza Immunity: High-Resolution Antibody Dynamics Driven by Maternal Antibody Waning, Vaccinations, and Infections during the first Two Years of Life

Lee, S. M., Burrell, A. R., Spranger, S., Conrey, S. C., White, B., Morrow, A. L., Payne, D. C., Staat, M. A., Einav, T.

10.64898/2026.05.04.26352413 — Posted: 2026-05-06

An APOE*4-Informed Genomic Atlas of the X Chromosome in Alzheimer's Disease

Cook, N., Zeng, Y., Yang, C., Jiang, Z., Wang, T.-C., Le Guen, Y., Cody, K., Johnson, M., Zhang, R., Merritt, V. C., Hauger, R. L., The VA Million Veteran Program, , FinnGen, , Koran, M. E., Mormino, E. C., Gordon, B., DeCasien, A., Andrews, S. J., Dumitrescu, L., Archer, D. B., Hohman, T. J., Pottier, C., Cruchaga, C., Sherva, R., Logue, M., Napolioni, V., Greicius, M. D., Belloy, M. E.

10.64898/2026.05.05.26352461 — Posted: 2026-05-06

MAP3K7 novel variants in syndromic 46,XY DSD

Le, T. N. U., Moradifard, S. M., Reyes, A. P., Ngoc Can, T. B., Gomes, A. T., Jones, M. C., Vu Chi, D., Harley, V.

10.64898/2026.05.05.26352427 — Posted: 2026-05-06

Exposome contribution to the brain metabolome: importance of body brain connection.

Karu, N., Zhao, H. N., Batra, R., Arnold, M., Krumsiek, J., David, L. C., Barupal, D., Schimmel, L., Kueider-Paisley, A., Blach, C., Borkowski, K., Dorrestein, P., Bennett, D. A., Kaddurah-Daouk, R., Alzheimer's Disease Metabolomics Consortium

10.64898/2026.05.05.26352469 — Posted: 2026-05-06

Asymmetric mitochondrial trafficking maintains network morphology by balancing perinuclear biogenesis

Winter, J., Landoni, J. C., Holt, K., Ben Nejma, S., Durmus, E. B., Kleele, T., Koslover, E. F., Manley, S.

10.64898/2025.12.08.692722 — Posted: 2026-05-05

Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment

Trimble, A. S., Kubota, C. S., Zhao, E., Ruchhoeft, M. L., Weitz, J. R., Jung, W., Peck, K. L., Ogawa, S., Ashley, E. L., Tiriac, H., Oh, T. G., Lowy, A. M., Engle, D. D., Metallo, C. M.

10.64898/2026.04.14.718544 — Posted: 2026-05-05

Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence

Dunning, J. L., Kreifeldt, M., Okhuarobo, A., Lopez, C., Varodayan, F. P., Bajo, M., Smith, R. J., Moreau, C., Krull, C., Shu, L., White, A., Macedo, G., Sidhu, H., Becker, H. C., Roberto, M., Deisseroth, K., Contet, C.

10.64898/2026.04.30.722112 — Posted: 2026-05-05

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