Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1128 Articles

Simultaneous CUT&Tag profiling of the accessible and silenced regulome in single cells

Janssens, D. H., Otto, D. J., Setty, M., Ahmad, K., Henikoff, S.

10.1101/2021.12.19.473377 — Posted: 2021-12-21

Mediator is broadly recruited to gene promoters via a Tail-independent mechanism

Warfield, L., Donczew, R., Mahendrawada, L., Hahn, S.

10.1101/2021.12.21.473728 — Posted: 2021-12-21

Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry: a Cross-Ancestry Approach

Gao, G., Zhao, F., Ahearn, T., Lunetta, K. L., Troester, M. A., Du, Z., Ogundiran, T. O., Ojengbede, O., Blot, W., Nathanson, K. L., Domchek, S. M., Nemesure, B., Hennis, A., Ambs, S., McClellan, J., Nie, M., Bertrand, K., Zirpoli, G., Yao, S., Olshan, A. F., Bensen, J. T., Bandera, E. V., Nyante, S., Conti, D. V., Press, M. F., Ingles, S. A., John, E. M., Bernstein, L., Hu, J. J., Deming-Halverson, S. L., Chanock, S. J., Ziegler, R. G., Rodriguez-Gil, J. L., Sucheston-Campbell, L. E., Sandler, D. P., Taylor, J. A., Kitahara, C. M., O'Brien, K. M., Bolla, M. K., Dennis, J., Dunning, A., Easton

10.1101/2021.12.16.21266424 — Posted: 2021-12-17

Clonal hematopoiesis is driven by aberrant activation of TCL1A

Weinstock, J. S., Gopakumar, J., Burugula, B. B., Uddin, M. M., Jahn, N., Belk, J. A., Daniel, B., Ly, N., Mack, T. M., Laurie, C. A., Broome, J. G., Taylor, K. D., Guo, X., Sinner, M. F., von Falkenhausen, A. S., Kaab, S., Shuldiner, A. R., O'Connell, J. R., Lewis, J. P., Boerwinkle, E., Barnes, K. C., Chami, N., Kenny, E. E., Loos, R. J. F., Fornage, M., Hou, L., Lloyd-Jones, D. M., Redline, S., Cade, B. E., Psaty, B. M., Bis, J. C., Brody, J. A., Silverman, E. K., Yun, J. H., Qiao, D., Palmer, N. D., Freedman, B. I., Bowden, D. W., Cho, M. H., DeMeo, D. L., Vasan, R. S., Johnson, A. D., Mat

10.1101/2021.12.10.471810 — Posted: 2021-12-13

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J., Wu, K.-H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q., Kullo, I. J., Narita, A., Takayama

10.1101/2021.12.07.470215 — Posted: 2021-12-08

Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition

Bender Ignacio, R. A., Long, J. E., Saha, A., Nguyen, F. K., Joudeh, L., Valinetz, E., Mendelsohn, S. C., Scriba, T. C., Hatherill, M., Janes, H., Chruchyard, G., Buchbinder, S., Duerr, A., Shah, J. A., Hawn, T. R.

10.1101/2021.12.08.21267470 — Posted: 2021-12-08

An antibody-escape calculator for mutations to the SARS-CoV-2 receptor-binding domain

Greaney, A. J., Starr, T. N., Bloom, J. D.

10.1101/2021.12.04.471236 — Posted: 2021-12-07

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Morales Berstein, F., the PRACTICAL consortium, , McCartney, D. L., Lu, A. T., Tsilidis, K. K., Bouras, E., Haycock, P. C., Burrows, K., Phipps, A. I., Buchanan, D. D., Cheng, I., Martin, R. M., Davey Smith, G., Relton, C., Horvath, S., Marioni, R. E., Richardson, T., Richmond, R. C.

10.1101/2021.11.29.21266984 — Posted: 2021-12-07

Macaque-human differences in SARS-CoV-2 Spike antibody response elicited by vaccination or infection

Willcox, A., Sung, K., Garrett, M. E., Galloway, J. G., OConnor, M. A., Erasmus, J. H., Logue, J. K., Hawman, D. W., Chu, H. Y., Hasenkrug, K. J., Fuller, D. H., Matsen, F. A., Overbaugh, J.

10.1101/2021.12.01.470697 — Posted: 2021-12-03

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

Mac Kain, A., Maarifi, G., Aicher, S.-M., Arhel, N., Baidaliuk, A., Munier, S., Donati, F., Vallet, T., Tran, Q. D., Hardy, A., Chazal, M., Porrot, F., Ohainle, M., Carlson-Stevermer, J., Oki, J., Holden, K., Simon-Loriere, E., Bruel, T., Schwartz, O., van der Werf, S., Jouvenet, N., Nisole, S., Vignuzzi, M., Roesch, F.

10.1101/2021.05.06.442916 — Posted: 2021-11-24

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