Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1171 Articles

Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic load

Navarro-Dominguez, B., Chang, C.-H., Brand, C., Muirhead, C., Presgraves, D., Larracuente, A. M.

10.1101/2021.12.22.473781 — Posted: 2021-12-24

Active enhancers strengthen insulation by RNA-mediated CTCF binding at TAD boundaries

Islam, Z., Saravanan, B., Walavalkar, K., Thakur, J., Farooq, U., Singh, A. K., Sabarinathan, R., Pandit, A., Henikoff, S., Notani, D.

10.1101/2021.07.13.452118 — Posted: 2021-12-24

ROKET: Associating Somatic Mutation with Clinical Outcomes through Kernel Regression and Optimal Transport

Little, P., Hsu, L., Sun, W.

10.1101/2021.12.23.474064 — Posted: 2021-12-24

Simultaneous CUT&Tag profiling of the accessible and silenced regulome in single cells

Janssens, D. H., Otto, D. J., Setty, M., Ahmad, K., Henikoff, S.

10.1101/2021.12.19.473377 — Posted: 2021-12-21

Mediator is broadly recruited to gene promoters via a Tail-independent mechanism

Warfield, L., Donczew, R., Mahendrawada, L., Hahn, S.

10.1101/2021.12.21.473728 — Posted: 2021-12-21

Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry: a Cross-Ancestry Approach

Gao, G., Zhao, F., Ahearn, T., Lunetta, K. L., Troester, M. A., Du, Z., Ogundiran, T. O., Ojengbede, O., Blot, W., Nathanson, K. L., Domchek, S. M., Nemesure, B., Hennis, A., Ambs, S., McClellan, J., Nie, M., Bertrand, K., Zirpoli, G., Yao, S., Olshan, A. F., Bensen, J. T., Bandera, E. V., Nyante, S., Conti, D. V., Press, M. F., Ingles, S. A., John, E. M., Bernstein, L., Hu, J. J., Deming-Halverson, S. L., Chanock, S. J., Ziegler, R. G., Rodriguez-Gil, J. L., Sucheston-Campbell, L. E., Sandler, D. P., Taylor, J. A., Kitahara, C. M., O'Brien, K. M., Bolla, M. K., Dennis, J., Dunning, A., Easton

10.1101/2021.12.16.21266424 — Posted: 2021-12-17

Clonal hematopoiesis is driven by aberrant activation of TCL1A

Weinstock, J. S., Gopakumar, J., Burugula, B. B., Uddin, M. M., Jahn, N., Belk, J. A., Daniel, B., Ly, N., Mack, T. M., Laurie, C. A., Broome, J. G., Taylor, K. D., Guo, X., Sinner, M. F., von Falkenhausen, A. S., Kaab, S., Shuldiner, A. R., O'Connell, J. R., Lewis, J. P., Boerwinkle, E., Barnes, K. C., Chami, N., Kenny, E. E., Loos, R. J. F., Fornage, M., Hou, L., Lloyd-Jones, D. M., Redline, S., Cade, B. E., Psaty, B. M., Bis, J. C., Brody, J. A., Silverman, E. K., Yun, J. H., Qiao, D., Palmer, N. D., Freedman, B. I., Bowden, D. W., Cho, M. H., DeMeo, D. L., Vasan, R. S., Johnson, A. D., Mat

10.1101/2021.12.10.471810 — Posted: 2021-12-13

Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition

Bender Ignacio, R. A., Long, J. E., Saha, A., Nguyen, F. K., Joudeh, L., Valinetz, E., Mendelsohn, S. C., Scriba, T. C., Hatherill, M., Janes, H., Chruchyard, G., Buchbinder, S., Duerr, A., Shah, J. A., Hawn, T. R.

10.1101/2021.12.08.21267470 — Posted: 2021-12-08

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J., Wu, K.-H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q., Kullo, I. J., Narita, A., Takayama

10.1101/2021.12.07.470215 — Posted: 2021-12-08

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Morales Berstein, F., the PRACTICAL consortium, , McCartney, D. L., Lu, A. T., Tsilidis, K. K., Bouras, E., Haycock, P. C., Burrows, K., Phipps, A. I., Buchanan, D. D., Cheng, I., Martin, R. M., Davey Smith, G., Relton, C., Horvath, S., Marioni, R. E., Richardson, T., Richmond, R. C.

10.1101/2021.11.29.21266984 — Posted: 2021-12-07

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