Channel: Washington University in St. Louis

This collection includes bioRxiv and medRxiv papers from authors at Washington University in St. Louis.

3065 Articles

The orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport

Lauritsen, L., Pauli, A. T., Larsen, M. P. W., Reinholdt, P., Scheidt, H. A., Xu, Y., Covey, D. F., Depta, L., Bryce-Rogers, H. P., Laraia, L., Kongsted, J., Wüstner, D.

10.64898/2026.02.02.703222 — Posted: 2026-02-04

Single-Cell Proteomics of Human Peripheral Blood Mononuclear Cells Exceeding 600 Cells per Day

Fulcher, J. M., Kwon, Y., Dawar, P., Kumar, R., Williams, S. M., Miller, P., Liyu, A., Chen, L., Orton, D. J., Olson, H. M., Yu, F., Nesvizhskii, A. I., Fortier, J., Vij, R., Jayasinghe, R., Ding, L., Zhu, Y., Pasa-Tolic, L.

10.64898/2026.02.01.703169 — Posted: 2026-02-03

CSF turnover reshapes biomarker interpretation in neurodegeneration studies

Garcia-Gonzalez, P., Puerta, R., Dehairs, J., Yang, C., Wang, C., Timsina, J., de Rojas, I., Olive, C., Valenzuela, A., Bayon-Bujan, P., Rovira, M., Montrreal, L., Capdevila, M., Munoz-Morales, A., Calm, B., Valero, S., Alegret, M., Marquie, M., The Global Neurodegeneration Proteomics Consortium (GNPC), , Morris, J. C., Schindler, S. E., Holtzman, D. M., Sanz, P., Tarraga, L., Khan, A., Saez, M. E., Smets, B., Orellana, A., Montalban, X., Boada, M., Cano, A., Liu, M., Ali, M., Cruchaga, C., Swinnen, J. V., Fernandez, V., Cabrera-Socorro, A., Ruiz, A.

10.64898/2026.02.02.26345363 — Posted: 2026-02-03

Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain

Xie, Y., Chang, L., Zhong, G., Rink, J. A., Baez-Becerra, T., Armand, E., Ding, W., Li, K., Boone, E., Lie, A., Indralingam, H. S., Dong, K., Loe, T., Huang, B., Wang, Z., Barcoma, A. S., Willier, J. K., Knutson, K. W., Liu, J., Cho, S., Cao, S., Russo, K. G., Young, C. K., Arzavala, J., Sanchez, Y., Bikkina, A., Schenker-Ahmed, N., Kern, C., Zhao, Z., Klein, A., Flores, J., Tai, C.-Y., Olness, J., Monell, A., Moghadami, S., Barragan, C., Chen, C., Owens, W., OConnor, C., Liem, M., Marrin, M. V., Rose, C., Alt, S. N., Emerson, N., Osteen, J., Lucero, J., Li, D., Hodge, R. D., Wang, T., Keene

10.64898/2026.02.02.703166 — Posted: 2026-02-03

An immune-poised state of human bronchial epithelial cells mediates RSV resistance in adults

Zhao, C., Bai, Y., Mou, H., Lerou, P. H., Leung, D. W., Narasimhan, H., Wei, X., Sun, J., Xu, J.-F., Fearns, R., Ai, X.

10.64898/2026.02.02.703395 — Posted: 2026-02-03

Crystalline guanine packed within vacuoles serves as nitrogen store in Chromera velia

Gonepogu, V. G., Pilatova, J., Ennaceur, D., Tomcala, A., Vancova, M., Richtova, J., Roth, R., Goodenough, U., Obornik, M., Mojzes, P., Gruber, A.

10.64898/2026.01.31.703024 — Posted: 2026-02-03

Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies

Lehman, S. J., Meller, A., Solieva, S. O., Lotthammer, J. M., Greenberg, L., Langer, S. J., Greenberg, M. J., Tardiff, J. C., Bowman, G. R., Leinwand, L. A.

10.1101/2023.07.03.547580 — Posted: 2026-02-03

Quantifying biomarker ambiguity using metabolic network analysis

Hinkston, M. A., Bradley, A. S.

10.64898/2026.01.29.702649 — Posted: 2026-02-02

cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy

Huang, Y., Fan, L., Wong, M. Y., Lei, Z., Krishnamachary, B., Zhu, D., Cadiz, M., Nagiri, R. K., Ye, P., Norman, K., Bhagwat, M., Lee, Y. J., Li, H., Zhu, J., Amin, S., Lauderdale, K., Chen, H., Luo, W., Gong, S., Liechty, B. L., Palop, J. J., Sinha, S. C., Wu, J., Zhao, M., Gan, L.

10.64898/2026.01.30.702860 — Posted: 2026-02-02

An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia

Zhang, W., Ding, W., Li, K., Chang, L., Klein, A., Baez-Becerra, C. T., Rink, J. A., Bartlett, A., Chen, H., Schenker, N., Johansen, N., Mollenkopf, T., Fu, Y., Yang, X., Liu, S., Seng, C., Miao, B., Liu, T., Zhu, Q., Hodge, R. D., Bakken, T. E., Lein, E. S., Hawrylycz, M., Xu, X., Behrens, M. M., Ren, B., Ecker, J. R., Wang, T., Li, D.

10.64898/2026.01.29.702575 — Posted: 2026-02-02

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