Channel: Washington University in St. Louis

This collection includes bioRxiv and medRxiv papers from authors at Washington University in St. Louis.

3079 Articles

Resolving inflammatory bowel disease risk variants to genes and cell types

Fachal, L., Zhang, R., Gettler, K., Haritunians, T., Cleynen, I., Stevens, C. R., Tastad, C., Medici, C., Do, R., IIBDGC GWAS Group, , Abreu, M. T., Achkarj, J.-P., Ahmad, T., Bel Kok, K., Bernstein, C., Brooks, J., Bujanda, L., Butterworth, J., Clark, K., Cummings, F., D'Amato, M., Del Buono, J., Duerr, R. H., Ellinghaus, D., Foley, S., Franchimont, D., Franke, A., Hancock, L., Hart, A., Hooper, P., Irving, P., Jarvis, M., Johnston, E., Julia, A., Kemp, C., Kennedy, N., Kupcinskas, J., Latiano, A., Lewis, J., Li, A., Limdi, J., Louis, E., McLaughlin, J., Moayyedi, P., Moran, G., Mowat, C., N

10.64898/2026.05.13.26352926 — Posted: 2026-05-23

Interpreting Omics Data Analysis with Large Language Models for Disease Target and Drug Discovery

XU, Z., Chen, W., Ren, W., Xu, T., Amaechin, S., Khan, R., Chen, Y., Province, M., Payne, P., Li, F.

10.64898/2026.04.30.721768 — Posted: 2026-05-23

Transitory enhancement of GATA2 chromatin engagement during early erythroid differentiation

Hobbs, J. W., Taylor, S. J., Kumari, R., Haque, N., Victor, L., Steidl, U., Coleman, R. A.

10.64898/2026.03.05.709895 — Posted: 2026-05-23

How many genes can CRISPR edit to engineer complex adaptations?

Kyung, J., Esfahanian, M., Mann, J., Koke, E., Pham, K., Peng, Y., Exposito-Alonso, M.

10.64898/2026.05.21.726991 — Posted: 2026-05-23

Distribution of big tau isoforms in the human central and peripheral nervous system

Koppitsetti, R. K., Barthelemy, N. R., Horie, K., Ly, C. V., Roberts, K. R., Koutarapu, S., Perrin, R. J., Franklin, E. E., Pedicone, C., Orrick, J., Melendez, J., Miller, T. M., Sato, C., Ghoshal, N., Goate, A. M., Karch, C., Bateman, R. J., Mukherjee, S.

10.1101/2025.09.15.676127 — Posted: 2026-05-23

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning

Patterson, C., Chattopadhyay, T., Thomopoulos, S. I., Saykin, A., Davatzikos, C., Mormino, E., Tosun, D., Beecham, G. W., Biber, S. A., Kukull, W. A., Risacher, S. L., Montine, T. J., Johnson, S. C., Shen, L., Huang, H., Erus, G., Jun, G., Mukherjee, S., Crane, P., Cuccaro, M. L., Archer, D. B., Landman, B. A., Toga, A. W., Hohman, T. J., Thompson, P.

10.64898/2026.05.20.726332 — Posted: 2026-05-23

Widespread use of invalid statistical tests in biomedical machine learning

Zeng, T., Li, H., Zhang, S., Tan, Y. Q., Tian, F., Orban, C., An, L., Che, W., Cheng, J., Chong, J. S. X., Dehestani, N., Dong, Z., Li, X., Li, Z., Lim, M. J. R., Lin, Y., Ling, Q., Ling, Z., Low, X. Z., Mansour L., S., Ng, K. K., Nguyen, T. T., Ooi, L. Q. R., Pande, S., Qian, X., Ruan, J., Wang, Z., Xie, Y., Zhang, C., Zhang, Y., Patil, K., Parkes, L., Dhamala, E., Chopra, S., Zalesky, A., Holmes, A., Eickhoff, S., Zhou, J. H., Renaud, O., Dosenbach, N., Kording, K. P., Bzdok, D., Nichols, T., Yeo, B. T. T.

10.64898/2026.05.17.724301 — Posted: 2026-05-22

Lactational transfer of synthetic oxytocin and sex-specific suppression of neurodevelopmental risk gene networks in the rat prefrontal cortex

Serce, G., Giri, T., Son, M., Wang, R., Laury, M., George, R., McCullough, K., Maloney, S. E., Tycksen, E., Goo, Y. A., Palanisamy, A.

10.64898/2026.05.19.726042 — Posted: 2026-05-22

Impact of GLP-1 Receptor Agonists on Chronic Low Back Pain in Patients with Obesity: A Prospective Pilot Cohort Study

Benedict, B., White-Gilliam, D., Pradhan, A., Yakdan, S., Hammo, A., Budd, L., Arkam, F., Tang, S. Y., Schechtman, K. B., Cheng, A. L., Robinson Reeds, S., Goodin, B. R., Greenberg, J. K.

10.64898/2026.05.20.26353666 — Posted: 2026-05-22

Clinical course and outcomes of antibody-mediated rejection after heart transplant in the contemporary era

Yang, B. Q., Elesawy, M., Laux, S., Deych, E., Fernandes, A., Pattanayak, V., Wong, K. E., Tsao, L., Zlotoff, D. A., Kreso, A., Schilling, J. D., Lewis, G. D.

10.64898/2026.05.19.26353576 — Posted: 2026-05-21

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