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The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers
Koulle, A., Ogundele, O., Shah, D., Baker, I., Lopez, M., Reynolds, N., Ragheb, R., Laue, E. D., Hendrich, B.
10.1101/2025.08.29.672645 — Posted: 2025-08-29 — Discussion: 2026-01-19  eLife
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching
Zhang, K., Grant, T., Grigorieff, N.
10.1101/2025.09.11.675606 — Posted: 2025-09-16 — Discussion: 2026-01-19  eLife
Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles
Liu, G., Tian, Y., Hanson, M. A., Li, J., Lemaitre, B.
10.1101/2025.08.20.671119 — Posted: 2025-08-24 — Discussion: 2026-01-17  Review Commons
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
Huang, Z., Luo, S., Wang, Z., Zhang, Z., Jiang, B., Nie, Q., Zhang, J.
10.1101/2024.07.10.602845 — Posted: 2024-07-12 — Discussion: 2026-01-16  eLife
Mechanistic genotype-phenotype translation using hierarchical transformers
Lee, I., Wallace, Z., Park, S., Nam, H., Majithia, A., Ideker, T.
10.1101/2024.10.23.619940 — Posted: 2024-10-24 — Discussion: 2026-01-16  Review Commons
Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease
Graff, M. F. E., Heeg, E. E., Childs, S. J.
10.1101/2025.03.13.643043 — Posted: 2025-03-13 — Discussion: 2026-01-16  eLife
Glycolysis-dependent Sulfur Metabolism Orchestrates Morphological Plasticity and Virulence in Fungi
Shah, D., M, A., Rewatkar, N., Gupta, S., Mathivathanan, S., Varahan, S.
10.1101/2025.05.14.654021 — Posted: 2025-05-14 — Discussion: 2026-01-16  eLife
RB dependent transcriptional regulation at mitotic centromeres preserves genome stability
Manning, A. L., Crowley, E. A.
10.1101/2025.06.04.657825 — Posted: 2025-06-05 — Discussion: 2026-01-16  EMBO Press
Dual-feature selectivity enables bidirectional coding in visual cortical neurons
Franke, K., Karantzas, N., Willeke, K., Diamantaki, M., Ramakrishnan, K., Elumalai, P., Restivo, K., Fahey, P., Nealley, C., Shinn, T., Garcia, G., Patel, S., Ecker, A., Walker, E. Y., Froudarakis, E., Sanborn, S., Sinz, F. H., Tolias, A.
10.1101/2025.07.16.665209 — Posted: 2025-07-21 — Discussion: 2026-01-16  eLife
Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning
Wang, G., Zhou, N., Leveroni, Z. M., Yu, J.
10.1101/2025.08.11.669642 — Posted: 2025-08-11 — Discussion: 2026-01-16  eLife

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