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Omics-based insights into human liver reveal GTPase-driven mechanisms of MASLD progression in obesity
Zhao, Q., de Nardo, W., Wang, R., Zhong, Y., Keles, U., Zhao, L. N., Tay, H., Youhanna, S., Yan, M., Xie, Y., Kim, Y., Lee, S., Lim, R. L., Teo, G., Naraya, P., Burton, P. R., Lauschke, V. M., Choi, H., Watt, M. J., Kaldis, P.
10.1101/2025.01.13.632747 — Posted: 2025-01-14 — Discussion: 2026-02-23  eLife
Mapping regulatory networks underlying Leishmania stage differentiation reveals an essential role for protein degradation in parasite development
Pescher, P., Douche, T., Giai Gianetto, Q., Druart, K., Kovarova, J., Li, B., Proux, C., Legendre, R., Varet, H., Rajan, K. S., Piel, L., Besse, C., Boland, A., Deleuze, J.-F., Matondo, M., Barrett, M. P., Michaeli, S., Späth, G. F.
10.1101/2025.03.24.644963 — Posted: 2025-03-28 — Discussion: 2026-02-23  Review Commons
A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival
Chen, L., Duan, B., Chen, P., Jiang, Q., Wang, Y., Lu, L., Chen, Y., Hu, C., Zhang, L., Guo, A.
10.1101/2025.05.21.655295 — Posted: 2025-05-21 — Discussion: 2026-02-23  eLife
Tau hyperphosphorylation impairs cooperative binding tomicrotubules and perturbs organelle trafficking in neurons
Beaudet, D., Berger, C. L., Hendricks, A. G.
10.1101/2025.07.31.667882 — Posted: 2025-07-31 — Discussion: 2026-02-23  eLife
Earliest Evidence of Elephant Butchery at Olduvai Gorge (Tanzania) Reveals the Evolutionary Impact of Early Human Megafaunal Exploitation
Dominguez-Rodrigo, M., Baquedano, E., Moclan, A., Uribelarrea, D., Velazquez-tello, A., Corre-Cano, J. A., Diez-Martin, F., Organista, E., Mendez-Quintas, E., Vegara-Riquelme, M., Gidna, A., Mabulla, A.
10.1101/2025.08.28.672811 — Posted: 2025-08-28 — Discussion: 2026-02-23  eLife
Ventral Hippocampal Temporoammonic and Schaffer Collateral Pathways Differentially Control Fear- and Anxiety-Related Behaviors
Kambali, M., Wang, M., Nagarajan, R., Lyu, J., Gritton, H., Rudolph, U.
10.1101/2025.11.26.690696 — Posted: 2025-11-26 — Discussion: 2026-02-23  eLife
Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation
de Carvalho, R. S. A., Rasel, M. S. I., Khandelwal, N. K., Tomasiak, T. M.
10.1101/2024.03.06.583773 — Posted: 2024-03-06 — Discussion: 2026-02-20  EMBO Press
Leiomodin 1 promotes myogenic differentiation by modulating Sirtuin 1
Spath, E., Schuler, S. C., Heinze, I., Dau, T. T. D., Minetti, A., Hofmann, M., von Maltzahn, J., Ori, A.
10.1101/2024.03.29.587321 — Posted: 2024-03-29 — Discussion: 2026-02-20  eLife
The insulin / IGF axis is critically important controlling gene transcription in the podocyte.
Hurcombe, J. A., Dayalan, L., Barrington, F., Burdet, F., Ni, L., Coward, J. T., Brinkkoetter, P., Holzenberger, M., Jeffries, A. R., Oltean, S., Welsh, G. I., Coward, R. J.
10.1101/2024.05.20.594973 — Posted: 2024-05-21 — Discussion: 2026-02-20  eLife
Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration
Beirowski, B., Huang, H., Babetto, E.
10.1101/2025.07.21.665928 — Posted: 2025-07-22 — Discussion: 2026-02-20  eLife

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