Channel:  Aligning Science Across Parkinson's (ASAP)

531 Articles

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Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson's disease: LRRK2-driven systemic depletion of pyrimidine nucleosides
Ma, Y., Erb, M. L., Sipple, K. A., Offerman, A. V., Niu, J., Madaj, Z. B., Fu, Z., Lau, K. H., Moore, D. J.
10.64898/2025.12.31.697225 — Posted: 2026-05-12
Para-subthalamic nucleus adjoins subthalamic nucleus and medial forebrain bundle, major DBS-targets in Parkinsons disease, OCD, and depression
Dumas, S., Francois, C., Biviano Rosenkilde, M., Roostalu, U., Karachi, C., Wallen-Mackenzie, A.
10.1101/2025.05.21.655268 — Posted: 2026-05-11
A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical and dopaminergic-like induced neurons
Kraus, F., He, Y., Jiang, Y., Li, D., Ambaw, Y. A., Gasparoli, F. M., Paulo, J. A., Walther, T. C., Farese, R., Gygi, S. P., Wilfling, F., Harper, J. W.
10.1101/2025.10.08.681047 — Posted: 2026-05-10
An isogenic single-cell atlas of familial Parkinson's disease mutations reveals convergent changes in dopamine neurons
Syed, K. M., Dunnack, J., Paatz, S., Ajjarapu, K., Sahagun, A., Rio, D., Soldner, F., Bateup, H., Hockemeyer, D.
10.64898/2026.05.04.722458 — Posted: 2026-05-10
Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease
Sah, S., Sauerbeck, A. D., Gupta, J., Perez-Acuna, D., Reiber, J. E., Russell, D., Goralski, T., Henderson, M., Volpicelli-Daley, L. A., Higley, M. J., Kummer, T. T., Biederer, T.
10.1101/2024.06.20.599774 — Posted: 2026-05-08
Utilizing Intraindividual Cognitive Variability to Predict Stage 2 Neuronal Synuclein Disease Progression
Combs, H. L., Kurth, R., Nair, A., York, M. K., Weintraub, D., Lafontant, D.-E., Caspell-Garcia, C., and the Parkinson's Progression Markers Initiative
10.1101/2025.10.21.25338482 — Posted: 2026-05-01
A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention
Marciano, S., Velazquez, L. G., Rodriguez Lopez, C., De Silva, N., Sommer, G., Tower, W., Torrres, E. R. S., Kaplitt, M. G., Milner, T. A., Marongiu, R.
10.64898/2026.03.20.712963 — Posted: 2026-04-30
Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease
Lin, Z., Parker, J., Nithianandam, V., Mathivanan, S., Wang, T., Liao, Z., Simmons, S. K., Tuncali, I., Adiconis, X., Haywood, N., Weykopf, B., Teng, X., Sharma, M., Yuan, J., Baecher-Allan, C., Dong, X., Beach, T. G., Serrano, G. E., Levin, J. Z., Zhang, S., Feany, M. B., Scherzer, C. R.
10.64898/2026.04.24.720642 — Posted: 2026-04-29
Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
Simmons, D. V., Moreno-Ramos, O. A., Raj, D. D. A., Kaganovsky, K., Pamukcu, A., Vrieler, N., Tkatch, T., Xie, Z., Zampese, E., De Sousa, A. I. S., Ding, J., Awatramani, R. V., Wilson, C., Surmeier, D. J.
10.1101/2024.03.27.586699 — Posted: 2026-04-17
LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death
Goldman, A., Nguyen, M., Lanoix, J., Li, C., Fahmy, A., Zhong Xu, Y., Schurr, E., Thibault, P., Desjardins, M., McBride, H.
10.1101/2025.08.25.672135 — Posted: 2026-04-17

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