Channel:  Aligning Science Across Parkinson's (ASAP)

476 Articles

Alternative Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration
Fernandez-Suarez, M. E., Bush, R., Brenton, J. W., Pereira, G., Grant-Peters, M., Reynolds, R. H., te Vruchte, D., Shepherd, D., Weng, Y., Artaza-Fernandez, E., Lis, P., Sanchez-Pulido, L., Morgan, A., Davis, L., Gomez-Coronado, D., Eden, E. R., Alessi, D. R., Ponting, C., Galione, A., Newstead, S., Hardy, J., Patel, S., Ryten, M., Platt, F. M.
10.1101/2025.10.01.679724 — Posted: 2026-02-11
High-frequency axonal bursts mediate bidirectional modulation of dopamine signaling by nicotinic receptors
Kramer, P. F., Yanez, A., Clever, F., Zhang, R., Khaliq, Z. M.
10.64898/2025.12.19.695584 — Posted: 2026-02-03
AutoMorphoTrack: A modular framework for quantitative analysis of organelle morphology, motility, and interactions at single-cell resolution
Bayati, A., Schumacher, J. G., Chen, X.
10.1101/2025.07.19.665650 — Posted: 2026-02-02
Machine learning-based image analysis of Parkinson's disease iPS-derived neurons predicts genotype and reveals mitochondria-lysosome abnormalities
Li, Y., Powell, M., Chedid, J., Sutharsan, R., Garrido, A. L., Abu-Bonsrah, D., Pavan, C., Fraser, T., Ovchinnikov, D., Zhong, M., Davis, R., Strbenac, D., Johnston, J. A., Thompson, L. H., Kirik, D., Parish, C. L., Halliday, G. M., Sue, C. M., Dzamko, N., Wali, G.
10.64898/2026.01.28.702423 — Posted: 2026-01-29
Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
Peat, C., Prasad, A., Finkelstein, D. I., Sue, C., Johnston, J., Parish, C., Thompson, L., Kirik, D., Halliday, G.
10.1101/2025.01.09.632283 — Posted: 2026-01-25
Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations
Lee, Y. J., Syed, K., Busquets, O., Li, H., Dunnack, J., Bateup, H., Soldner, F., Hockemeyer, D., Rio, D.
10.1101/2024.02.28.582420 — Posted: 2026-01-22
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
Adami, A., Garza, R., Dorazehi, F., Douse, C. H., Jakobsson, J.
10.1101/2025.10.24.684366 — Posted: 2026-01-22
An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement
Bouabid, S., Vu, M.-A. T., Noggle, C., Vietti-Michelina, S., Brimblecombe, K., Platt, N., Zhang, L., Joshi, A., Cragg, S., Howe, M. W.
10.64898/2026.01.20.700614 — Posted: 2026-01-21
Multi-omics reveal critical differentiation target for Parkinsons' Disease-vulnerable midbrain dopaminergic neurons
Garcia Swinburn, R., Lyu, G., Kreutzmann, J. C., Xiong, A., Kojima, R., Abaurre, C., Tremolanti, C., Gellhaar, S., Uhlen, P., Svenningsson, P., Castelo Branco, G., Dagliyan, O., Salto, C., Arenas, E.
10.1101/2025.06.18.660098 — Posted: 2026-01-20
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
Li, D., Zhang, W., Medina, M., Stuke, J. F. M., Schwarz, A., Brill, J., Brenner, J., Kraus, F., Ohlerich, S., Lizarrondo, J., Pflaum, J., Grass, J. H., Soltow, L.-M., Hammerschmid, D., Weber, N., Welsch, S., Langer, J., Windbergs, M., Harper, W. J., Schuman, E., Hummer, G., Grotjahn, D. A., Wilfling, F.
10.64898/2026.01.17.700056 — Posted: 2026-01-19

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