Channel:  Francis Crick Institute

1,299 Articles

BacPROTACs outperform inhibitors in Mycobacterium tuberculosis
Brown, D. A., Davies, J. J., Fecht, S., Zhang, Y., Kunzelmann, S., Kent, L., Skehel, M., Morreale, F. E.
10.64898/2026.06.12.731830 — Posted: 2026-06-12
Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells
Raguseo, F., Fellows, E., de Chiara, C., Mortishire-Smith, B., Segura-Bayona, S., Cawood, E., Jiang, M., Subtil, F. T., Idilli, A., McCarthy, W., Howell, M., Rittinger, K., MacRae, J. I., Skehel, M., Powell, A., House, D., Bush, J., Boulton, S.
10.64898/2026.06.10.731339 — Posted: 2026-06-11
Minimal essential requirements for neural tube self-organisation
Stuart, H. T., Costantini, E., Wang, J., Krammer, T., Delas, M. J., Melchionda, M., Cornwall-Scoones, J., Schmauss, G., Lendl, T., Ishihara, K., Rand, D., Saez, M., Tanaka, E. M., Briscoe, J.
10.64898/2026.06.06.730555 — Posted: 2026-06-08
Quantitative profiling of JMJD6-catalysed lysine hydroxylation reveals residue-dependent oxygen sensitivity
Kesavan, P., Stuermer, S. M., Räbel, K., Popp, O., Mertins, P., Cockman, M. E., Sugimoto, Y.
10.64898/2026.06.08.730680 — Posted: 2026-06-08
iSBEM: An Open-Source Workflow for Automated ROI Targeting in Volume Electron Microscopy
Ronchi, P., Ross, G., Burrell, A., de Folter, J., Klenz, Y., Darif, N., Young, F., Lawson, M., Albers, J., Pietz, T., Frischknecht, F., Duke, E., Roufosse, C., Collinson, L., Strange, A., Schwab, Y.
10.64898/2026.06.05.730298 — Posted: 2026-06-06
FIKK1, a member of the FIKK kinase family, phosphorylates VAR2CSA and regulates adhesion of Plasmodium falciparum-infected erythrocytes to the placental receptor CSA
Gamain, B., Semblat, J.-P., Eavis, H., Belda, H., Hamelin, R., Paquereau, C.-E., Doerig, C., Treeck, M., Dorin-Semblat, D.
10.64898/2026.03.23.713582 — Posted: 2026-06-05
Topology-aware reconstruction of cellular state landscapes from microscopy using self-supervised learning
Messori, E., Taha, D. M., Fournier, L., Foix Romero, A., Uhlmann, V., Frossard, P., Vincent-Cuaz, C., Patani, R., Luisier, R.
10.64898/2026.05.30.728966 — Posted: 2026-06-03
HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C
Pastore, R., Stanley, J., Kiraly, S., Dubois, C., Monfregola, J., de Luca, A., Guerra, G., Skehel, M., Ballabio, A., Platt, F. M., Eden, E. R.
10.64898/2026.06.01.729255 — Posted: 2026-06-02
GROQ-seq Datasets Across Transcription Factors (LacI, RamR, VanR), T7 RNA Polymerase and TEV Protease
Spinner, A., Sreenivasan, S., McLellan, J. R., Ikonomova, S. P., Cortade, D. L., dOelsnitz, S., Sheldon, K., Vasilyeva, O. B., Alperovich, N. Y., Chadha, A., Nematollahi, L., Dhroso, A., Sisson, Z., Densmore, D., Hudson, C. M., DeBenedictis, E., Kelly, P. J., Reider Apel, A., Ross, D., Baranowski, C.
10.64898/2026.04.15.718744 — Posted: 2026-05-29
High sensitivity imaging of intracellular Cl- reveals the spatiotemporal evolution of GABAergic chloride fluxes in vitro and in vivo
Pasquini, G., Giubbolini, S., Nardi, G., Brondi, M., Beyene, E., Balsi, C., Egidi, A., Tsushima Semini, H., Landi, S., Stancampiano, M., Beale, A. D., Watson, E. M., Edgar, R. S., O'Neill, J. S., Arosio, D., Santi, M., Fassio, A., Lodovichi, C., Ratto, G. M. M.
10.64898/2026.05.27.728254 — Posted: 2026-05-29

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