Channel: Aligning Science Across Parkinson's (ASAP)

480 Articles

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RAB32-linked Parkinson's disease: Deep phenotyping, MDSGene literature review, and application of SynNeurGe criteria

Kleinz, T., Cavallieri, F., Borsche, M., Toschi, G., Valzania, F., Fioravanti, V., Valente, E. M., Mitrotti, P., Avenali, M., Zittel, S., Born, R., Matarazzo, M., Di Fonzo, A., Monfrini, E., Radefeldt, M., Santinelli, L., Griebner, N., Shambetova, C., Brand, M., Gabbert, C., Blauwendraat, C., Trinh, J., Beetz, C., Bauer, P., Brueggemann, N., Global Parkinson's Genetics Program (GP2), , Klein, C.

10.1101/2025.06.03.25328628 — Posted: 2025-06-03

Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout

Goldman, C., Kareva, T., Sarrafha, L., Sahasrabudhe, A., Schuldt, B. R., Ahfeldt, T., Blanchard, J. W.

10.1101/2024.05.21.594886 — Posted: 2025-06-02

Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease

Sah, S., Sauerbeck, A. D., Gupta, J., Perez-Acuna, D., Reiber, J. E., Russell, D., Goralski, T., Henderson, M., Volpicelli-Daley, L. A., Higley, M. J., Kummer, T. T., Biederer, T.

10.1101/2024.06.20.599774 — Posted: 2025-05-31

Kase, D., Zimnik, A. J., Han, Y., Harsch, D. R., Bacha, S., Cox, K. M., Bostan, A. C., Richardson, R. M., Turner, R. S.

10.1101/2024.08.29.610310 — Posted: 2025-05-30

Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease

D'Addario, S. L., Massaro Cenere, M., Cossa, F., Scaricamazza, S., Nesci, V., D'Ottavio, G., Caprioli, D., Ferri, A., Vila, M., Ledonne, A., Mercuri, N. B.

10.1101/2025.04.18.649338 — Posted: 2025-05-27

Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson's disease etiology across diverse ancestral populations

Step, K., Hernandez, C. F., Eltaraifee, E., Hernandez-Medrano, A. J., Kung, P.-J., Ostrozovicova, M., Zirra, A., Perez-Palma, E., Mencacci, N. E., Keller Sarmiento, I. J., Morris, H., Mata, I., Global Parkinson's Genetics Program, , Acosta-Uribe, J., Fang, Z.-H., Bandres Ciga, S.

10.1101/2025.05.21.25328076 — Posted: 2025-05-22

Spatio-molecular analysis of primate subthalamus defines anatomical domains relevant to Parkinson disease and neuropsychiatry

Dumas, S., Francois, C., Karachi, C., Mackenzie, A.

10.1101/2025.05.21.655268 — Posted: 2025-05-21

Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease

Zhang, L., Yasumizu, Y., Deerhake, M. E., Moon, J., Buitrago-Pocasangre, N., Russo, A., Wang, H., Zhu, B., Seibyl, J. P., Reddy, V., Wang, Q., Spillantini, M. G., Posner, D. A., Clatworthy, M., Sumida, T. S., Longbrake, E. E., Cedarbaum, J. M., Hafler, D. A.

10.1101/2025.05.16.654530 — Posted: 2025-05-21

Drug Repurposing for Parkinson's Disease: A Large-Scale Multi-Cohort Study

Hu, Y., Liu, W., Waits, M., Zhao, Y., Olivero-Acosta, M. I., Zhang, L., Scherzer, C. R., Dong, X.

10.1101/2025.05.20.25327943 — Posted: 2025-05-21

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Paz, R. M., Ryan, M. B., Marcott, P. F., Girasole, A. E., Faryean, J., Duong, V., Sridhar, S., Nelson, A. B.

10.1101/2025.05.16.654598 — Posted: 2025-05-21

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