COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

30,479 Articles (22,358 medRxiv, 8,121 bioRxiv)

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Unlocking the Secrets of NSP3: AlphaFold2-assisted Domain Determination in SARS-CoV-2 Protein
Edich, M., Briggs, D., Gao, Y., Thorn, A.
10.1101/2025.01.14.632924 — Posted: 2025-01-15
Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses
Lawrenz, J., Wettstein, L., Rodriguez Alfonso, A., Nchioua, R., von Maltitz, P., Albers, D., Zech, F., Vandeput, J., Stevaert, A., Fois, G., Preising, N., Schmierer, E., Almeida-Hernandez, Y., Petersen, M., Staendker, L., Wiese, S., Braubach, P., Frick, M., Sanchez-Garcia, E., Sauter, D., Kirchhoff, F., Naesens, L., Muench, J.
10.1101/2025.01.14.632953 — Posted: 2025-01-15
Metabolic syndrome enhances SARS-CoV-2 disease severity and reduces mRNA vaccine efficacy in a mouse model
Geeling, E., Stone, E. T., Carpenter, D., Dickson, A., Brien, J., Pinto, A. K.
10.1101/2025.01.15.633120 — Posted: 2025-01-15
A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19
Voloudakis, G., Lee, K. M., Vicari, J., Zhang, W., Hoagland, D., Venkatesh, S., Bian, J., Anyfantakis, M., Wu, Z., Rahman, S., Gao, L., Cho, K., Lee, J. S., Iyengar, S. K., Luoh, S.-W., Assimes, T. L., Hoffman, G., tenOever, B. R., Fullard, J. F., Lynch, J. A., Roussos, P.
10.1101/2025.01.10.25320348 — Posted: 2025-01-14
Metformin on Time to Sustained Recovery in Adults with COVID-19: The ACTIV-6 Randomized Clinical Trial
Bramante, C., Stewart, T. G., Boulware, D., McCarthy, M. W., Gao, Y., Rothman, R. L., Mourad, A., Thicklin, F., Cohen, J., Garcia del Sol, I. T., Ruiz-Unger, J., Shah, N. S., Mehta, M., Quintero Cardona, O., Scott, J., Ginde, A. A., Castro, M., Jayaweera, D., Sulkowski, M., Gentile, N., McTigue, K., Felker, G. M., Collins, S., Dunsmore, S. E., Adam, S. J., Lindsell, C. J., Hernandez, A. F., Naggie, S.
10.1101/2025.01.13.25320485 — Posted: 2025-01-14
Generating cognate epitope sequences of T-cell receptors with a generative transformer
Ma, M., Tu, W., Vasquez-Rios, C., Ding, J.
10.1101/2025.01.13.632824 — Posted: 2025-01-14
Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients
Masuda, K., Iketani, S., Liu, L., Huang, J., Qiao, Y., Shah, J., McNairy, M. L., Groso, C., Ricupero, C., Loffredo, L. F., Wang, Q., Purpura, L., Coelho-dos-Reis, J. G. A., Sheng, Z., Yin, M. T., Tsuji, M.
10.1101/2025.01.12.632164 — Posted: 2025-01-14
MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases
Woods, V., Umansky, T., Russell, S. M., McGovern, B. L., Rosales, R., Rodriguez, M. L., van Bakel, H., Sordillo, E. M., Simon, V., Garcia-Sastre, A., White, K. M., Smith, D. M., Haders, D.
10.1101/2025.01.13.632836 — Posted: 2025-01-14
A Fine-tuned ProtGPT2 (transformer model) for Predicting more Virulent SARS-CoV-2 variants and understanding its virulence by biophysical methods.
Paul D, S., Rebairo J, A., Siddalingappa, R., Venkatachalam, R., Kothandan, G.
10.1101/2025.01.13.632691 — Posted: 2025-01-14
COVID-19 Vaccine Uptake and its Determinants in Cameroon: A Systematic Review and Meta-analysis
Cheuyem, F. Z. L., Amani, A., Achangwa, C., Ajong, B. N., Minkandi, C. A., Zeh, M. M. M. K., Ntsek, L. L. E., Essomba, J. P., Jiogue, R. C., Ndagijimana, O., Nchanji, N. E., Danwang, C.
10.1101/2025.01.12.25320427 — Posted: 2025-01-13

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).